Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents
The purpose of this study was to evaluate the effects of the antileishmanials meglumine antimoniate and pentamidine against Sporothrix schenckii complex. The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifung...
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| Veröffentlicht in: | Future microbiology 2018-08, Vol.13 (10), p.1129-1140 |
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| creator | Brilhante, Raimunda Sn Pereira, Vandbergue S Oliveira, Jonathas S Lopes, Raissa Gp Rodrigues, Anderson M Camargo, Zoilo P Pereira-Neto, Waldemiro A Castelo-Branco, Débora Scm Cordeiro, Rossana A Sidrim, José Jc Rocha, Marcos Fg |
| description | The purpose of this study was to evaluate the effects of the antileishmanials meglumine antimoniate and pentamidine against Sporothrix schenckii complex.
The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifungal drugs (amphotericin B, itraconazole and terbinafine) was evaluated by the checkerboard assay. The effect of prior exposure of Sporothrix spp. yeast cells to antileishmanials was evaluated by broth microdilution.
Only pentamidine showed antifungal activity against Sporothrix spp. Synergistic interactions were observed between pentamidine and the antifungals. Also, the pre-exposure to meglumine antimoniate reduced the susceptibility of Sardinella brasiliensis and S. schenckii sensu stricto to amphotericin B and itraconazole.
Pentamidine showed antifungal activity against Sporothrix spp., indicating it is a possible therapeutic alternative for the treatment of sporotrichosis. |
| doi_str_mv | 10.2217/fmb-2018-0070 |
| format | Article |
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The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifungal drugs (amphotericin B, itraconazole and terbinafine) was evaluated by the checkerboard assay. The effect of prior exposure of Sporothrix spp. yeast cells to antileishmanials was evaluated by broth microdilution.
Only pentamidine showed antifungal activity against Sporothrix spp. Synergistic interactions were observed between pentamidine and the antifungals. Also, the pre-exposure to meglumine antimoniate reduced the susceptibility of Sardinella brasiliensis and S. schenckii sensu stricto to amphotericin B and itraconazole.
Pentamidine showed antifungal activity against Sporothrix spp., indicating it is a possible therapeutic alternative for the treatment of sporotrichosis.</description><identifier>ISSN: 1746-0913</identifier><identifier>EISSN: 1746-0921</identifier><identifier>DOI: 10.2217/fmb-2018-0070</identifier><identifier>PMID: 30113216</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Amphotericin B ; Antifungal activity ; Antifungal agents ; Antifungal Agents - pharmacology ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Drug Synergism ; Drugs ; Exposure ; Itraconazole ; Meglumine antimoniate ; Metabolism ; Microbial Sensitivity Tests ; Microbial Viability - drug effects ; Microscopy ; Morphology ; Parasitic diseases ; Pentamidine ; Pentamidine - pharmacology ; Sporothrix ; Sporothrix - classification ; Sporothrix - drug effects ; Sporothrix - physiology ; Sporothrix schenckii ; Sporotrichosis ; Synergism ; Terbinafine ; Variance analysis ; Yeasts</subject><ispartof>Future microbiology, 2018-08, Vol.13 (10), p.1129-1140</ispartof><rights>Copyright Future Medicine Ltd Aug 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-9a094d5dbecdac4ef234f9812ce447a10364915576a453bf57ed771e725c85283</citedby><cites>FETCH-LOGICAL-c321t-9a094d5dbecdac4ef234f9812ce447a10364915576a453bf57ed771e725c85283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30113216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brilhante, Raimunda Sn</creatorcontrib><creatorcontrib>Pereira, Vandbergue S</creatorcontrib><creatorcontrib>Oliveira, Jonathas S</creatorcontrib><creatorcontrib>Lopes, Raissa Gp</creatorcontrib><creatorcontrib>Rodrigues, Anderson M</creatorcontrib><creatorcontrib>Camargo, Zoilo P</creatorcontrib><creatorcontrib>Pereira-Neto, Waldemiro A</creatorcontrib><creatorcontrib>Castelo-Branco, Débora Scm</creatorcontrib><creatorcontrib>Cordeiro, Rossana A</creatorcontrib><creatorcontrib>Sidrim, José Jc</creatorcontrib><creatorcontrib>Rocha, Marcos Fg</creatorcontrib><title>Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents</title><title>Future microbiology</title><addtitle>Future Microbiol</addtitle><description>The purpose of this study was to evaluate the effects of the antileishmanials meglumine antimoniate and pentamidine against Sporothrix schenckii complex.
The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifungal drugs (amphotericin B, itraconazole and terbinafine) was evaluated by the checkerboard assay. The effect of prior exposure of Sporothrix spp. yeast cells to antileishmanials was evaluated by broth microdilution.
Only pentamidine showed antifungal activity against Sporothrix spp. Synergistic interactions were observed between pentamidine and the antifungals. Also, the pre-exposure to meglumine antimoniate reduced the susceptibility of Sardinella brasiliensis and S. schenckii sensu stricto to amphotericin B and itraconazole.
Pentamidine showed antifungal activity against Sporothrix spp., indicating it is a possible therapeutic alternative for the treatment of sporotrichosis.</description><subject>Amphotericin B</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Drug Synergism</subject><subject>Drugs</subject><subject>Exposure</subject><subject>Itraconazole</subject><subject>Meglumine antimoniate</subject><subject>Metabolism</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbial Viability - drug effects</subject><subject>Microscopy</subject><subject>Morphology</subject><subject>Parasitic diseases</subject><subject>Pentamidine</subject><subject>Pentamidine - pharmacology</subject><subject>Sporothrix</subject><subject>Sporothrix - classification</subject><subject>Sporothrix - drug effects</subject><subject>Sporothrix - physiology</subject><subject>Sporothrix schenckii</subject><subject>Sporotrichosis</subject><subject>Synergism</subject><subject>Terbinafine</subject><subject>Variance analysis</subject><subject>Yeasts</subject><issn>1746-0913</issn><issn>1746-0921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkb1P5DAQxS3EiY-FkhZZoqEJ57HjOCkR4ktCupPurrYcZ7LxktiLnWiX__6yYqGgmil-783TPEIugN1wDupnO9QZZ1BmjCl2QE5A5UXGKg6HXzuIY3Ka0ooxWUIFR-RYMADBoTghw2_0oxlc4zxS5ztXuzHRsUO6jGEzdjS09M86xDB20W1psh16--octWFY97ilxjcUt3tdevcYly4NdONmrfGjaye_ND01y_lOOiM_WtMnPN_PBfn3cP_37il7-fX4fHf7ktk51ZhVhlV5I5sabWNsji0XeVuVwC3muTLARJFXIKUqTC5F3UqFjVKAiktbSl6KBbn-8F3H8DZhGvXgksW-Nx7DlDRnZcVLBYWc0atv6CpM0c_pNBe8nO0k7AyzD8rGkFLEVq-jG0x818D0rgc996B3PehdDzN_uXed6gGbL_rz8eI_DOWEXA</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Brilhante, Raimunda Sn</creator><creator>Pereira, Vandbergue S</creator><creator>Oliveira, Jonathas S</creator><creator>Lopes, Raissa Gp</creator><creator>Rodrigues, Anderson M</creator><creator>Camargo, Zoilo P</creator><creator>Pereira-Neto, Waldemiro A</creator><creator>Castelo-Branco, Débora Scm</creator><creator>Cordeiro, Rossana A</creator><creator>Sidrim, José Jc</creator><creator>Rocha, Marcos Fg</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201808</creationdate><title>Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents</title><author>Brilhante, Raimunda Sn ; Pereira, Vandbergue S ; Oliveira, Jonathas S ; Lopes, Raissa Gp ; Rodrigues, Anderson M ; Camargo, Zoilo P ; Pereira-Neto, Waldemiro A ; Castelo-Branco, Débora Scm ; Cordeiro, Rossana A ; Sidrim, José Jc ; Rocha, Marcos Fg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-9a094d5dbecdac4ef234f9812ce447a10364915576a453bf57ed771e725c85283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amphotericin B</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - 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Academic</collection><jtitle>Future microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brilhante, Raimunda Sn</au><au>Pereira, Vandbergue S</au><au>Oliveira, Jonathas S</au><au>Lopes, Raissa Gp</au><au>Rodrigues, Anderson M</au><au>Camargo, Zoilo P</au><au>Pereira-Neto, Waldemiro A</au><au>Castelo-Branco, Débora Scm</au><au>Cordeiro, Rossana A</au><au>Sidrim, José Jc</au><au>Rocha, Marcos Fg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents</atitle><jtitle>Future microbiology</jtitle><addtitle>Future Microbiol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>13</volume><issue>10</issue><spage>1129</spage><epage>1140</epage><pages>1129-1140</pages><issn>1746-0913</issn><eissn>1746-0921</eissn><abstract>The purpose of this study was to evaluate the effects of the antileishmanials meglumine antimoniate and pentamidine against Sporothrix schenckii complex.
The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifungal drugs (amphotericin B, itraconazole and terbinafine) was evaluated by the checkerboard assay. The effect of prior exposure of Sporothrix spp. yeast cells to antileishmanials was evaluated by broth microdilution.
Only pentamidine showed antifungal activity against Sporothrix spp. Synergistic interactions were observed between pentamidine and the antifungals. Also, the pre-exposure to meglumine antimoniate reduced the susceptibility of Sardinella brasiliensis and S. schenckii sensu stricto to amphotericin B and itraconazole.
Pentamidine showed antifungal activity against Sporothrix spp., indicating it is a possible therapeutic alternative for the treatment of sporotrichosis.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>30113216</pmid><doi>10.2217/fmb-2018-0070</doi><tpages>12</tpages></addata></record> |
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| ispartof | Future microbiology, 2018-08, Vol.13 (10), p.1129-1140 |
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| subjects | Amphotericin B Antifungal activity Antifungal agents Antifungal Agents - pharmacology Biofilms Biofilms - drug effects Biofilms - growth & development Drug Synergism Drugs Exposure Itraconazole Meglumine antimoniate Metabolism Microbial Sensitivity Tests Microbial Viability - drug effects Microscopy Morphology Parasitic diseases Pentamidine Pentamidine - pharmacology Sporothrix Sporothrix - classification Sporothrix - drug effects Sporothrix - physiology Sporothrix schenckii Sporotrichosis Synergism Terbinafine Variance analysis Yeasts |
| title | Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents |
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