Early Anti-Oxidative and Anti-Proliferative Curcumin Effects on Neuroglioma Cells Suggest Therapeutic Targets
Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 μM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significant...
Gespeichert in:
| Veröffentlicht in: | Neurochemical research 2008-09, Vol.33 (9), p.1701-1710 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1710 |
|---|---|
| container_issue | 9 |
| container_start_page | 1701 |
| container_title | Neurochemical research |
| container_volume | 33 |
| creator | Panchal, Heena D. Vranizan, Karen Lee, Chun Y. Ho, Jacqueline Ngai, John Timiras, Paola S. |
| description | Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 μM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates gene expression in four primary pathways: oxidative stress, cell cycle control, and DNA transcription and metabolism. Contribution of the pentose phosphate pathway to the pool of NADH upregulates glutathione and activates aldehyde oxidase. We have identified also several new genes, up- or downregulated by curcumin, namely, aldo-keto reductase, glucose-6-phosphate dehydrogenase, and aldehyde oxidase that protect against oxidative stress. The identification of several new cell cycle control genes, including the apoptosis-related protein (pirin) and insulin-like growth factor (IGF), and of the neurofilament M protein involved in neurogenesis suggests that curcumin may have applicability in the treatment of a spectrum of neurodegenerative diseases. |
| doi_str_mv | 10.1007/s11064-008-9608-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20879435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1521795921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-d23826c0abe6a4e54811d711517af077d9431214d45162816dd60ff7e09cb9333</originalsourceid><addsrcrecordid>eNp1kV9r2zAUxcVYWdNuH2AvQ-yhb17vlWzLegwh3QqlLTR7Fooleyr-k0lWSb59FRwIDPYiwb2_c3TQIeQrwg8EELcBEco8A6gyWaZj_4EssBA8KyXwj2QBPG05SrgkVyG8AiQVw0_kEismpaxgQfq19t2BLofJZU97Z_Tk3izVg5lHz37sXGP9PF5FX8feDXTdNLaeAh0H-mijH9vOjb2mK9t1gb7EtrVhops_SbezcXI13Wjf2il8JheN7oL9crqvye-79Wb1K3t4-nm_Wj5kdQ4wZYbxipU16K0tdW6LvEI0ArFAoRsQwsicI8Pc5AWWrMLSmBKaRliQ9VZyzq_Jzey78-PfmMKo3oU6pdODHWNQDCqRPIoEfv8HfB2jH1I2xRiKKpcCE4QzVPsxBG8btfOu1_6gENSxCDUXoVIR6liE2ifNt5Nx3PbWnBWnn08Am4GQVkNr_fnl_7u-A7Qnk5M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221784971</pqid></control><display><type>article</type><title>Early Anti-Oxidative and Anti-Proliferative Curcumin Effects on Neuroglioma Cells Suggest Therapeutic Targets</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Panchal, Heena D. ; Vranizan, Karen ; Lee, Chun Y. ; Ho, Jacqueline ; Ngai, John ; Timiras, Paola S.</creator><creatorcontrib>Panchal, Heena D. ; Vranizan, Karen ; Lee, Chun Y. ; Ho, Jacqueline ; Ngai, John ; Timiras, Paola S.</creatorcontrib><description>Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 μM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates gene expression in four primary pathways: oxidative stress, cell cycle control, and DNA transcription and metabolism. Contribution of the pentose phosphate pathway to the pool of NADH upregulates glutathione and activates aldehyde oxidase. We have identified also several new genes, up- or downregulated by curcumin, namely, aldo-keto reductase, glucose-6-phosphate dehydrogenase, and aldehyde oxidase that protect against oxidative stress. The identification of several new cell cycle control genes, including the apoptosis-related protein (pirin) and insulin-like growth factor (IGF), and of the neurofilament M protein involved in neurogenesis suggests that curcumin may have applicability in the treatment of a spectrum of neurodegenerative diseases.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-008-9608-x</identifier><identifier>PMID: 18299980</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cluster Analysis ; Curcuma longa ; Curcumin - pharmacology ; Curcumin - therapeutic use ; Gene Expression Profiling ; Gene Expression Regulation - drug effects ; Glioma - drug therapy ; Glioma - metabolism ; Neurochemistry ; Neurology ; Neurosciences ; Oligodendroglia - drug effects ; Oligodendroglia - physiology ; Oligonucleotide Array Sequence Analysis ; Original Paper ; Rats</subject><ispartof>Neurochemical research, 2008-09, Vol.33 (9), p.1701-1710</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-d23826c0abe6a4e54811d711517af077d9431214d45162816dd60ff7e09cb9333</citedby><cites>FETCH-LOGICAL-c400t-d23826c0abe6a4e54811d711517af077d9431214d45162816dd60ff7e09cb9333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-008-9608-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-008-9608-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18299980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panchal, Heena D.</creatorcontrib><creatorcontrib>Vranizan, Karen</creatorcontrib><creatorcontrib>Lee, Chun Y.</creatorcontrib><creatorcontrib>Ho, Jacqueline</creatorcontrib><creatorcontrib>Ngai, John</creatorcontrib><creatorcontrib>Timiras, Paola S.</creatorcontrib><title>Early Anti-Oxidative and Anti-Proliferative Curcumin Effects on Neuroglioma Cells Suggest Therapeutic Targets</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 μM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates gene expression in four primary pathways: oxidative stress, cell cycle control, and DNA transcription and metabolism. Contribution of the pentose phosphate pathway to the pool of NADH upregulates glutathione and activates aldehyde oxidase. We have identified also several new genes, up- or downregulated by curcumin, namely, aldo-keto reductase, glucose-6-phosphate dehydrogenase, and aldehyde oxidase that protect against oxidative stress. The identification of several new cell cycle control genes, including the apoptosis-related protein (pirin) and insulin-like growth factor (IGF), and of the neurofilament M protein involved in neurogenesis suggests that curcumin may have applicability in the treatment of a spectrum of neurodegenerative diseases.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cluster Analysis</subject><subject>Curcuma longa</subject><subject>Curcumin - pharmacology</subject><subject>Curcumin - therapeutic use</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glioma - drug therapy</subject><subject>Glioma - metabolism</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Oligodendroglia - drug effects</subject><subject>Oligodendroglia - physiology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Original Paper</subject><subject>Rats</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kV9r2zAUxcVYWdNuH2AvQ-yhb17vlWzLegwh3QqlLTR7Fooleyr-k0lWSb59FRwIDPYiwb2_c3TQIeQrwg8EELcBEco8A6gyWaZj_4EssBA8KyXwj2QBPG05SrgkVyG8AiQVw0_kEismpaxgQfq19t2BLofJZU97Z_Tk3izVg5lHz37sXGP9PF5FX8feDXTdNLaeAh0H-mijH9vOjb2mK9t1gb7EtrVhops_SbezcXI13Wjf2il8JheN7oL9crqvye-79Wb1K3t4-nm_Wj5kdQ4wZYbxipU16K0tdW6LvEI0ArFAoRsQwsicI8Pc5AWWrMLSmBKaRliQ9VZyzq_Jzey78-PfmMKo3oU6pdODHWNQDCqRPIoEfv8HfB2jH1I2xRiKKpcCE4QzVPsxBG8btfOu1_6gENSxCDUXoVIR6liE2ifNt5Nx3PbWnBWnn08Am4GQVkNr_fnl_7u-A7Qnk5M</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Panchal, Heena D.</creator><creator>Vranizan, Karen</creator><creator>Lee, Chun Y.</creator><creator>Ho, Jacqueline</creator><creator>Ngai, John</creator><creator>Timiras, Paola S.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20080901</creationdate><title>Early Anti-Oxidative and Anti-Proliferative Curcumin Effects on Neuroglioma Cells Suggest Therapeutic Targets</title><author>Panchal, Heena D. ; Vranizan, Karen ; Lee, Chun Y. ; Ho, Jacqueline ; Ngai, John ; Timiras, Paola S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-d23826c0abe6a4e54811d711517af077d9431214d45162816dd60ff7e09cb9333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cluster Analysis</topic><topic>Curcuma longa</topic><topic>Curcumin - pharmacology</topic><topic>Curcumin - therapeutic use</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glioma - drug therapy</topic><topic>Glioma - metabolism</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Oligodendroglia - drug effects</topic><topic>Oligodendroglia - physiology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Original Paper</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panchal, Heena D.</creatorcontrib><creatorcontrib>Vranizan, Karen</creatorcontrib><creatorcontrib>Lee, Chun Y.</creatorcontrib><creatorcontrib>Ho, Jacqueline</creatorcontrib><creatorcontrib>Ngai, John</creatorcontrib><creatorcontrib>Timiras, Paola S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panchal, Heena D.</au><au>Vranizan, Karen</au><au>Lee, Chun Y.</au><au>Ho, Jacqueline</au><au>Ngai, John</au><au>Timiras, Paola S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Anti-Oxidative and Anti-Proliferative Curcumin Effects on Neuroglioma Cells Suggest Therapeutic Targets</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>33</volume><issue>9</issue><spage>1701</spage><epage>1710</epage><pages>1701-1710</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 μM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates gene expression in four primary pathways: oxidative stress, cell cycle control, and DNA transcription and metabolism. Contribution of the pentose phosphate pathway to the pool of NADH upregulates glutathione and activates aldehyde oxidase. We have identified also several new genes, up- or downregulated by curcumin, namely, aldo-keto reductase, glucose-6-phosphate dehydrogenase, and aldehyde oxidase that protect against oxidative stress. The identification of several new cell cycle control genes, including the apoptosis-related protein (pirin) and insulin-like growth factor (IGF), and of the neurofilament M protein involved in neurogenesis suggests that curcumin may have applicability in the treatment of a spectrum of neurodegenerative diseases.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18299980</pmid><doi>10.1007/s11064-008-9608-x</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 2008-09, Vol.33 (9), p.1701-1710 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20879435 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Antioxidants - pharmacology Antioxidants - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Line, Tumor Cell Proliferation - drug effects Cluster Analysis Curcuma longa Curcumin - pharmacology Curcumin - therapeutic use Gene Expression Profiling Gene Expression Regulation - drug effects Glioma - drug therapy Glioma - metabolism Neurochemistry Neurology Neurosciences Oligodendroglia - drug effects Oligodendroglia - physiology Oligonucleotide Array Sequence Analysis Original Paper Rats |
| title | Early Anti-Oxidative and Anti-Proliferative Curcumin Effects on Neuroglioma Cells Suggest Therapeutic Targets |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T06%3A23%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20Anti-Oxidative%20and%20Anti-Proliferative%20Curcumin%20Effects%20on%20Neuroglioma%20Cells%20Suggest%20Therapeutic%20Targets&rft.jtitle=Neurochemical%20research&rft.au=Panchal,%20Heena%20D.&rft.date=2008-09-01&rft.volume=33&rft.issue=9&rft.spage=1701&rft.epage=1710&rft.pages=1701-1710&rft.issn=0364-3190&rft.eissn=1573-6903&rft_id=info:doi/10.1007/s11064-008-9608-x&rft_dat=%3Cproquest_cross%3E1521795921%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=221784971&rft_id=info:pmid/18299980&rfr_iscdi=true |