An in-depth view of potential dual effect of thymol in inhibiting xanthine oxidase activity: Electrochemical measurements in combination with four way PARAFAC analysis and molecular docking insights

Xanthine oxidase (XO) can catalyze xanthine to uric acid and has also been linked with the extension of some serious diseases such as cancer, gout, diabetes and so on. Thymol is a part of diet in the form of spices. Due to the high antioxidant activity, its inhibitory effect on XO was studied in the...

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Veröffentlicht in:	International journal of biological macromolecules 2018-11, Vol.119, p.1298-1310
Hauptverfasser:	Abbasi, Saleheh, Gharaghani, Sajjad, Benvidi, Ali, Rezaeinasab, Masoud, Saboury, Ali Akbar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Cattle Docking studies Electrochemical mechanism Electrochemistry Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Four-way PARAFAC analysis Molecular Docking Simulation Oxidation-Reduction Protein Conformation Structure-Activity Relationship Surface Properties Thymol Thymol - chemistry Thymol - metabolism Thymol - pharmacology Xanthine - metabolism Xanthine oxidase Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - chemistry Xanthine Oxidase - metabolism
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