R‑Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator

The cystic fibrosis transmembrane conductance regulator (CFTR) is an asymmetric ATP-binding cassette transporter in which ATP hydrolysis occurs only at the second of the two composite nucleotide-binding sites whereas there are noncanonical substitutions of key catalytic residues in the first site. T...

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Veröffentlicht in:	Biochemistry (Easton) 2018-08, Vol.57 (34), p.5073-5075
Hauptverfasser:	Aleksandrov, Luba A, Fay, Jonathan F, Riordan, John R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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