Gold Coating of Silver Nanoplates for Enhanced Dispersion Stability and Efficient Antimicrobial Activity against Intracellular Bacteria

Gold Coating of Silver Nanoplates for Enhanced Dispersion Stability and Efficient Antimicrobial Activity against Intracellular Bacteria

Silver nanoparticles have antibacterial activity. However, the nanoparticles are unstable and easily form aggregates, which decreases their antibacterial activity. To improve the dispersion stability of silver nanoparticles in aqueous media and to increase their effectiveness as antibacterial agents...

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Veröffentlicht in:Langmuir 2018-09, Vol.34 (35), p.10413-10418
Hauptverfasser: Ichimaru, Hiroaki, Harada, Ayaka, Yoshimoto, Soichiro, Miyazawa, Yuta, Mizoguchi, Daigou, Kyaw, Kaung, Ono, Katsuhiko, Tsutsuki, Hiroyasu, Sawa, Tomohiro, Niidome, Takuro
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container_end_page 10418
container_issue 35
container_start_page 10413
container_title Langmuir
container_volume 34
creator Ichimaru, Hiroaki
Harada, Ayaka
Yoshimoto, Soichiro
Miyazawa, Yuta
Mizoguchi, Daigou
Kyaw, Kaung
Ono, Katsuhiko
Tsutsuki, Hiroyasu
Sawa, Tomohiro
Niidome, Takuro
description Silver nanoparticles have antibacterial activity. However, the nanoparticles are unstable and easily form aggregates, which decreases their antibacterial activity. To improve the dispersion stability of silver nanoparticles in aqueous media and to increase their effectiveness as antibacterial agents, we coated triangular plate-like silver nanoparticles (silver nanoplates, Ag NPLs) with one or two layers of gold atoms (Ag@Au1L NPLs and Ag@Au2L NPLs, respectively). These gold coatings improved the dispersion stability in aqueous media with high salt concentrations. Ag@Au1L NPLs showed stronger antibacterial activity on pathogenic bacteria than Ag NPLs and Ag@Au2L NPLs. Furthermore, the Ag@Au1L NPLs decreased the number of bacteria in RAW 264.7 cells. The Ag@Au1L NPLs displayed no cytotoxicity towards RAW 264.7 cells and could be used as antibacterial agents for intracellular bacterial infections.
doi_str_mv 10.1021/acs.langmuir.8b00540
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title Gold Coating of Silver Nanoplates for Enhanced Dispersion Stability and Efficient Antimicrobial Activity against Intracellular Bacteria
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