The human papillomavirus (HPV)-related cancer biology: An overview
•Cancer is an important public health problem globally.•HPV is responsible for 30% of all infectious agent-related cancer.•Oncoproteins (E6 and E7) cooperate to promote carcinogenesis.•Oncoproteins can lead to metabolic deregulation and metastasis.•Novel therapeutic and prophylactic vaccines are man...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2018-10, Vol.106, p.1537-1556 |
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| creator | Araldi, Rodrigo Pinheiro Sant’Ana, Thalita Araujo Módolo, Diego Grando de Melo, Thatiana Correa Spadacci-Morena, Diva Denelle de Cassia Stocco, Rita Cerutti, Janete Maria de Souza, Edislane Barreiros |
| description | •Cancer is an important public health problem globally.•HPV is responsible for 30% of all infectious agent-related cancer.•Oncoproteins (E6 and E7) cooperate to promote carcinogenesis.•Oncoproteins can lead to metabolic deregulation and metastasis.•Novel therapeutic and prophylactic vaccines are mandatory.
Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20–25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agent-related cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies. |
| doi_str_mv | 10.1016/j.biopha.2018.06.149 |
| format | Article |
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Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20–25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agent-related cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2018.06.149</identifier><identifier>PMID: 30119229</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animals ; Cancer progression ; Cancer Vaccines - administration & dosage ; Cell Transformation, Viral ; Genotype ; Host-Pathogen Interactions ; HPV ; Humans ; Metastasis ; Mutation ; Neoplasms - metabolism ; Neoplasms - pathology ; Neoplasms - prevention & control ; Neoplasms - virology ; Oncogene Proteins, Viral - metabolism ; Oncology ; Papillomaviridae - genetics ; Papillomaviridae - metabolism ; Papillomaviridae - pathogenicity ; Papillomavirus Infections - metabolism ; Papillomavirus Infections - pathology ; Papillomavirus Infections - prevention & control ; Papillomavirus Infections - virology ; Papillomavirus Vaccines - administration & dosage ; Phenotype ; Prognosis ; Risk Factors</subject><ispartof>Biomedicine & pharmacotherapy, 2018-10, Vol.106, p.1537-1556</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Masson SAS.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-488206ccaf8855eab0dc292468ce78b4c98b1cdcc7bdf8799b6fa44d82605e473</citedby><cites>FETCH-LOGICAL-c408t-488206ccaf8855eab0dc292468ce78b4c98b1cdcc7bdf8799b6fa44d82605e473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0753332218328178$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30119229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Araldi, Rodrigo Pinheiro</creatorcontrib><creatorcontrib>Sant’Ana, Thalita Araujo</creatorcontrib><creatorcontrib>Módolo, Diego Grando</creatorcontrib><creatorcontrib>de Melo, Thatiana Correa</creatorcontrib><creatorcontrib>Spadacci-Morena, Diva Denelle</creatorcontrib><creatorcontrib>de Cassia Stocco, Rita</creatorcontrib><creatorcontrib>Cerutti, Janete Maria</creatorcontrib><creatorcontrib>de Souza, Edislane Barreiros</creatorcontrib><title>The human papillomavirus (HPV)-related cancer biology: An overview</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>•Cancer is an important public health problem globally.•HPV is responsible for 30% of all infectious agent-related cancer.•Oncoproteins (E6 and E7) cooperate to promote carcinogenesis.•Oncoproteins can lead to metabolic deregulation and metastasis.•Novel therapeutic and prophylactic vaccines are mandatory.
Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20–25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agent-related cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies.</description><subject>Animals</subject><subject>Cancer progression</subject><subject>Cancer Vaccines - administration & dosage</subject><subject>Cell Transformation, Viral</subject><subject>Genotype</subject><subject>Host-Pathogen Interactions</subject><subject>HPV</subject><subject>Humans</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - prevention & control</subject><subject>Neoplasms - virology</subject><subject>Oncogene Proteins, Viral - metabolism</subject><subject>Oncology</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - metabolism</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Papillomavirus Infections - metabolism</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - prevention & control</subject><subject>Papillomavirus Infections - virology</subject><subject>Papillomavirus Vaccines - administration & dosage</subject><subject>Phenotype</subject><subject>Prognosis</subject><subject>Risk Factors</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EgvLxDxDKWIaEZ8dxbAakgoAiVYKhsFqO80JdJU2wm6L-e4IKjExvOfdd3UPIOYWEAhVXy6RwbbcwCQMqExAJ5WqPjKjKIBYA-T4ZQZ6lcZoydkSOQ1gCQCZSeUiOUqBUMaZG5Ha-wGjRN2YVdaZzdd02ZuN8H6Lx9OXtMvZYmzWWkTUriz4aKuv2fXsdTVZRu0G_cfh5Sg4qUwc8-7kn5PXhfn43jWfPj093k1lsOch1zKVkIKw1lZRZhqaA0jLFuJAWc1lwq2RBbWltXpSVzJUqRGU4LyUTkCHP0xMy3v3tfPvRY1jrxgWLdW1W2PZBM5BKZoLnckD5DrW-DcFjpTvvGuO3moL-tqeXemdPf9vTIPRgb4hd_DT0RYPlX-hX1wDc7AAcdg7bvQ7W4WCmdB7tWpet-7_hCzvPgcQ</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Araldi, Rodrigo Pinheiro</creator><creator>Sant’Ana, Thalita Araujo</creator><creator>Módolo, Diego Grando</creator><creator>de Melo, Thatiana Correa</creator><creator>Spadacci-Morena, Diva Denelle</creator><creator>de Cassia Stocco, Rita</creator><creator>Cerutti, Janete Maria</creator><creator>de Souza, Edislane Barreiros</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>The human papillomavirus (HPV)-related cancer biology: An overview</title><author>Araldi, Rodrigo Pinheiro ; Sant’Ana, Thalita Araujo ; Módolo, Diego Grando ; de Melo, Thatiana Correa ; Spadacci-Morena, Diva Denelle ; de Cassia Stocco, Rita ; Cerutti, Janete Maria ; de Souza, Edislane Barreiros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-488206ccaf8855eab0dc292468ce78b4c98b1cdcc7bdf8799b6fa44d82605e473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cancer progression</topic><topic>Cancer Vaccines - administration & dosage</topic><topic>Cell Transformation, Viral</topic><topic>Genotype</topic><topic>Host-Pathogen Interactions</topic><topic>HPV</topic><topic>Humans</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - prevention & control</topic><topic>Neoplasms - virology</topic><topic>Oncogene Proteins, Viral - metabolism</topic><topic>Oncology</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomaviridae - metabolism</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Papillomavirus Infections - metabolism</topic><topic>Papillomavirus Infections - pathology</topic><topic>Papillomavirus Infections - prevention & control</topic><topic>Papillomavirus Infections - virology</topic><topic>Papillomavirus Vaccines - administration & dosage</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araldi, Rodrigo Pinheiro</creatorcontrib><creatorcontrib>Sant’Ana, Thalita Araujo</creatorcontrib><creatorcontrib>Módolo, Diego Grando</creatorcontrib><creatorcontrib>de Melo, Thatiana Correa</creatorcontrib><creatorcontrib>Spadacci-Morena, Diva Denelle</creatorcontrib><creatorcontrib>de Cassia Stocco, Rita</creatorcontrib><creatorcontrib>Cerutti, Janete Maria</creatorcontrib><creatorcontrib>de Souza, Edislane Barreiros</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araldi, Rodrigo Pinheiro</au><au>Sant’Ana, Thalita Araujo</au><au>Módolo, Diego Grando</au><au>de Melo, Thatiana Correa</au><au>Spadacci-Morena, Diva Denelle</au><au>de Cassia Stocco, Rita</au><au>Cerutti, Janete Maria</au><au>de Souza, Edislane Barreiros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The human papillomavirus (HPV)-related cancer biology: An overview</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2018-10</date><risdate>2018</risdate><volume>106</volume><spage>1537</spage><epage>1556</epage><pages>1537-1556</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>•Cancer is an important public health problem globally.•HPV is responsible for 30% of all infectious agent-related cancer.•Oncoproteins (E6 and E7) cooperate to promote carcinogenesis.•Oncoproteins can lead to metabolic deregulation and metastasis.•Novel therapeutic and prophylactic vaccines are mandatory.
Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20–25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agent-related cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>30119229</pmid><doi>10.1016/j.biopha.2018.06.149</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cancer progression Cancer Vaccines - administration & dosage Cell Transformation, Viral Genotype Host-Pathogen Interactions HPV Humans Metastasis Mutation Neoplasms - metabolism Neoplasms - pathology Neoplasms - prevention & control Neoplasms - virology Oncogene Proteins, Viral - metabolism Oncology Papillomaviridae - genetics Papillomaviridae - metabolism Papillomaviridae - pathogenicity Papillomavirus Infections - metabolism Papillomavirus Infections - pathology Papillomavirus Infections - prevention & control Papillomavirus Infections - virology Papillomavirus Vaccines - administration & dosage Phenotype Prognosis Risk Factors |
| title | The human papillomavirus (HPV)-related cancer biology: An overview |
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