Cocaine increases intracellular calcium and reactive oxygen species, depolarizes mitochondria, and activates genes associated with heart failure and remodeling

To determine the cardiovascular molecular events associated with acute exposure to cocaine, the present study utilized in vivo analysis of left-ventricular heart function in adult rabbits, fluorescence confocal microscopy of fluo-2, rhod-2, (5-(and-6) carboxy 2',7' dichlorodihydrofluores-c...

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Veröffentlicht in:	Cardiovascular toxicology 2005-01, Vol.5 (4), p.377-390
Hauptverfasser:	Lattanzio, Jr, Frank A, Tiangco, David, Osgood, Christopher, Beebe, Stephen, Kerry, Julie, Hargrave, Barbara Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Calcium - metabolism Calcium Channel Blockers - pharmacology Cells Cocaine Cocaine - toxicity Dose-Response Relationship, Drug Female Gene expression Gene Expression Regulation - drug effects Glutathione - pharmacology Heart failure Heart Failure - genetics Intracellular Membranes - drug effects Intracellular Membranes - physiology Membrane Potentials - drug effects Membrane Potentials - physiology Microscopy, Confocal Mitochondria - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Narcotics - toxicity Oligonucleotide Array Sequence Analysis Rabbits Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Transcriptional Activation Ventricular Function, Left - drug effects Ventricular Function, Left - genetics Ventricular Remodeling - genetics
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