Fasciculation intensity and disease progression in amyotrophic lateral sclerosis
•Fasciculation intensity in patients with amyotrophic lateral sclerosis (ALS) was measured using neuromuscular ultrasound.•Fasciculation frequency appears linked to disease progression.•Assessment of fasciculations is a noninvasive approach that may provide insight into ALS disease pathophysiology....
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| Veröffentlicht in: | Clinical neurophysiology 2018-10, Vol.129 (10), p.2149-2154 |
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| creator | Tsugawa, Jun Dharmadasa, Thanuja Ma, Yan Huynh, William Vucic, Steve Kiernan, Matthew C. |
| description | •Fasciculation intensity in patients with amyotrophic lateral sclerosis (ALS) was measured using neuromuscular ultrasound.•Fasciculation frequency appears linked to disease progression.•Assessment of fasciculations is a noninvasive approach that may provide insight into ALS disease pathophysiology.
To investigate the association between the frequency and intensity of fasciculations with clinical measures of disease progression in amyotrophic lateral sclerosis (ALS).
Twenty-four consecutive patients with ALS underwent clinical review and neuromuscular ultrasound assessment to detect intensity of fasciculations. Results were correlated with clinical markers of disease severity, as measured by the ALS Functional Rating Scale-revised (ALSFRS-R) and rate of disease progression (ΔFS), in addition to assessment of cortical motor function.
Disease duration negatively correlated (R = −0.530, p |
| doi_str_mv | 10.1016/j.clinph.2018.07.015 |
| format | Article |
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To investigate the association between the frequency and intensity of fasciculations with clinical measures of disease progression in amyotrophic lateral sclerosis (ALS).
Twenty-four consecutive patients with ALS underwent clinical review and neuromuscular ultrasound assessment to detect intensity of fasciculations. Results were correlated with clinical markers of disease severity, as measured by the ALS Functional Rating Scale-revised (ALSFRS-R) and rate of disease progression (ΔFS), in addition to assessment of cortical motor function.
Disease duration negatively correlated (R = −0.530, p < 0.01) with fasciculation intensity, while the ΔFS positively correlated with the fasciculation number (R = 0.626, p < 0.01). In terms of potential central contributions to ectopic impulse generation, patients were classified into cohorts based on their fasciculation intensity and short interval intracortical inhibition (SICI). ΔFS was significantly higher in patients with established hyperexcitability (low SICI) with high fasciculation intensity compared to those patients with minimal SICI change.
Fasciculation intensity appears linked to disease progression and separately to markers of cortical dysfunction, specifically the advent of cortical hyperexcitability.
Assessment of the intensity of patient fasciculations is a noninvasive approach that may provide further insight disease pathophysiology in ALS.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2018.07.015</identifier><identifier>PMID: 30114663</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amyotrophic lateral sclerosis ; Disease progression rate ; Fasciculation ; Neuromuscular ultrasound ; Short interval intracortical inhibition</subject><ispartof>Clinical neurophysiology, 2018-10, Vol.129 (10), p.2149-2154</ispartof><rights>2018 International Federation of Clinical Neurophysiology</rights><rights>Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-c3bbbce0921b7e57c492a8f597001aae2f1e7d69ddc176e53ea957093ca3a4ec3</citedby><cites>FETCH-LOGICAL-c428t-c3bbbce0921b7e57c492a8f597001aae2f1e7d69ddc176e53ea957093ca3a4ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1388245718311763$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30114663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsugawa, Jun</creatorcontrib><creatorcontrib>Dharmadasa, Thanuja</creatorcontrib><creatorcontrib>Ma, Yan</creatorcontrib><creatorcontrib>Huynh, William</creatorcontrib><creatorcontrib>Vucic, Steve</creatorcontrib><creatorcontrib>Kiernan, Matthew C.</creatorcontrib><title>Fasciculation intensity and disease progression in amyotrophic lateral sclerosis</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>•Fasciculation intensity in patients with amyotrophic lateral sclerosis (ALS) was measured using neuromuscular ultrasound.•Fasciculation frequency appears linked to disease progression.•Assessment of fasciculations is a noninvasive approach that may provide insight into ALS disease pathophysiology.
To investigate the association between the frequency and intensity of fasciculations with clinical measures of disease progression in amyotrophic lateral sclerosis (ALS).
Twenty-four consecutive patients with ALS underwent clinical review and neuromuscular ultrasound assessment to detect intensity of fasciculations. Results were correlated with clinical markers of disease severity, as measured by the ALS Functional Rating Scale-revised (ALSFRS-R) and rate of disease progression (ΔFS), in addition to assessment of cortical motor function.
Disease duration negatively correlated (R = −0.530, p < 0.01) with fasciculation intensity, while the ΔFS positively correlated with the fasciculation number (R = 0.626, p < 0.01). In terms of potential central contributions to ectopic impulse generation, patients were classified into cohorts based on their fasciculation intensity and short interval intracortical inhibition (SICI). ΔFS was significantly higher in patients with established hyperexcitability (low SICI) with high fasciculation intensity compared to those patients with minimal SICI change.
Fasciculation intensity appears linked to disease progression and separately to markers of cortical dysfunction, specifically the advent of cortical hyperexcitability.
Assessment of the intensity of patient fasciculations is a noninvasive approach that may provide further insight disease pathophysiology in ALS.</description><subject>Amyotrophic lateral sclerosis</subject><subject>Disease progression rate</subject><subject>Fasciculation</subject><subject>Neuromuscular ultrasound</subject><subject>Short interval intracortical inhibition</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwBwhlySZh7Dxsb5BQRQGpEixgbTnOhLrKo9gJUv8eVyksWc0szp3HIeSaQkKBFnfbxDS2220SBlQkwBOg-QmZU8FZLGTOTkOfChGzLOczcuH9FgA4ZOyczFKgNCuKdE7eVtoba8ZGD7bvItsN2Hk77CPdVVFlPWqP0c71nw69n4hIt_t-cP1uY00Ucuh0E3nToOu99ZfkrNaNx6tjXZCP1eP78jlevz69LB_WscmYGGKTlmVpECSjJcecm0wyLepccgCqNbKaIq8KWVWG8gLzFLXMOcjU6FRnaNIFuZ3mhuO-RvSDaq032DS6w370ioGQIpNFAQHNJtSEC73DWu2cbbXbKwrq4FJt1eRSHVwq4Cq4DLGb44axbLH6C_3KC8D9BGD489uiU0EldgYr69AMqurt_xt-AJpiiTw</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Tsugawa, Jun</creator><creator>Dharmadasa, Thanuja</creator><creator>Ma, Yan</creator><creator>Huynh, William</creator><creator>Vucic, Steve</creator><creator>Kiernan, Matthew C.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Fasciculation intensity and disease progression in amyotrophic lateral sclerosis</title><author>Tsugawa, Jun ; Dharmadasa, Thanuja ; Ma, Yan ; Huynh, William ; Vucic, Steve ; Kiernan, Matthew C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-c3bbbce0921b7e57c492a8f597001aae2f1e7d69ddc176e53ea957093ca3a4ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amyotrophic lateral sclerosis</topic><topic>Disease progression rate</topic><topic>Fasciculation</topic><topic>Neuromuscular ultrasound</topic><topic>Short interval intracortical inhibition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsugawa, Jun</creatorcontrib><creatorcontrib>Dharmadasa, Thanuja</creatorcontrib><creatorcontrib>Ma, Yan</creatorcontrib><creatorcontrib>Huynh, William</creatorcontrib><creatorcontrib>Vucic, Steve</creatorcontrib><creatorcontrib>Kiernan, Matthew C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsugawa, Jun</au><au>Dharmadasa, Thanuja</au><au>Ma, Yan</au><au>Huynh, William</au><au>Vucic, Steve</au><au>Kiernan, Matthew C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fasciculation intensity and disease progression in amyotrophic lateral sclerosis</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2018-10</date><risdate>2018</risdate><volume>129</volume><issue>10</issue><spage>2149</spage><epage>2154</epage><pages>2149-2154</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>•Fasciculation intensity in patients with amyotrophic lateral sclerosis (ALS) was measured using neuromuscular ultrasound.•Fasciculation frequency appears linked to disease progression.•Assessment of fasciculations is a noninvasive approach that may provide insight into ALS disease pathophysiology.
To investigate the association between the frequency and intensity of fasciculations with clinical measures of disease progression in amyotrophic lateral sclerosis (ALS).
Twenty-four consecutive patients with ALS underwent clinical review and neuromuscular ultrasound assessment to detect intensity of fasciculations. Results were correlated with clinical markers of disease severity, as measured by the ALS Functional Rating Scale-revised (ALSFRS-R) and rate of disease progression (ΔFS), in addition to assessment of cortical motor function.
Disease duration negatively correlated (R = −0.530, p < 0.01) with fasciculation intensity, while the ΔFS positively correlated with the fasciculation number (R = 0.626, p < 0.01). In terms of potential central contributions to ectopic impulse generation, patients were classified into cohorts based on their fasciculation intensity and short interval intracortical inhibition (SICI). ΔFS was significantly higher in patients with established hyperexcitability (low SICI) with high fasciculation intensity compared to those patients with minimal SICI change.
Fasciculation intensity appears linked to disease progression and separately to markers of cortical dysfunction, specifically the advent of cortical hyperexcitability.
Assessment of the intensity of patient fasciculations is a noninvasive approach that may provide further insight disease pathophysiology in ALS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30114663</pmid><doi>10.1016/j.clinph.2018.07.015</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Amyotrophic lateral sclerosis Disease progression rate Fasciculation Neuromuscular ultrasound Short interval intracortical inhibition |
| title | Fasciculation intensity and disease progression in amyotrophic lateral sclerosis |
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