The role of cathepsin B in autophagy during obesity: A systematic review
White adipose tissue (WAT) regulates energy homeostasis by releasing adipokines and modulating cell maintenance. Nutrient excess affects adipocyte hypertrophy directly in WAT by increasing excessively the activity of autophagy systems, generating proinflammatory markers and increasing infiltration o...
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| Veröffentlicht in: | Life sciences (1973) 2018-09, Vol.209, p.274-281 |
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| container_title | Life sciences (1973) |
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| creator | Araujo, Thaís F. Cordeiro, André V. Vasconcelos, Diogo A.A. Vitzel, Kaio F. Silva, Vagner R.R. |
| description | White adipose tissue (WAT) regulates energy homeostasis by releasing adipokines and modulating cell maintenance. Nutrient excess affects adipocyte hypertrophy directly in WAT by increasing excessively the activity of autophagy systems, generating proinflammatory markers and increasing infiltration of macrophages, causing metabolic diseases such as obesity and diabetes. Evidences suggest that cathepsin B (CTSB), a papain-like cysteine peptidase protein, can modulate autophagy processes in adipocytes. This review will focus on the role of CTSB in autophagy under conditions of obesity.
During obese conditions, white adipose tissue (WAT) accumulation causes adipocyte hypertrophy and cathepsin B (CTSB) release, which leads to an excessive increase of autophagy in adipocytes and enhancing of inflammation and macrophage infiltration, therefore contributing to metabolic syndrome. [Display omitted]
•Cathepsin B (CTSB) modulates autophagy process in adipocytes.•CTSB expression increases during obesity conditions.•CTSB expression modulates inflammatory markers under conditions of obesity. |
| doi_str_mv | 10.1016/j.lfs.2018.08.024 |
| format | Article |
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During obese conditions, white adipose tissue (WAT) accumulation causes adipocyte hypertrophy and cathepsin B (CTSB) release, which leads to an excessive increase of autophagy in adipocytes and enhancing of inflammation and macrophage infiltration, therefore contributing to metabolic syndrome. [Display omitted]
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During obese conditions, white adipose tissue (WAT) accumulation causes adipocyte hypertrophy and cathepsin B (CTSB) release, which leads to an excessive increase of autophagy in adipocytes and enhancing of inflammation and macrophage infiltration, therefore contributing to metabolic syndrome. [Display omitted]
•Cathepsin B (CTSB) modulates autophagy process in adipocytes.•CTSB expression increases during obesity conditions.•CTSB expression modulates inflammatory markers under conditions of obesity.</description><subject>Adipocytes</subject><subject>Adipose tissue</subject><subject>Adipose tissues</subject><subject>Autophagy</subject><subject>Cathepsin B</subject><subject>Cells</subject><subject>Diabetes mellitus</subject><subject>Energy balance</subject><subject>Homeostasis</subject><subject>Hypertrophy</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Macrophages</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Papain</subject><subject>Peptidase</subject><subject>Phagocytosis</subject><subject>Proteins</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo7vrxA7xIwIuXrpM2bVI9rYtfIHjRc0jT6W6WbrMmrbL_3iyrHjwIwwwMz7wMDyFnDCYMWHG1nLRNmKTA5ARipXyPjJkUZQJFxvbJGOIqyVLIR-QohCUA5LnIDskoAwaCFXJMHl8XSL1rkbqGGt0vcB1sR29pbHro3Xqh5xtaD952c-oqDLbfXNMpDZvQ40r31lCPHxY_T8hBo9uAp9_zmLzd373OHpPnl4en2fQ5MRxEnxTMAC95hiVjVS4brEX8H3WZF1ygxqpEA6UuasF4nadaVE2DFRcyrzgg1Nkxudzlrr17HzD0amWDwbbVHbohqBSkFHkmCojoxR906Qbfxe9UypjMZFoKHim2o4x3IXhs1NrblfYbxUBtNauliprVVrOCWOn25vw7eahWWP9e_HiNwM0OwKgi6vEqGIudwdp6NL2qnf0n_gtgAIwW</recordid><startdate>20180915</startdate><enddate>20180915</enddate><creator>Araujo, Thaís F.</creator><creator>Cordeiro, André V.</creator><creator>Vasconcelos, Diogo A.A.</creator><creator>Vitzel, Kaio F.</creator><creator>Silva, Vagner R.R.</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4793-1075</orcidid></search><sort><creationdate>20180915</creationdate><title>The role of cathepsin B in autophagy during obesity: A systematic review</title><author>Araujo, Thaís F. ; Cordeiro, André V. ; Vasconcelos, Diogo A.A. ; Vitzel, Kaio F. ; Silva, Vagner R.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-61c04943e911b58fed7201ea95647eaeb9ec09a6d714d52a7bffeb4785b40e0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipocytes</topic><topic>Adipose tissue</topic><topic>Adipose tissues</topic><topic>Autophagy</topic><topic>Cathepsin B</topic><topic>Cells</topic><topic>Diabetes mellitus</topic><topic>Energy balance</topic><topic>Homeostasis</topic><topic>Hypertrophy</topic><topic>Infiltration</topic><topic>Inflammation</topic><topic>Macrophages</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Papain</topic><topic>Peptidase</topic><topic>Phagocytosis</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araujo, Thaís F.</creatorcontrib><creatorcontrib>Cordeiro, André V.</creatorcontrib><creatorcontrib>Vasconcelos, Diogo A.A.</creatorcontrib><creatorcontrib>Vitzel, Kaio F.</creatorcontrib><creatorcontrib>Silva, Vagner R.R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araujo, Thaís F.</au><au>Cordeiro, André V.</au><au>Vasconcelos, Diogo A.A.</au><au>Vitzel, Kaio F.</au><au>Silva, Vagner R.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of cathepsin B in autophagy during obesity: A systematic review</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2018-09-15</date><risdate>2018</risdate><volume>209</volume><spage>274</spage><epage>281</epage><pages>274-281</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>White adipose tissue (WAT) regulates energy homeostasis by releasing adipokines and modulating cell maintenance. Nutrient excess affects adipocyte hypertrophy directly in WAT by increasing excessively the activity of autophagy systems, generating proinflammatory markers and increasing infiltration of macrophages, causing metabolic diseases such as obesity and diabetes. Evidences suggest that cathepsin B (CTSB), a papain-like cysteine peptidase protein, can modulate autophagy processes in adipocytes. This review will focus on the role of CTSB in autophagy under conditions of obesity.
During obese conditions, white adipose tissue (WAT) accumulation causes adipocyte hypertrophy and cathepsin B (CTSB) release, which leads to an excessive increase of autophagy in adipocytes and enhancing of inflammation and macrophage infiltration, therefore contributing to metabolic syndrome. [Display omitted]
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Adipocytes Adipose tissue Adipose tissues Autophagy Cathepsin B Cells Diabetes mellitus Energy balance Homeostasis Hypertrophy Infiltration Inflammation Macrophages Metabolic disorders Obesity Papain Peptidase Phagocytosis Proteins |
| title | The role of cathepsin B in autophagy during obesity: A systematic review |
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