Lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine

Previous studies have reported that rats exposed to a binge-abstinence history of cocaine self-administration exhibit sensitization to the positive-reinforcing effects of cocaine on a progressive ratio (PR) schedule of reinforcement. The purpose of the present study was to determine whether lesions...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2008, Vol.88 (3), p.238-246
Hauptverfasser:	Smith, Mark A., Ward, Sara J., Roberts, David C.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cocaine Cocaine - pharmacology Conditioning, Operant - drug effects Conditioning, Operant - physiology Data Interpretation, Statistical Excitatory Amino Acid Agonists - toxicity Frontal cortex Ibotenic acid Ibotenic Acid - toxicity Lesion Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Positive reinforcement Prefrontal Cortex - injuries Prefrontal Cortex - pathology Prefrontal Cortex - physiology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rat Rats Rats, Sprague-Dawley Reinforcement (Psychology) Reinforcement Schedule Self Administration Sensitization Substance Withdrawal Syndrome - psychology
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