Anti-HIV-1 Activity of Poly(mandelic acid) Derivatives
Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water- soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were...
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| Veröffentlicht in: | Biomacromolecules 2007-01, Vol.8 (11), p.3308-3316 |
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| container_title | Biomacromolecules |
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| creator | Ward, Marty Yu, Bing Wyatt, Victor Griffith, Jelani Craft, Tara Neurath, ARobert Strick, Nathan Li, Yun-Yao Wertz, David L Pojman, John A Lowe, Andrew B |
| description | Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water- soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H sub(2)SO sub(4), which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H sub(2)SO sub(4)-prepared PMDA. |
| doi_str_mv | 10.1021/bm070221yPII:S1525-7797(07)00221-8 |
| format | Article |
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| issn | 1525-7797 1526-4602 |
| language | eng |
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| source | American Chemical Society Journals |
| subjects | Human immunodeficiency virus 1 |
| title | Anti-HIV-1 Activity of Poly(mandelic acid) Derivatives |
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