Disruption of the homeostatic balance between autoaggressive (CD4 super(+)CD40 super(+)) and regulatory (CD4 super(+)CD25 super(+)FoxP3 super(+)) T cells promotes diabetes

Although regulatory T cells (Tregs) are well described, identifying autoaggressive effector T cells has proven more difficult. However, we identified CD4 super(10)CD40 super(+) (Th40) cells as being necessary and sufficient for diabetes in the NOD mouse model. Importantly, these cells are present in...

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Veröffentlicht in:	Journal of leukocyte biology 2008-08, Vol.84 (2), p.431-439
Hauptverfasser:	Waid, D M, Vaitaitis, G M, Pennock, N D, Wagner, DH Jr
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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