Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes

[Display omitted] We described the discovery and optimization of a novel series of pyrimidopyrimidine derivatives as G-protein coupled receptor 119 (GPR119) agonists against type 2 diabetes. Most designed compounds displayed significant GPR119 agonistic activities. Optimized analogues 15a and 21e ex...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-08, Vol.26 (14), p.4080-4087
Hauptverfasser:	Fang, Yuanying, Xu, Jun, Li, Zhifeng, Yang, Zunhua, Xiong, Lijuan, Jin, Yi, Wang, Qi, Xie, Saisai, Zhu, Wufu, Chang, Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology CHO Cells Cricetulus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - drug therapy Dose-Response Relationship, Drug Drug Design Glucose Tolerance Test GPR119 agonist Mice Mice, Inbred C57BL Molecular Structure oGTT Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Pyrimido[5,4-d]pyrimidine Receptors, G-Protein-Coupled - agonists Structure-Activity Relationship Type 2 diabetes
Online-Zugang:	Volltext
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