Adverse effect of paternal hepatitis B virus infection on clinical pregnancy after frozen–thawed embryo transfer
Purpose This study aimed to determine the effect of paternal hepatitis B virus (HBV) infection on reproductive outcomes of couples undergoing frozen–thawed embryo transfer (FET). Methods This retrospective cohort study included FET cycles performed between January 2014 and March 2017 in couples with...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2018-10, Vol.298 (4), p.827-832 |
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| creator | He, Fan Wang, Lisi Zhang, Chanyu Li, Sanglin Sun, Chengguang Hu, Lina |
| description | Purpose
This study aimed to determine the effect of paternal hepatitis B virus (HBV) infection on reproductive outcomes of couples undergoing frozen–thawed embryo transfer (FET).
Methods
This retrospective cohort study included FET cycles performed between January 2014 and March 2017 in couples with a hepatitis B surface antigen (HBsAg)-positive male partner and an HBsAg-negative female partner, which was categorized as HBsAg group. The FET cycles underwent by couples with both HBsAg-negative partners were randomly selected as controls. The primary outcome was clinical pregnancy.
Results
A total of 117 FET cycles, comprising 39 in the HBsAg group and 78 in the control group, were included. Couples with HBsAg-positive male partners had significantly lower clinical pregnancy rate (17.9 vs 41.0%,
P
= 0.013), lower implantation rate (11.1 vs 24.5%,
P
= 0.014), and lower live birth rate (12.8 vs 30.8%,
P
= 0.034) compared with the control group. Moreover, the multivariate logistic regression analysis showed that paternal HBV infection was negatively associated with clinical pregnancy (odds ratio = 0.297, 95% confidence interval 0.108–0.817,
P
= 0.019). The miscarriage rate was not significantly different between the two groups (28.6 vs 25.0%,
P
= 1.000).
Conclusions
Paternal HBV infection resulted in a lower frequency of clinical pregnancy after FET, a difference that was probably attributed to a detrimental effect of HBV on the ability of embryos to survive freezing and thawing. |
| doi_str_mv | 10.1007/s00404-018-4863-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2089853169</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261530854</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-8196e22644e91e08c6415e2b6bfed7719549f0ffb55aeeced01869e398d3e4283</originalsourceid><addsrcrecordid>eNp1kc-KFDEQxoMo7jj6AF4k4GUvrZU_nU6O6-K6woIXPYd0urKbpSc9Jt0r42nfwTf0SUwzq4IgFFRB_epL-D5CXjJ4wwC6twVAgmyA6UZqJRrziGyYFLyBjrHHZANmnUF1J-RZKbcAjGutnpITAYyputyQfDbcYS5IMQT0M50C3bsZc3IjvcE6xjkW-o7exbwUGtMKxSnRWn6MKfrK7TNeJ5f8gbpQT2nI03dMP-9_zDfuGw4Ud30-THTOLpWA-Tl5EtxY8MVD35IvF-8_n182V58-fDw_u2q86PjcaGYUcq6kRMMQtFeStch71Qccuo6ZVpoAIfRt6xA9DtUGZVAYPQiUXIstOT3q7vP0dcEy210sHsfRJZyWYjloo1uxGrElr_9Bb6dl9aBSXLFWgG5lpdiR8nkqJWOw-xx3Lh8sA7sGYo-B2PoTuwZiV-VXD8pLv8Phz8XvBCrAj0Cpq3SN-e_T_1f9BSVel7M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261530854</pqid></control><display><type>article</type><title>Adverse effect of paternal hepatitis B virus infection on clinical pregnancy after frozen–thawed embryo transfer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>He, Fan ; Wang, Lisi ; Zhang, Chanyu ; Li, Sanglin ; Sun, Chengguang ; Hu, Lina</creator><creatorcontrib>He, Fan ; Wang, Lisi ; Zhang, Chanyu ; Li, Sanglin ; Sun, Chengguang ; Hu, Lina</creatorcontrib><description>Purpose
This study aimed to determine the effect of paternal hepatitis B virus (HBV) infection on reproductive outcomes of couples undergoing frozen–thawed embryo transfer (FET).
Methods
This retrospective cohort study included FET cycles performed between January 2014 and March 2017 in couples with a hepatitis B surface antigen (HBsAg)-positive male partner and an HBsAg-negative female partner, which was categorized as HBsAg group. The FET cycles underwent by couples with both HBsAg-negative partners were randomly selected as controls. The primary outcome was clinical pregnancy.
Results
A total of 117 FET cycles, comprising 39 in the HBsAg group and 78 in the control group, were included. Couples with HBsAg-positive male partners had significantly lower clinical pregnancy rate (17.9 vs 41.0%,
P
= 0.013), lower implantation rate (11.1 vs 24.5%,
P
= 0.014), and lower live birth rate (12.8 vs 30.8%,
P
= 0.034) compared with the control group. Moreover, the multivariate logistic regression analysis showed that paternal HBV infection was negatively associated with clinical pregnancy (odds ratio = 0.297, 95% confidence interval 0.108–0.817,
P
= 0.019). The miscarriage rate was not significantly different between the two groups (28.6 vs 25.0%,
P
= 1.000).
Conclusions
Paternal HBV infection resulted in a lower frequency of clinical pregnancy after FET, a difference that was probably attributed to a detrimental effect of HBV on the ability of embryos to survive freezing and thawing.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-018-4863-9</identifier><identifier>PMID: 30116932</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abortion, Spontaneous - epidemiology ; Adult ; Embryo Transfer - methods ; Embryos ; Endocrinology ; Fathers ; Female ; Gynecologic Endocrinology and Reproductive Medicine ; Gynecology ; Health risk assessment ; Hepatitis ; Hepatitis B ; Hepatitis B - complications ; Hepatitis B Surface Antigens - blood ; Human Genetics ; Humans ; Infections ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Pregnancy ; Pregnancy Rate ; Retrospective Studies</subject><ispartof>Archives of gynecology and obstetrics, 2018-10, Vol.298 (4), p.827-832</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8196e22644e91e08c6415e2b6bfed7719549f0ffb55aeeced01869e398d3e4283</citedby><cites>FETCH-LOGICAL-c372t-8196e22644e91e08c6415e2b6bfed7719549f0ffb55aeeced01869e398d3e4283</cites><orcidid>0000-0003-2000-7894</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-018-4863-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-018-4863-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30116932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Fan</creatorcontrib><creatorcontrib>Wang, Lisi</creatorcontrib><creatorcontrib>Zhang, Chanyu</creatorcontrib><creatorcontrib>Li, Sanglin</creatorcontrib><creatorcontrib>Sun, Chengguang</creatorcontrib><creatorcontrib>Hu, Lina</creatorcontrib><title>Adverse effect of paternal hepatitis B virus infection on clinical pregnancy after frozen–thawed embryo transfer</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
This study aimed to determine the effect of paternal hepatitis B virus (HBV) infection on reproductive outcomes of couples undergoing frozen–thawed embryo transfer (FET).
Methods
This retrospective cohort study included FET cycles performed between January 2014 and March 2017 in couples with a hepatitis B surface antigen (HBsAg)-positive male partner and an HBsAg-negative female partner, which was categorized as HBsAg group. The FET cycles underwent by couples with both HBsAg-negative partners were randomly selected as controls. The primary outcome was clinical pregnancy.
Results
A total of 117 FET cycles, comprising 39 in the HBsAg group and 78 in the control group, were included. Couples with HBsAg-positive male partners had significantly lower clinical pregnancy rate (17.9 vs 41.0%,
P
= 0.013), lower implantation rate (11.1 vs 24.5%,
P
= 0.014), and lower live birth rate (12.8 vs 30.8%,
P
= 0.034) compared with the control group. Moreover, the multivariate logistic regression analysis showed that paternal HBV infection was negatively associated with clinical pregnancy (odds ratio = 0.297, 95% confidence interval 0.108–0.817,
P
= 0.019). The miscarriage rate was not significantly different between the two groups (28.6 vs 25.0%,
P
= 1.000).
Conclusions
Paternal HBV infection resulted in a lower frequency of clinical pregnancy after FET, a difference that was probably attributed to a detrimental effect of HBV on the ability of embryos to survive freezing and thawing.</description><subject>Abortion, Spontaneous - epidemiology</subject><subject>Adult</subject><subject>Embryo Transfer - methods</subject><subject>Embryos</subject><subject>Endocrinology</subject><subject>Fathers</subject><subject>Female</subject><subject>Gynecologic Endocrinology and Reproductive Medicine</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infections</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Retrospective Studies</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc-KFDEQxoMo7jj6AF4k4GUvrZU_nU6O6-K6woIXPYd0urKbpSc9Jt0r42nfwTf0SUwzq4IgFFRB_epL-D5CXjJ4wwC6twVAgmyA6UZqJRrziGyYFLyBjrHHZANmnUF1J-RZKbcAjGutnpITAYyputyQfDbcYS5IMQT0M50C3bsZc3IjvcE6xjkW-o7exbwUGtMKxSnRWn6MKfrK7TNeJ5f8gbpQT2nI03dMP-9_zDfuGw4Ud30-THTOLpWA-Tl5EtxY8MVD35IvF-8_n182V58-fDw_u2q86PjcaGYUcq6kRMMQtFeStch71Qccuo6ZVpoAIfRt6xA9DtUGZVAYPQiUXIstOT3q7vP0dcEy210sHsfRJZyWYjloo1uxGrElr_9Bb6dl9aBSXLFWgG5lpdiR8nkqJWOw-xx3Lh8sA7sGYo-B2PoTuwZiV-VXD8pLv8Phz8XvBCrAj0Cpq3SN-e_T_1f9BSVel7M</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>He, Fan</creator><creator>Wang, Lisi</creator><creator>Zhang, Chanyu</creator><creator>Li, Sanglin</creator><creator>Sun, Chengguang</creator><creator>Hu, Lina</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2000-7894</orcidid></search><sort><creationdate>20181001</creationdate><title>Adverse effect of paternal hepatitis B virus infection on clinical pregnancy after frozen–thawed embryo transfer</title><author>He, Fan ; Wang, Lisi ; Zhang, Chanyu ; Li, Sanglin ; Sun, Chengguang ; Hu, Lina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8196e22644e91e08c6415e2b6bfed7719549f0ffb55aeeced01869e398d3e4283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abortion, Spontaneous - epidemiology</topic><topic>Adult</topic><topic>Embryo Transfer - methods</topic><topic>Embryos</topic><topic>Endocrinology</topic><topic>Fathers</topic><topic>Female</topic><topic>Gynecologic Endocrinology and Reproductive Medicine</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infections</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Fan</creatorcontrib><creatorcontrib>Wang, Lisi</creatorcontrib><creatorcontrib>Zhang, Chanyu</creatorcontrib><creatorcontrib>Li, Sanglin</creatorcontrib><creatorcontrib>Sun, Chengguang</creatorcontrib><creatorcontrib>Hu, Lina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Fan</au><au>Wang, Lisi</au><au>Zhang, Chanyu</au><au>Li, Sanglin</au><au>Sun, Chengguang</au><au>Hu, Lina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse effect of paternal hepatitis B virus infection on clinical pregnancy after frozen–thawed embryo transfer</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>298</volume><issue>4</issue><spage>827</spage><epage>832</epage><pages>827-832</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
This study aimed to determine the effect of paternal hepatitis B virus (HBV) infection on reproductive outcomes of couples undergoing frozen–thawed embryo transfer (FET).
Methods
This retrospective cohort study included FET cycles performed between January 2014 and March 2017 in couples with a hepatitis B surface antigen (HBsAg)-positive male partner and an HBsAg-negative female partner, which was categorized as HBsAg group. The FET cycles underwent by couples with both HBsAg-negative partners were randomly selected as controls. The primary outcome was clinical pregnancy.
Results
A total of 117 FET cycles, comprising 39 in the HBsAg group and 78 in the control group, were included. Couples with HBsAg-positive male partners had significantly lower clinical pregnancy rate (17.9 vs 41.0%,
P
= 0.013), lower implantation rate (11.1 vs 24.5%,
P
= 0.014), and lower live birth rate (12.8 vs 30.8%,
P
= 0.034) compared with the control group. Moreover, the multivariate logistic regression analysis showed that paternal HBV infection was negatively associated with clinical pregnancy (odds ratio = 0.297, 95% confidence interval 0.108–0.817,
P
= 0.019). The miscarriage rate was not significantly different between the two groups (28.6 vs 25.0%,
P
= 1.000).
Conclusions
Paternal HBV infection resulted in a lower frequency of clinical pregnancy after FET, a difference that was probably attributed to a detrimental effect of HBV on the ability of embryos to survive freezing and thawing.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30116932</pmid><doi>10.1007/s00404-018-4863-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2000-7894</orcidid></addata></record> |
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| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2018-10, Vol.298 (4), p.827-832 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abortion, Spontaneous - epidemiology Adult Embryo Transfer - methods Embryos Endocrinology Fathers Female Gynecologic Endocrinology and Reproductive Medicine Gynecology Health risk assessment Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B Surface Antigens - blood Human Genetics Humans Infections Logistic Models Male Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Pregnancy Pregnancy Rate Retrospective Studies |
| title | Adverse effect of paternal hepatitis B virus infection on clinical pregnancy after frozen–thawed embryo transfer |
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