Delayed spironolactone administration prevents the transition from acute kidney injury to chronic kidney disease through improving renal inflammation

Acute kidney injury (AKI) is not as harmless as previously thought since it may lead to chronic kidney disease (CKD). Because most of the time ischemic AKI occurs unexpectedly, it is difficult to prevent its occurrence and there are no specific therapeutic approaches to prevent the AKI to CKD transi...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2019-05, Vol.34 (5), p.794-801
Hauptverfasser:	Barrera-Chimal, Jonatan, Rocha, Leslie, Amador-Martínez, Isabel, Pérez-Villalva, Rosalba, González, Rafael, Cortés-González, Cesar, Uribe, Norma, Ramírez, Victoria, Berman, Nathan, Gamba, Gerardo, Bobadilla, Norma A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Delayed-Action Preparations Disease Models, Animal Disease Progression Inflammation - metabolism Inflammation - pathology Kidney - metabolism Kidney - pathology Male Mineralocorticoid Receptor Antagonists - administration & dosage Rats Rats, Wistar Receptor, Endothelin B - metabolism Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Renal Insufficiency, Chronic - prevention & control Spironolactone - administration & dosage
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