Dedifferentiation, transdifferentiation and cell fusion: in vivo reprogramming strategies for regenerative medicine
Regenerative capacities vary enormously across the animal kingdom. In contrast to most cold‐blooded vertebrates, mammals, including humans, have very limited regenerative capacity when it comes to repairing damaged or degenerating tissues. Here, we review the main mechanisms of tissue regeneration,...
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| Veröffentlicht in: | The FEBS journal 2019-03, Vol.286 (6), p.1074-1093 |
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| creator | Pesaresi, Martina Sebastian‐Perez, Ruben Cosma, Maria Pia |
| description | Regenerative capacities vary enormously across the animal kingdom. In contrast to most cold‐blooded vertebrates, mammals, including humans, have very limited regenerative capacity when it comes to repairing damaged or degenerating tissues. Here, we review the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation and reprogramming. We discuss the significance of cell fate and identity changes in the context of regenerative medicine, with a particular focus on strategies aiming at the promotion of the body's self‐repairing mechanisms. We also introduce some of the most recent advances that have resulted in complete reprogramming of cell identity in vivo. Lastly, we discuss the main challenges that need to be addressed in the near future to develop in vivo reprogramming approaches with therapeutic potential.
Regenerative capabilities vary enormously across the animal kingdom. In contrast to most cold‐blooded vertebrates, mammals have very limited regenerative capacity. In this review, we summarise the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation, transdifferentiation and cell fusion processes. We discuss the significance of cell fate changes in the context of regenerative medicine, highlighting some of the latest advances showing somatic cell reprogramming in vivo. |
| doi_str_mv | 10.1111/febs.14633 |
| format | Article |
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Regenerative capabilities vary enormously across the animal kingdom. In contrast to most cold‐blooded vertebrates, mammals have very limited regenerative capacity. In this review, we summarise the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation, transdifferentiation and cell fusion processes. We discuss the significance of cell fate changes in the context of regenerative medicine, highlighting some of the latest advances showing somatic cell reprogramming in vivo.</description><identifier>ISSN: 1742-464X</identifier><identifier>EISSN: 1742-4658</identifier><identifier>DOI: 10.1111/febs.14633</identifier><identifier>PMID: 30103260</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Cell Communication ; Cell Differentiation ; Cell fate ; Cell Fusion ; Cell Transdifferentiation ; Cellular Reprogramming ; dedifferentiation ; endogenous regeneration ; Humans ; Induced Pluripotent Stem Cells - cytology ; in vivo reprogramming ; Maintenance ; Medicine ; Regeneration (physiology) ; Regenerative Medicine ; Tissue engineering ; Vertebrates</subject><ispartof>The FEBS journal, 2019-03, Vol.286 (6), p.1074-1093</ispartof><rights>2018 Federation of European Biochemical Societies</rights><rights>2018 Federation of European Biochemical Societies.</rights><rights>Copyright © 2019 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4593-1fde71e0620c97af4f89b0678fa29defaa12c66866cdc84b32f20faaa2d96e303</citedby><cites>FETCH-LOGICAL-c4593-1fde71e0620c97af4f89b0678fa29defaa12c66866cdc84b32f20faaa2d96e303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ffebs.14633$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ffebs.14633$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30103260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pesaresi, Martina</creatorcontrib><creatorcontrib>Sebastian‐Perez, Ruben</creatorcontrib><creatorcontrib>Cosma, Maria Pia</creatorcontrib><title>Dedifferentiation, transdifferentiation and cell fusion: in vivo reprogramming strategies for regenerative medicine</title><title>The FEBS journal</title><addtitle>FEBS J</addtitle><description>Regenerative capacities vary enormously across the animal kingdom. In contrast to most cold‐blooded vertebrates, mammals, including humans, have very limited regenerative capacity when it comes to repairing damaged or degenerating tissues. Here, we review the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation and reprogramming. We discuss the significance of cell fate and identity changes in the context of regenerative medicine, with a particular focus on strategies aiming at the promotion of the body's self‐repairing mechanisms. We also introduce some of the most recent advances that have resulted in complete reprogramming of cell identity in vivo. Lastly, we discuss the main challenges that need to be addressed in the near future to develop in vivo reprogramming approaches with therapeutic potential.
Regenerative capabilities vary enormously across the animal kingdom. In contrast to most cold‐blooded vertebrates, mammals have very limited regenerative capacity. In this review, we summarise the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation, transdifferentiation and cell fusion processes. 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In contrast to most cold‐blooded vertebrates, mammals, including humans, have very limited regenerative capacity when it comes to repairing damaged or degenerating tissues. Here, we review the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation and reprogramming. We discuss the significance of cell fate and identity changes in the context of regenerative medicine, with a particular focus on strategies aiming at the promotion of the body's self‐repairing mechanisms. We also introduce some of the most recent advances that have resulted in complete reprogramming of cell identity in vivo. Lastly, we discuss the main challenges that need to be addressed in the near future to develop in vivo reprogramming approaches with therapeutic potential.
Regenerative capabilities vary enormously across the animal kingdom. In contrast to most cold‐blooded vertebrates, mammals have very limited regenerative capacity. In this review, we summarise the main mechanisms of tissue regeneration, underlying the importance of cell dedifferentiation, transdifferentiation and cell fusion processes. We discuss the significance of cell fate changes in the context of regenerative medicine, highlighting some of the latest advances showing somatic cell reprogramming in vivo.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30103260</pmid><doi>10.1111/febs.14633</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell Communication Cell Differentiation Cell fate Cell Fusion Cell Transdifferentiation Cellular Reprogramming dedifferentiation endogenous regeneration Humans Induced Pluripotent Stem Cells - cytology in vivo reprogramming Maintenance Medicine Regeneration (physiology) Regenerative Medicine Tissue engineering Vertebrates |
| title | Dedifferentiation, transdifferentiation and cell fusion: in vivo reprogramming strategies for regenerative medicine |
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