Importance of bioavailable calcium in fluoride dentifrices for enamel remineralization
To compare remineralization of enamel subsurface lesions by fluoride dentifrices with added calcium in a double-blind, randomized, cross-over, in situ study. Human enamel with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1 g toothpaste/4 ml H...
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| Veröffentlicht in: | Journal of dentistry 2018-11, Vol.78, p.59-64 |
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| creator | Shen, Peiyan Walker, Glenn D. Yuan, Yi Reynolds, Coralie Stanton, David P. Fernando, James R. Reynolds, Eric C. |
| description | To compare remineralization of enamel subsurface lesions by fluoride dentifrices with added calcium in a double-blind, randomized, cross-over, in situ study.
Human enamel with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1 g toothpaste/4 ml H2O) was rinsed for 60 s, 4 times per day for 14 days. Seven toothpastes were tested: (i) 1450 ppm F (NaF), (ii) 5000 ppm F (NaF), (iii) 1450 ppm F (MFP) with calcium sodium phosphosilicate (CSP), (iv) 1450 ppm F (MFP) with CaCO3/Arg, (v) 1150 ppm F (SnF2) with amorphous calcium phosphate (ACP), (vi) 1100 ppm F (NaF) with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and (vii) 5000 ppm F (NaF) with functionalized tri-calcium phosphate (TCP). Total (acid soluble) and bioavailable (water soluble) calcium, inorganic phosphate and fluoride levels of the dentifrices were measured using ion chromatography (F/MFP) and spectrophotometry (Ca and inorganic phosphate). Enamel lesion mineral content was measured using transverse microradiography. Data were statistically analysed using a linear mixed model.
All calcium and fluoride containing toothpastes released > 90% of bioavailable fluoride and were superior to the respective fluoride alone toothpastes in remineralization of enamel subsurface lesions. The level of remineralization followed the order: CPP-ACP/1l00 ppm F > ACP/1150 ppm F = TCP/5000 ppm F > 5000 ppm F = CaCO3/Arg/1450 ppm F = CSP/1450 ppm F > 1450 ppm F. Bioavailable calcium levels significantly correlated with enhanced remineralization of enamel subsurface lesions.
Bioavailable calcium in fluoride dentifrices enhanced remineralization of enamel subsurface lesions. |
| doi_str_mv | 10.1016/j.jdent.2018.08.005 |
| format | Article |
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Human enamel with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1 g toothpaste/4 ml H2O) was rinsed for 60 s, 4 times per day for 14 days. Seven toothpastes were tested: (i) 1450 ppm F (NaF), (ii) 5000 ppm F (NaF), (iii) 1450 ppm F (MFP) with calcium sodium phosphosilicate (CSP), (iv) 1450 ppm F (MFP) with CaCO3/Arg, (v) 1150 ppm F (SnF2) with amorphous calcium phosphate (ACP), (vi) 1100 ppm F (NaF) with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and (vii) 5000 ppm F (NaF) with functionalized tri-calcium phosphate (TCP). Total (acid soluble) and bioavailable (water soluble) calcium, inorganic phosphate and fluoride levels of the dentifrices were measured using ion chromatography (F/MFP) and spectrophotometry (Ca and inorganic phosphate). Enamel lesion mineral content was measured using transverse microradiography. Data were statistically analysed using a linear mixed model.
All calcium and fluoride containing toothpastes released > 90% of bioavailable fluoride and were superior to the respective fluoride alone toothpastes in remineralization of enamel subsurface lesions. The level of remineralization followed the order: CPP-ACP/1l00 ppm F > ACP/1150 ppm F = TCP/5000 ppm F > 5000 ppm F = CaCO3/Arg/1450 ppm F = CSP/1450 ppm F > 1450 ppm F. Bioavailable calcium levels significantly correlated with enhanced remineralization of enamel subsurface lesions.
Bioavailable calcium in fluoride dentifrices enhanced remineralization of enamel subsurface lesions.</description><identifier>ISSN: 0300-5712</identifier><identifier>EISSN: 1879-176X</identifier><identifier>DOI: 10.1016/j.jdent.2018.08.005</identifier><identifier>PMID: 30099066</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Bioavailability ; Biological availability ; Calcium carbonate ; Calcium fluoride ; Calcium phosphates ; Casein ; Crossovers ; Data processing ; Dental caries ; Dental enamel ; Dentifrices ; Dentistry ; Enamel ; Fluoride treatments ; Fluorides ; Lesions ; Microradiography ; Phosphate ; Remineralization ; Slurries ; Sodium ; Sodium fluoride ; Spectrophotometry ; Toothpaste ; Toothpastes</subject><ispartof>Journal of dentistry, 2018-11, Vol.78, p.59-64</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-81f995666b95c53a98c7a4c582e086e2a6bc819d7c03f7d89aac44c87b4490bd3</citedby><cites>FETCH-LOGICAL-c453t-81f995666b95c53a98c7a4c582e086e2a6bc819d7c03f7d89aac44c87b4490bd3</cites><orcidid>0000-0002-5788-1676 ; 0000-0002-6618-4856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0300571218302860$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30099066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Peiyan</creatorcontrib><creatorcontrib>Walker, Glenn D.</creatorcontrib><creatorcontrib>Yuan, Yi</creatorcontrib><creatorcontrib>Reynolds, Coralie</creatorcontrib><creatorcontrib>Stanton, David P.</creatorcontrib><creatorcontrib>Fernando, James R.</creatorcontrib><creatorcontrib>Reynolds, Eric C.</creatorcontrib><title>Importance of bioavailable calcium in fluoride dentifrices for enamel remineralization</title><title>Journal of dentistry</title><addtitle>J Dent</addtitle><description>To compare remineralization of enamel subsurface lesions by fluoride dentifrices with added calcium in a double-blind, randomized, cross-over, in situ study.
Human enamel with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1 g toothpaste/4 ml H2O) was rinsed for 60 s, 4 times per day for 14 days. Seven toothpastes were tested: (i) 1450 ppm F (NaF), (ii) 5000 ppm F (NaF), (iii) 1450 ppm F (MFP) with calcium sodium phosphosilicate (CSP), (iv) 1450 ppm F (MFP) with CaCO3/Arg, (v) 1150 ppm F (SnF2) with amorphous calcium phosphate (ACP), (vi) 1100 ppm F (NaF) with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and (vii) 5000 ppm F (NaF) with functionalized tri-calcium phosphate (TCP). Total (acid soluble) and bioavailable (water soluble) calcium, inorganic phosphate and fluoride levels of the dentifrices were measured using ion chromatography (F/MFP) and spectrophotometry (Ca and inorganic phosphate). Enamel lesion mineral content was measured using transverse microradiography. Data were statistically analysed using a linear mixed model.
All calcium and fluoride containing toothpastes released > 90% of bioavailable fluoride and were superior to the respective fluoride alone toothpastes in remineralization of enamel subsurface lesions. The level of remineralization followed the order: CPP-ACP/1l00 ppm F > ACP/1150 ppm F = TCP/5000 ppm F > 5000 ppm F = CaCO3/Arg/1450 ppm F = CSP/1450 ppm F > 1450 ppm F. Bioavailable calcium levels significantly correlated with enhanced remineralization of enamel subsurface lesions.
Bioavailable calcium in fluoride dentifrices enhanced remineralization of enamel subsurface lesions.</description><subject>Bioavailability</subject><subject>Biological availability</subject><subject>Calcium carbonate</subject><subject>Calcium fluoride</subject><subject>Calcium phosphates</subject><subject>Casein</subject><subject>Crossovers</subject><subject>Data processing</subject><subject>Dental caries</subject><subject>Dental enamel</subject><subject>Dentifrices</subject><subject>Dentistry</subject><subject>Enamel</subject><subject>Fluoride treatments</subject><subject>Fluorides</subject><subject>Lesions</subject><subject>Microradiography</subject><subject>Phosphate</subject><subject>Remineralization</subject><subject>Slurries</subject><subject>Sodium</subject><subject>Sodium fluoride</subject><subject>Spectrophotometry</subject><subject>Toothpaste</subject><subject>Toothpastes</subject><issn>0300-5712</issn><issn>1879-176X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMFq3DAQhkVI6W63fYJAEOSSizcjW5alQw8lJE0gkEsbchOyPAYZ2dpKdqB5-mq7mx5yKAwMDN8_M3yEnDHYMmDiatgOHU7ztgQmt5AL6hOyZrJRBWvE8ylZQwVQ1A0rV-RTSgMAcCjVR7LKc6VAiDV5uh93Ic5mskhDT1sXzItx3rQeqTXeumWkbqK9X0J0HdL9RddHZzHRPkSKkxnR04ijmzAa717N7ML0mXzojU_45dg35OftzY_ru-Lh8fv99beHwvK6mgvJeqVqIUSraltXRknbGG5rWSJIgaURrZVMdY2Fqm86qYyxnFvZtJwraLtqQy4Pe3cx_FowzXp0yaL3ZsKwJF1C1qEqWVYZvXiHDmGJU_5Ol4xlSZxxlqnqQNkYUorY6110o4m_NQO9164H_Ve73mvXkAvqnDo_7l7aEbt_mTfPGfh6ADDLeHEYdbIOs_TORbSz7oL774E_QNeUug</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Shen, Peiyan</creator><creator>Walker, Glenn D.</creator><creator>Yuan, Yi</creator><creator>Reynolds, Coralie</creator><creator>Stanton, David P.</creator><creator>Fernando, James R.</creator><creator>Reynolds, Eric C.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5788-1676</orcidid><orcidid>https://orcid.org/0000-0002-6618-4856</orcidid></search><sort><creationdate>201811</creationdate><title>Importance of bioavailable calcium in fluoride dentifrices for enamel remineralization</title><author>Shen, Peiyan ; Walker, Glenn D. ; Yuan, Yi ; Reynolds, Coralie ; Stanton, David P. ; Fernando, James R. ; Reynolds, Eric C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-81f995666b95c53a98c7a4c582e086e2a6bc819d7c03f7d89aac44c87b4490bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bioavailability</topic><topic>Biological availability</topic><topic>Calcium carbonate</topic><topic>Calcium fluoride</topic><topic>Calcium phosphates</topic><topic>Casein</topic><topic>Crossovers</topic><topic>Data processing</topic><topic>Dental caries</topic><topic>Dental enamel</topic><topic>Dentifrices</topic><topic>Dentistry</topic><topic>Enamel</topic><topic>Fluoride treatments</topic><topic>Fluorides</topic><topic>Lesions</topic><topic>Microradiography</topic><topic>Phosphate</topic><topic>Remineralization</topic><topic>Slurries</topic><topic>Sodium</topic><topic>Sodium fluoride</topic><topic>Spectrophotometry</topic><topic>Toothpaste</topic><topic>Toothpastes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Peiyan</creatorcontrib><creatorcontrib>Walker, Glenn D.</creatorcontrib><creatorcontrib>Yuan, Yi</creatorcontrib><creatorcontrib>Reynolds, Coralie</creatorcontrib><creatorcontrib>Stanton, David P.</creatorcontrib><creatorcontrib>Fernando, James R.</creatorcontrib><creatorcontrib>Reynolds, Eric C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Peiyan</au><au>Walker, Glenn D.</au><au>Yuan, Yi</au><au>Reynolds, Coralie</au><au>Stanton, David P.</au><au>Fernando, James R.</au><au>Reynolds, Eric C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Importance of bioavailable calcium in fluoride dentifrices for enamel remineralization</atitle><jtitle>Journal of dentistry</jtitle><addtitle>J Dent</addtitle><date>2018-11</date><risdate>2018</risdate><volume>78</volume><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>0300-5712</issn><eissn>1879-176X</eissn><abstract>To compare remineralization of enamel subsurface lesions by fluoride dentifrices with added calcium in a double-blind, randomized, cross-over, in situ study.
Human enamel with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1 g toothpaste/4 ml H2O) was rinsed for 60 s, 4 times per day for 14 days. Seven toothpastes were tested: (i) 1450 ppm F (NaF), (ii) 5000 ppm F (NaF), (iii) 1450 ppm F (MFP) with calcium sodium phosphosilicate (CSP), (iv) 1450 ppm F (MFP) with CaCO3/Arg, (v) 1150 ppm F (SnF2) with amorphous calcium phosphate (ACP), (vi) 1100 ppm F (NaF) with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and (vii) 5000 ppm F (NaF) with functionalized tri-calcium phosphate (TCP). Total (acid soluble) and bioavailable (water soluble) calcium, inorganic phosphate and fluoride levels of the dentifrices were measured using ion chromatography (F/MFP) and spectrophotometry (Ca and inorganic phosphate). Enamel lesion mineral content was measured using transverse microradiography. Data were statistically analysed using a linear mixed model.
All calcium and fluoride containing toothpastes released > 90% of bioavailable fluoride and were superior to the respective fluoride alone toothpastes in remineralization of enamel subsurface lesions. The level of remineralization followed the order: CPP-ACP/1l00 ppm F > ACP/1150 ppm F = TCP/5000 ppm F > 5000 ppm F = CaCO3/Arg/1450 ppm F = CSP/1450 ppm F > 1450 ppm F. Bioavailable calcium levels significantly correlated with enhanced remineralization of enamel subsurface lesions.
Bioavailable calcium in fluoride dentifrices enhanced remineralization of enamel subsurface lesions.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30099066</pmid><doi>10.1016/j.jdent.2018.08.005</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5788-1676</orcidid><orcidid>https://orcid.org/0000-0002-6618-4856</orcidid></addata></record> |
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| subjects | Bioavailability Biological availability Calcium carbonate Calcium fluoride Calcium phosphates Casein Crossovers Data processing Dental caries Dental enamel Dentifrices Dentistry Enamel Fluoride treatments Fluorides Lesions Microradiography Phosphate Remineralization Slurries Sodium Sodium fluoride Spectrophotometry Toothpaste Toothpastes |
| title | Importance of bioavailable calcium in fluoride dentifrices for enamel remineralization |
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