Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers
Abstract Introduction Nuclear medicine workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We use...
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| Veröffentlicht in: | Nuclear medicine and biology 2009-07, Vol.36 (5), p.575-578 |
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| creator | Sahin, Ali Tatar, Abdulgani Oztas, Sıtkı Seven, Bedri Varoglu, Erhan Yesilyurt, Ahmet Ayan, Arif Kursad |
| description | Abstract Introduction Nuclear medicine workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We used two different indicators of genotoxicity methods: sister chromatid exchange (SCE) and micronucleus (MN). Methods The present research was carried out using 21 nuclear medicine workers (11 females and 10 males) during two periods: during normal working conditions and after a 1-month vacation. The radiation dose varied from 1.20 to 48.56 mSv, which accumulated during the occupational exposure time between two vacations. Peripheral blood samples were taken from each subject for two distinct lymphocyte cultures (SCE and MN) in each period. Results In nearly all subjects, SCE values increased significantly during radiation exposure compared to the postvacation period ( P |
| doi_str_mv | 10.1016/j.nucmedbio.2009.02.003 |
| format | Article |
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It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We used two different indicators of genotoxicity methods: sister chromatid exchange (SCE) and micronucleus (MN). Methods The present research was carried out using 21 nuclear medicine workers (11 females and 10 males) during two periods: during normal working conditions and after a 1-month vacation. The radiation dose varied from 1.20 to 48.56 mSv, which accumulated during the occupational exposure time between two vacations. Peripheral blood samples were taken from each subject for two distinct lymphocyte cultures (SCE and MN) in each period. Results In nearly all subjects, SCE values increased significantly during radiation exposure compared to the postvacation period ( P <.05). Similarly, MN frequencies in most of the subjects increased significantly during radiation exposure compared to the postvacation period ( P <.05). Conclusions This study revealed that both SCE and MN frequencies in most of the subjects were significantly higher during exposure to ionizing radiation than after a 1-month vacation period. However, this genotoxic effect was reversible in most of the subjects.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/j.nucmedbio.2009.02.003</identifier><identifier>PMID: 19520299</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Animals ; Holidays ; Humans ; Ionizing radiation ; Lymphocytes - radiation effects ; Male ; Micronucleus ; Micronucleus Tests ; Mutagenicity Tests ; Nuclear Medicine - manpower ; Occupational Exposure - adverse effects ; Radiation Dosage ; Radiology ; Sister chromatid exchange ; Sister Chromatid Exchange - radiation effects ; Time Factors</subject><ispartof>Nuclear medicine and biology, 2009-07, Vol.36 (5), p.575-578</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-b43e94e806c74a7751878fd289be384b27c479fd91e621de5b5af5838350e87d3</citedby><cites>FETCH-LOGICAL-c455t-b43e94e806c74a7751878fd289be384b27c479fd91e621de5b5af5838350e87d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0969805109000778$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19520299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Ali</creatorcontrib><creatorcontrib>Tatar, Abdulgani</creatorcontrib><creatorcontrib>Oztas, Sıtkı</creatorcontrib><creatorcontrib>Seven, Bedri</creatorcontrib><creatorcontrib>Varoglu, Erhan</creatorcontrib><creatorcontrib>Yesilyurt, Ahmet</creatorcontrib><creatorcontrib>Ayan, Arif Kursad</creatorcontrib><title>Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>Abstract Introduction Nuclear medicine workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We used two different indicators of genotoxicity methods: sister chromatid exchange (SCE) and micronucleus (MN). Methods The present research was carried out using 21 nuclear medicine workers (11 females and 10 males) during two periods: during normal working conditions and after a 1-month vacation. The radiation dose varied from 1.20 to 48.56 mSv, which accumulated during the occupational exposure time between two vacations. Peripheral blood samples were taken from each subject for two distinct lymphocyte cultures (SCE and MN) in each period. Results In nearly all subjects, SCE values increased significantly during radiation exposure compared to the postvacation period ( P <.05). Similarly, MN frequencies in most of the subjects increased significantly during radiation exposure compared to the postvacation period ( P <.05). Conclusions This study revealed that both SCE and MN frequencies in most of the subjects were significantly higher during exposure to ionizing radiation than after a 1-month vacation period. However, this genotoxic effect was reversible in most of the subjects.</description><subject>Adult</subject><subject>Animals</subject><subject>Holidays</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Lymphocytes - radiation effects</subject><subject>Male</subject><subject>Micronucleus</subject><subject>Micronucleus Tests</subject><subject>Mutagenicity Tests</subject><subject>Nuclear Medicine - manpower</subject><subject>Occupational Exposure - adverse effects</subject><subject>Radiation Dosage</subject><subject>Radiology</subject><subject>Sister chromatid exchange</subject><subject>Sister Chromatid Exchange - radiation effects</subject><subject>Time Factors</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCXwCfuCWMnTi2L0hV1UKlShyAs-U4k9bbrL3YST_49TjaFUicOHnked_5eIaQ9wxqBqz7uK3D4nY49D7WHEDXwGuA5gXZMCV5pTvWviQb0J2uFAh2Qk5z3kJxtgxekxOmBQeu9YbEywc7LXb2MdA40vkO6S2GOMcn7yiOI7o5rwl3l2IoX1N8rIaYkRaD_-XDLU128Ac_Pu1jXhLSEpfxJrSJlhm98wHpY0z3mPIb8mq0U8a3x_eM_Li6_H7xpbr5-vn64vymcq0Qc9W3DeoWFXROtlZKUdZS48CV7rFRbc-la6UeB82w42xA0Qs7CtWoRgAqOTRn5MOh7j7Fnwvm2ex8djhNNmBcsuGgZKcUK0J5ELoUc044mn3yO5ueDQOzsjZb84e1WVkb4KawLs53xxZLX9J_fUe4RXB-EGBZ9MFjMtl5DK4gSYWrGaL_jyaf_qnhJl8OYad7fMa8jUsKhaNhJheD-baefL04aACQUjW_AcRvqy4</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Sahin, Ali</creator><creator>Tatar, Abdulgani</creator><creator>Oztas, Sıtkı</creator><creator>Seven, Bedri</creator><creator>Varoglu, Erhan</creator><creator>Yesilyurt, Ahmet</creator><creator>Ayan, Arif Kursad</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20090701</creationdate><title>Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers</title><author>Sahin, Ali ; Tatar, Abdulgani ; Oztas, Sıtkı ; Seven, Bedri ; Varoglu, Erhan ; Yesilyurt, Ahmet ; Ayan, Arif Kursad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-b43e94e806c74a7751878fd289be384b27c479fd91e621de5b5af5838350e87d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Holidays</topic><topic>Humans</topic><topic>Ionizing radiation</topic><topic>Lymphocytes - radiation effects</topic><topic>Male</topic><topic>Micronucleus</topic><topic>Micronucleus Tests</topic><topic>Mutagenicity Tests</topic><topic>Nuclear Medicine - manpower</topic><topic>Occupational Exposure - adverse effects</topic><topic>Radiation Dosage</topic><topic>Radiology</topic><topic>Sister chromatid exchange</topic><topic>Sister Chromatid Exchange - radiation effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Ali</creatorcontrib><creatorcontrib>Tatar, Abdulgani</creatorcontrib><creatorcontrib>Oztas, Sıtkı</creatorcontrib><creatorcontrib>Seven, Bedri</creatorcontrib><creatorcontrib>Varoglu, Erhan</creatorcontrib><creatorcontrib>Yesilyurt, Ahmet</creatorcontrib><creatorcontrib>Ayan, Arif Kursad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Ali</au><au>Tatar, Abdulgani</au><au>Oztas, Sıtkı</au><au>Seven, Bedri</au><au>Varoglu, Erhan</au><au>Yesilyurt, Ahmet</au><au>Ayan, Arif Kursad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>36</volume><issue>5</issue><spage>575</spage><epage>578</epage><pages>575-578</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>Abstract Introduction Nuclear medicine workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We used two different indicators of genotoxicity methods: sister chromatid exchange (SCE) and micronucleus (MN). Methods The present research was carried out using 21 nuclear medicine workers (11 females and 10 males) during two periods: during normal working conditions and after a 1-month vacation. The radiation dose varied from 1.20 to 48.56 mSv, which accumulated during the occupational exposure time between two vacations. Peripheral blood samples were taken from each subject for two distinct lymphocyte cultures (SCE and MN) in each period. Results In nearly all subjects, SCE values increased significantly during radiation exposure compared to the postvacation period ( P <.05). Similarly, MN frequencies in most of the subjects increased significantly during radiation exposure compared to the postvacation period ( P <.05). Conclusions This study revealed that both SCE and MN frequencies in most of the subjects were significantly higher during exposure to ionizing radiation than after a 1-month vacation period. However, this genotoxic effect was reversible in most of the subjects.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19520299</pmid><doi>10.1016/j.nucmedbio.2009.02.003</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Animals Holidays Humans Ionizing radiation Lymphocytes - radiation effects Male Micronucleus Micronucleus Tests Mutagenicity Tests Nuclear Medicine - manpower Occupational Exposure - adverse effects Radiation Dosage Radiology Sister chromatid exchange Sister Chromatid Exchange - radiation effects Time Factors |
| title | Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers |
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