Radiotherapy for the treatment of distant nodes metastases from oligometastatic urothelial cancer: A retrospective case series
Objectives To investigate the efficacy of stereotactic body radiotherapy in oligometastatic urothelial carcinoma with node‐only involvement. Methods We retrospectively collected data on the outcomes of patients who underwent stereotactic body radiotherapy for metastatic node lesions from oligometast...
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| Veröffentlicht in: | International journal of urology 2018-10, Vol.25 (10), p.879-886 |
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| creator | Leonetti, Alessandro D'Abbiero, Nunziata Baldari, Giorgio Andreani, Stefano Ruffini, Livia Viansone, Alessandro A Buti, Sebastiano |
| description | Objectives
To investigate the efficacy of stereotactic body radiotherapy in oligometastatic urothelial carcinoma with node‐only involvement.
Methods
We retrospectively collected data on the outcomes of patients who underwent stereotactic body radiotherapy for metastatic node lesions from oligometastatic urothelial carcinoma at Radiotherapy Unit of University Hospital of Parma, Parma, Italy. The investigated outcomes were lesion size, standardized uptake value, overall response rate, lesion control rate, lesion progression‐free interval, progression‐free survival and overall survival.
Results
Among seven patients included in the study, a total of 14 node metastatic lesions were treated with stereotactic body radiotherapy. The mean total dose of stereotactic body radiotherapy was 32 Gy (range 25–40 Gy). At first imaging evaluation, a mean variation of −4% (P = 0.427) in major diameter, −16% (P = 0.048) in minor diameter and –76% in standardized uptake value (P |
| doi_str_mv | 10.1111/iju.13773 |
| format | Article |
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To investigate the efficacy of stereotactic body radiotherapy in oligometastatic urothelial carcinoma with node‐only involvement.
Methods
We retrospectively collected data on the outcomes of patients who underwent stereotactic body radiotherapy for metastatic node lesions from oligometastatic urothelial carcinoma at Radiotherapy Unit of University Hospital of Parma, Parma, Italy. The investigated outcomes were lesion size, standardized uptake value, overall response rate, lesion control rate, lesion progression‐free interval, progression‐free survival and overall survival.
Results
Among seven patients included in the study, a total of 14 node metastatic lesions were treated with stereotactic body radiotherapy. The mean total dose of stereotactic body radiotherapy was 32 Gy (range 25–40 Gy). At first imaging evaluation, a mean variation of −4% (P = 0.427) in major diameter, −16% (P = 0.048) in minor diameter and –76% in standardized uptake value (P < 0.001) were documented. The overall response rate and lesion control rate were 43% and 100%, respectively. Median lesion progression‐free interval, progression‐free survival and overall survival were 11.4 months (95% CI 3.4–19.4), 2.9 months (95% CI 2.6–3.1) and 14.9 months (95% CI 12.3–17.5), respectively. Stereotactic body radiotherapy was effective in delaying the beginning of a systemic chemotherapy in four patients.
Conclusions
The present findings generate the hypothesis of a possible role for the use of stereotactic body radiotherapy in selected patients with distant node metastases from oligometastatic urothelial carcinoma.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.13773</identifier><identifier>PMID: 30103254</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Aged ; Carcinoma, Transitional Cell - mortality ; Carcinoma, Transitional Cell - radiotherapy ; Carcinoma, Transitional Cell - secondary ; Chemotherapy ; Disease Progression ; Disease-Free Survival ; Female ; Humans ; Italy ; Kaplan-Meier Estimate ; lymph node metastases ; Lymph Nodes - pathology ; Lymph Nodes - radiation effects ; Lymphatic Metastasis - pathology ; Lymphatic Metastasis - radiotherapy ; Male ; Metastases ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local ; oligometastatic urothelial cancer ; Patients ; Progression-Free Survival ; Radiation therapy ; Radiosurgery ; Response rates ; Retrospective Studies ; stereotactic body radiotherapy ; Survival ; Time Factors ; Urinary Bladder Neoplasms - mortality ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - radiotherapy ; Urothelial cancer ; Urothelial carcinoma</subject><ispartof>International journal of urology, 2018-10, Vol.25 (10), p.879-886</ispartof><rights>2018 The Japanese Urological Association</rights><rights>2018 The Japanese Urological Association.</rights><rights>Copyright © 2018 The Japanese Urological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4123-af5b911b9591187539484192ebd2c579f20107c653b1c675739f10cb2a60bd8c3</citedby><cites>FETCH-LOGICAL-c4123-af5b911b9591187539484192ebd2c579f20107c653b1c675739f10cb2a60bd8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.13773$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.13773$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30103254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leonetti, Alessandro</creatorcontrib><creatorcontrib>D'Abbiero, Nunziata</creatorcontrib><creatorcontrib>Baldari, Giorgio</creatorcontrib><creatorcontrib>Andreani, Stefano</creatorcontrib><creatorcontrib>Ruffini, Livia</creatorcontrib><creatorcontrib>Viansone, Alessandro A</creatorcontrib><creatorcontrib>Buti, Sebastiano</creatorcontrib><title>Radiotherapy for the treatment of distant nodes metastases from oligometastatic urothelial cancer: A retrospective case series</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objectives
To investigate the efficacy of stereotactic body radiotherapy in oligometastatic urothelial carcinoma with node‐only involvement.
Methods
We retrospectively collected data on the outcomes of patients who underwent stereotactic body radiotherapy for metastatic node lesions from oligometastatic urothelial carcinoma at Radiotherapy Unit of University Hospital of Parma, Parma, Italy. The investigated outcomes were lesion size, standardized uptake value, overall response rate, lesion control rate, lesion progression‐free interval, progression‐free survival and overall survival.
Results
Among seven patients included in the study, a total of 14 node metastatic lesions were treated with stereotactic body radiotherapy. The mean total dose of stereotactic body radiotherapy was 32 Gy (range 25–40 Gy). At first imaging evaluation, a mean variation of −4% (P = 0.427) in major diameter, −16% (P = 0.048) in minor diameter and –76% in standardized uptake value (P < 0.001) were documented. The overall response rate and lesion control rate were 43% and 100%, respectively. Median lesion progression‐free interval, progression‐free survival and overall survival were 11.4 months (95% CI 3.4–19.4), 2.9 months (95% CI 2.6–3.1) and 14.9 months (95% CI 12.3–17.5), respectively. Stereotactic body radiotherapy was effective in delaying the beginning of a systemic chemotherapy in four patients.
Conclusions
The present findings generate the hypothesis of a possible role for the use of stereotactic body radiotherapy in selected patients with distant node metastases from oligometastatic urothelial carcinoma.</description><subject>Aged</subject><subject>Carcinoma, Transitional Cell - mortality</subject><subject>Carcinoma, Transitional Cell - radiotherapy</subject><subject>Carcinoma, Transitional Cell - secondary</subject><subject>Chemotherapy</subject><subject>Disease Progression</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Italy</subject><subject>Kaplan-Meier Estimate</subject><subject>lymph node metastases</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - radiation effects</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic Metastasis - radiotherapy</subject><subject>Male</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>oligometastatic urothelial cancer</subject><subject>Patients</subject><subject>Progression-Free Survival</subject><subject>Radiation therapy</subject><subject>Radiosurgery</subject><subject>Response rates</subject><subject>Retrospective Studies</subject><subject>stereotactic body radiotherapy</subject><subject>Survival</subject><subject>Time Factors</subject><subject>Urinary Bladder Neoplasms - mortality</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - radiotherapy</subject><subject>Urothelial cancer</subject><subject>Urothelial carcinoma</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFP3DAQha2qFWwXDv0DlaVeyiHgGSebuDeESgtCqlSVs-U4k9arJN7aTtFe-O0YdssBCR_s59Gnp5l5jH0AcQr5nLn1fAqyruUbtoCyxAJFiW_ZQihQRQM1HrL3Ma6FAInQHLBDKUBIrMoFu_9pOufTHwpms-W9DzxrngKZNNKUuO9552IyWU6-o8hHSib_Y5Z98CP3g_vt98XkLJ_Do9vgzMCtmSyFL_ycB0rBxw3Z5P5RrkfikYKjeMTe9WaIdLx_l-z28uuvi-_FzY9vVxfnN4UtAWVh-qpVAK2q8t3UlVRlU4JCaju0Va16zAPVdlXJFuyqrmqpehC2RbMSbddYuWSfd76b4P_OFJMeXbQ0DGYiP0eNomlQwSqvZck-vUDXfg5T7k4jQIWIZd70kp3sKJsHi4F6vQluNGGrQejHUHQORT-FktmPe8e5Hal7Jv-nkIGzHXDnBtq-7qSvrm93lg9E05bc</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Leonetti, Alessandro</creator><creator>D'Abbiero, Nunziata</creator><creator>Baldari, Giorgio</creator><creator>Andreani, Stefano</creator><creator>Ruffini, Livia</creator><creator>Viansone, Alessandro A</creator><creator>Buti, Sebastiano</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Radiotherapy for the treatment of distant nodes metastases from oligometastatic urothelial cancer: A retrospective case series</title><author>Leonetti, Alessandro ; D'Abbiero, Nunziata ; Baldari, Giorgio ; Andreani, Stefano ; Ruffini, Livia ; Viansone, Alessandro A ; Buti, Sebastiano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4123-af5b911b9591187539484192ebd2c579f20107c653b1c675739f10cb2a60bd8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Carcinoma, Transitional Cell - mortality</topic><topic>Carcinoma, Transitional Cell - radiotherapy</topic><topic>Carcinoma, Transitional Cell - secondary</topic><topic>Chemotherapy</topic><topic>Disease Progression</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Italy</topic><topic>Kaplan-Meier Estimate</topic><topic>lymph node metastases</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - radiation effects</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic Metastasis - radiotherapy</topic><topic>Male</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>oligometastatic urothelial cancer</topic><topic>Patients</topic><topic>Progression-Free Survival</topic><topic>Radiation therapy</topic><topic>Radiosurgery</topic><topic>Response rates</topic><topic>Retrospective Studies</topic><topic>stereotactic body radiotherapy</topic><topic>Survival</topic><topic>Time Factors</topic><topic>Urinary Bladder Neoplasms - mortality</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - radiotherapy</topic><topic>Urothelial cancer</topic><topic>Urothelial carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leonetti, Alessandro</creatorcontrib><creatorcontrib>D'Abbiero, Nunziata</creatorcontrib><creatorcontrib>Baldari, Giorgio</creatorcontrib><creatorcontrib>Andreani, Stefano</creatorcontrib><creatorcontrib>Ruffini, Livia</creatorcontrib><creatorcontrib>Viansone, Alessandro A</creatorcontrib><creatorcontrib>Buti, Sebastiano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leonetti, Alessandro</au><au>D'Abbiero, Nunziata</au><au>Baldari, Giorgio</au><au>Andreani, Stefano</au><au>Ruffini, Livia</au><au>Viansone, Alessandro A</au><au>Buti, Sebastiano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiotherapy for the treatment of distant nodes metastases from oligometastatic urothelial cancer: A retrospective case series</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2018-10</date><risdate>2018</risdate><volume>25</volume><issue>10</issue><spage>879</spage><epage>886</epage><pages>879-886</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To investigate the efficacy of stereotactic body radiotherapy in oligometastatic urothelial carcinoma with node‐only involvement.
Methods
We retrospectively collected data on the outcomes of patients who underwent stereotactic body radiotherapy for metastatic node lesions from oligometastatic urothelial carcinoma at Radiotherapy Unit of University Hospital of Parma, Parma, Italy. The investigated outcomes were lesion size, standardized uptake value, overall response rate, lesion control rate, lesion progression‐free interval, progression‐free survival and overall survival.
Results
Among seven patients included in the study, a total of 14 node metastatic lesions were treated with stereotactic body radiotherapy. The mean total dose of stereotactic body radiotherapy was 32 Gy (range 25–40 Gy). At first imaging evaluation, a mean variation of −4% (P = 0.427) in major diameter, −16% (P = 0.048) in minor diameter and –76% in standardized uptake value (P < 0.001) were documented. The overall response rate and lesion control rate were 43% and 100%, respectively. Median lesion progression‐free interval, progression‐free survival and overall survival were 11.4 months (95% CI 3.4–19.4), 2.9 months (95% CI 2.6–3.1) and 14.9 months (95% CI 12.3–17.5), respectively. Stereotactic body radiotherapy was effective in delaying the beginning of a systemic chemotherapy in four patients.
Conclusions
The present findings generate the hypothesis of a possible role for the use of stereotactic body radiotherapy in selected patients with distant node metastases from oligometastatic urothelial carcinoma.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30103254</pmid><doi>10.1111/iju.13773</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of urology, 2018-10, Vol.25 (10), p.879-886 |
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| subjects | Aged Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - radiotherapy Carcinoma, Transitional Cell - secondary Chemotherapy Disease Progression Disease-Free Survival Female Humans Italy Kaplan-Meier Estimate lymph node metastases Lymph Nodes - pathology Lymph Nodes - radiation effects Lymphatic Metastasis - pathology Lymphatic Metastasis - radiotherapy Male Metastases Metastasis Middle Aged Neoplasm Recurrence, Local oligometastatic urothelial cancer Patients Progression-Free Survival Radiation therapy Radiosurgery Response rates Retrospective Studies stereotactic body radiotherapy Survival Time Factors Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - radiotherapy Urothelial cancer Urothelial carcinoma |
| title | Radiotherapy for the treatment of distant nodes metastases from oligometastatic urothelial cancer: A retrospective case series |
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