Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity

New series of 5-(morpholinosulfonyl) isatin derivatives were designed and synthesized. The new compounds were characterized on the basis of spectral and elemental analyses. They were examined for their cytotoxic effects using SRB assay on four cancer cell lines HepG2, HCT116, CACO and MCF-7 in addit...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of medicinal chemistry 2018-08, Vol.156, p.918-932
Hauptverfasser:	Ammar, Yousry A., Sh El-Sharief, Ahmed M., Belal, Amany, Abbas, Samir Y., Mohamed, Yehia A., Mehany, Ahmed B.M., Ragab, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-cancer activity Cytotoxicity EGFR tyrosine kinase Hydrazones Isatin Morpholin Schiff's bases Sulfonamides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!