High levels of morphine-6-glucuronide in street heroin addicts

In the body, heroin is rapidly transformed to 6-acetylmorphine (6-AM) and then to morphine, that in turn is mainly metabolized to morphine-3-glucuronide (M3G) and, at lesser extent, to morphine-6-glucuronide (M6G). Unlike M3G, M6G is a potent opioid agonist. Intravenous heroin abusers (IHU) are expo...

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Veröffentlicht in:	Psychopharmacologia 2003-11, Vol.170 (2), p.200-204
Hauptverfasser:	ANTONILLI, Letizia, SEMERARO, Federico, SURIANO, Carmen, SIGNORE, Luciano, NENCINI, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Adult Adult and adolescent clinical studies Aged Analgesics, Opioid - administration & dosage Analysis of Variance Biological and medical sciences Chromatography, High Pressure Liquid Drug addiction Drug Administration Schedule Female Heroin - administration & dosage Heroin Dependence - blood Heroin Dependence - urine Humans Male Medical sciences Middle Aged Morphine - administration & dosage Morphine - blood Morphine - urine Morphine Derivatives - blood Morphine Derivatives - urine Narcotics - administration & dosage Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Time Factors
Online-Zugang:	Volltext
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