A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, INU-101

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a cortisol regenerating enzyme that amplifies tissue glucocorticoid levels, especially in the liver and adipose tissue. Knockout mice or a selective inhibitor of 11β-HSD1 improves metabolic syndrome parameters in preclinical models and human clin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2018-09, Vol.835, p.169-178
Hauptverfasser:	Hong, Sung Pyo, Han, Dongoh, Chang, Ki-Ho, Ahn, Soon Kil
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors 11-beta-Hydroxysteroid Dehydrogenase Type 1 - chemistry 11β-HSD1 inhibitor 3T3-L1 Cells Adamantane - analogs & derivatives Adamantane - chemistry Adamantane - pharmacokinetics Adamantane - pharmacology Animals Body Weight - drug effects Enzyme Inhibitors - pharmacology Glucocorticoid Humans Metabolic syndrome Mice Models, Molecular Obesity Protein Conformation Rats Type II diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!