Acne: a side‐effect of masculinizing hormonal therapy in transgender patients
Summary Background Masculinizing hormonal treatment in transgender men has the potential to increase the level of androgens at end organs, including the pilosebaceous unit. Androgen‐induced sebocyte growth and differentiation, sebum production and infundibular keratinization may underlie the develop...
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| Veröffentlicht in: | British journal of dermatology (1951) 2019-01, Vol.180 (1), p.26-30 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 180 |
| creator | Motosko, C.C. Zakhem, G.A. Pomeranz, M.K. Hazen, A. |
| description | Summary
Background
Masculinizing hormonal treatment in transgender men has the potential to increase the level of androgens at end organs, including the pilosebaceous unit. Androgen‐induced sebocyte growth and differentiation, sebum production and infundibular keratinization may underlie the development of acne vulgaris among patients receiving this therapy.
Objectives
The aim of this article is to familiarize dermatologists with the sensitivities and challenges of treating acne in transgender male individuals.
Methods
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and highlights the unique considerations in treating this underserved patient population.
Results
Despite the incidence of treatment‐related acne and the unique considerations in treating transgender men, studies addressing this topic among this patient population are limited.
Conclusions
Generally, the standard guidelines for the treatment of acne can be followed in treating these patients; however, several medical, social and psychological factors should be considered.
What's already known about this topic?
Acne vulgaris is a known side‐effect of masculinizing hormonal therapy.
Treatment with isotretinoin in these patients poses several ethical challenges.
What does this study add?
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy.
This article highlights the unique considerations in treating this underserved patient population.
Plain language summary available online |
| doi_str_mv | 10.1111/bjd.17083 |
| format | Article |
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Background
Masculinizing hormonal treatment in transgender men has the potential to increase the level of androgens at end organs, including the pilosebaceous unit. Androgen‐induced sebocyte growth and differentiation, sebum production and infundibular keratinization may underlie the development of acne vulgaris among patients receiving this therapy.
Objectives
The aim of this article is to familiarize dermatologists with the sensitivities and challenges of treating acne in transgender male individuals.
Methods
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and highlights the unique considerations in treating this underserved patient population.
Results
Despite the incidence of treatment‐related acne and the unique considerations in treating transgender men, studies addressing this topic among this patient population are limited.
Conclusions
Generally, the standard guidelines for the treatment of acne can be followed in treating these patients; however, several medical, social and psychological factors should be considered.
What's already known about this topic?
Acne vulgaris is a known side‐effect of masculinizing hormonal therapy.
Treatment with isotretinoin in these patients poses several ethical challenges.
What does this study add?
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy.
This article highlights the unique considerations in treating this underserved patient population.
Plain language summary available online</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/bjd.17083</identifier><identifier>PMID: 30101531</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Acne ; Androgens ; Endocrine therapy ; Keratinization ; Patients ; Side effects ; Testosterone ; Transgender persons</subject><ispartof>British journal of dermatology (1951), 2019-01, Vol.180 (1), p.26-30</ispartof><rights>2018 British Association of Dermatologists</rights><rights>2018 British Association of Dermatologists.</rights><rights>Copyright © 2019 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-ba5ea2d398c68b29aebc7292af9ebeb925e4abc645e65ac5bbd2037af4aae8103</citedby><cites>FETCH-LOGICAL-c3883-ba5ea2d398c68b29aebc7292af9ebeb925e4abc645e65ac5bbd2037af4aae8103</cites><orcidid>0000-0003-3244-3976 ; 0000-0002-5675-574X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjd.17083$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjd.17083$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30101531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motosko, C.C.</creatorcontrib><creatorcontrib>Zakhem, G.A.</creatorcontrib><creatorcontrib>Pomeranz, M.K.</creatorcontrib><creatorcontrib>Hazen, A.</creatorcontrib><title>Acne: a side‐effect of masculinizing hormonal therapy in transgender patients</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background
Masculinizing hormonal treatment in transgender men has the potential to increase the level of androgens at end organs, including the pilosebaceous unit. Androgen‐induced sebocyte growth and differentiation, sebum production and infundibular keratinization may underlie the development of acne vulgaris among patients receiving this therapy.
Objectives
The aim of this article is to familiarize dermatologists with the sensitivities and challenges of treating acne in transgender male individuals.
Methods
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and highlights the unique considerations in treating this underserved patient population.
Results
Despite the incidence of treatment‐related acne and the unique considerations in treating transgender men, studies addressing this topic among this patient population are limited.
Conclusions
Generally, the standard guidelines for the treatment of acne can be followed in treating these patients; however, several medical, social and psychological factors should be considered.
What's already known about this topic?
Acne vulgaris is a known side‐effect of masculinizing hormonal therapy.
Treatment with isotretinoin in these patients poses several ethical challenges.
What does this study add?
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy.
This article highlights the unique considerations in treating this underserved patient population.
Plain language summary available online</description><subject>Acne</subject><subject>Androgens</subject><subject>Endocrine therapy</subject><subject>Keratinization</subject><subject>Patients</subject><subject>Side effects</subject><subject>Testosterone</subject><subject>Transgender persons</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10M1O3DAUhmELFcEwdMENIEvdlEVm_DN2HHZ0gAJCYtOuo2PnBDxKnKmdqJqueglcI1dC6EAXSHjjzaNXOh8hR5zN-PjmdlXNeM6M3CETLrXKBJfyE5kwxvKMFVruk4OUVoxxyRTbI_uSccaV5BNyd-YCnlKgyVf49PcR6xpdT7uatpDc0Pjg__hwTx-62HYBGto_YIT1hvpA-wgh3WOoMNI19B5Dnw7Jbg1Nws-v_5T8vLz4sbzKbu--Xy_PbjMnjZGZBYUgKlkYp40VBaB1uSgE1AVatIVQuADr9EKhVuCUtZVgMod6AYCGMzklX7fddex-DZj6svXJYdNAwG5IpWAmLwq1MGqkX97RVTfE8ZZRcS200VrzUZ1slYtdShHrch19C3FTcla-rFyOK5f_Vh7t8WtxsC1W_-XbrCOYb8Fv3-Dm41L57eZ8m3wGceaHZA</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Motosko, C.C.</creator><creator>Zakhem, G.A.</creator><creator>Pomeranz, M.K.</creator><creator>Hazen, A.</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3244-3976</orcidid><orcidid>https://orcid.org/0000-0002-5675-574X</orcidid></search><sort><creationdate>201901</creationdate><title>Acne: a side‐effect of masculinizing hormonal therapy in transgender patients</title><author>Motosko, C.C. ; Zakhem, G.A. ; Pomeranz, M.K. ; Hazen, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-ba5ea2d398c68b29aebc7292af9ebeb925e4abc645e65ac5bbd2037af4aae8103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acne</topic><topic>Androgens</topic><topic>Endocrine therapy</topic><topic>Keratinization</topic><topic>Patients</topic><topic>Side effects</topic><topic>Testosterone</topic><topic>Transgender persons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motosko, C.C.</creatorcontrib><creatorcontrib>Zakhem, G.A.</creatorcontrib><creatorcontrib>Pomeranz, M.K.</creatorcontrib><creatorcontrib>Hazen, A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motosko, C.C.</au><au>Zakhem, G.A.</au><au>Pomeranz, M.K.</au><au>Hazen, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acne: a side‐effect of masculinizing hormonal therapy in transgender patients</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2019-01</date><risdate>2019</risdate><volume>180</volume><issue>1</issue><spage>26</spage><epage>30</epage><pages>26-30</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>Summary
Background
Masculinizing hormonal treatment in transgender men has the potential to increase the level of androgens at end organs, including the pilosebaceous unit. Androgen‐induced sebocyte growth and differentiation, sebum production and infundibular keratinization may underlie the development of acne vulgaris among patients receiving this therapy.
Objectives
The aim of this article is to familiarize dermatologists with the sensitivities and challenges of treating acne in transgender male individuals.
Methods
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and highlights the unique considerations in treating this underserved patient population.
Results
Despite the incidence of treatment‐related acne and the unique considerations in treating transgender men, studies addressing this topic among this patient population are limited.
Conclusions
Generally, the standard guidelines for the treatment of acne can be followed in treating these patients; however, several medical, social and psychological factors should be considered.
What's already known about this topic?
Acne vulgaris is a known side‐effect of masculinizing hormonal therapy.
Treatment with isotretinoin in these patients poses several ethical challenges.
What does this study add?
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy.
This article highlights the unique considerations in treating this underserved patient population.
Plain language summary available online</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30101531</pmid><doi>10.1111/bjd.17083</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3244-3976</orcidid><orcidid>https://orcid.org/0000-0002-5675-574X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | British journal of dermatology (1951), 2019-01, Vol.180 (1), p.26-30 |
| issn | 0007-0963 1365-2133 |
| language | eng |
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| source | Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Acne Androgens Endocrine therapy Keratinization Patients Side effects Testosterone Transgender persons |
| title | Acne: a side‐effect of masculinizing hormonal therapy in transgender patients |
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