Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP

LATS (large tumor suppressor) or warts is a Ser/Thr kinase that belongs to the Ndr/LATS subfamily of AGC (protein kinase A/PKG/PKC) kinases. It is a tumor suppressor gene originally isolated from Drosophila and recently isolated from mice and humans. Drosophila or mice mutant for LATS develop tumors...

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Veröffentlicht in:	The Journal of biological chemistry 2008-02, Vol.283 (9), p.5496-5509
Hauptverfasser:	Hao, Yawei, Chun, Alex, Cheung, Kevin, Rashidi, Babak, Yang, Xiaolong
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Motifs - genetics Animals Cell Cycle Proteins Cell Nucleus - genetics Cell Nucleus - metabolism Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Drosophila Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic - genetics HeLa Cells Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Nuclear Proteins - genetics Nuclear Proteins - metabolism Oligonucleotide Array Sequence Analysis Oncogene Proteins - genetics Oncogene Proteins - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - genetics Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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