Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7receptor-mediated IL-1 beta release

We investigated the consequences of transient application of specific stimuli mimicking inflammation to hippocampal tissue on microglia activation and neuronal cell vulnerability to a subsequent excitotoxic insult. Two-week-old organotypic hippocampal slice cultures, from 7-day-old C57BL/6 donor mic...

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Veröffentlicht in:	Journal of neurochemistry 2008-07, Vol.106 (1), p.271-280
Hauptverfasser:	Bernardino, Liliana, Balosso, Silvia, Ravizza, Teresa, Marchi, Nicola, Ku, George, Randle, John C, Malva, Joao O, Vezzani, Annamaria
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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