Biopolymers: Applications in wound healing and skin tissue engineering
Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practice...
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| Veröffentlicht in: | Molecular biology reports 2018-12, Vol.45 (6), p.2857-2867 |
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| creator | Sahana, T. G. Rekha, P. D. |
| description | Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practices, the bioactive polymers are gaining increased importance in wound care. Biopolymers are naturally occurring biomolecules synthesized by microbes, plants and animals with highest degree of biocompatibility. The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process. The versatile properties of the biopolymers such as cellulose, alginate, hyaluronic acid, collagen, chitosan etc have been exploited in the current wound care market. With the technological advances in material science, regenerative medicine, nanotechnology, and bioengineering; the functional and structural characteristics of biopolymers can be improved to suit the current wound care demands such as tissue repair, restoration of lost tissue integrity and scarless healing. In this review we highlight on the sources, mechanism of action and bioengineering approaches adapted for commercial exploitation. |
| doi_str_mv | 10.1007/s11033-018-4296-3 |
| format | Article |
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G. ; Rekha, P. D.</creator><creatorcontrib>Sahana, T. G. ; Rekha, P. D.</creatorcontrib><description>Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practices, the bioactive polymers are gaining increased importance in wound care. Biopolymers are naturally occurring biomolecules synthesized by microbes, plants and animals with highest degree of biocompatibility. The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process. The versatile properties of the biopolymers such as cellulose, alginate, hyaluronic acid, collagen, chitosan etc have been exploited in the current wound care market. With the technological advances in material science, regenerative medicine, nanotechnology, and bioengineering; the functional and structural characteristics of biopolymers can be improved to suit the current wound care demands such as tissue repair, restoration of lost tissue integrity and scarless healing. 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D.</creatorcontrib><title>Biopolymers: Applications in wound healing and skin tissue engineering</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practices, the bioactive polymers are gaining increased importance in wound care. Biopolymers are naturally occurring biomolecules synthesized by microbes, plants and animals with highest degree of biocompatibility. The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process. The versatile properties of the biopolymers such as cellulose, alginate, hyaluronic acid, collagen, chitosan etc have been exploited in the current wound care market. With the technological advances in material science, regenerative medicine, nanotechnology, and bioengineering; the functional and structural characteristics of biopolymers can be improved to suit the current wound care demands such as tissue repair, restoration of lost tissue integrity and scarless healing. 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The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process. The versatile properties of the biopolymers such as cellulose, alginate, hyaluronic acid, collagen, chitosan etc have been exploited in the current wound care market. With the technological advances in material science, regenerative medicine, nanotechnology, and bioengineering; the functional and structural characteristics of biopolymers can be improved to suit the current wound care demands such as tissue repair, restoration of lost tissue integrity and scarless healing. In this review we highlight on the sources, mechanism of action and bioengineering approaches adapted for commercial exploitation.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30094529</pmid><doi>10.1007/s11033-018-4296-3</doi><tpages>11</tpages></addata></record> |
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| subjects | Alginates - therapeutic use Alginic acid Angiogenesis Animal Anatomy Animal Biochemistry Animals Biocompatibility Bioengineering Biomedical and Life Sciences Biopolymers Biopolymers - therapeutic use Cellulose Cellulose - therapeutic use Chitosan Chitosan - therapeutic use Collagen Collagen - therapeutic use Diabetes mellitus Histology Humans Hyaluronic acid Hyaluronic Acid - therapeutic use Immunomodulation Life Sciences Morphology Regenerative medicine Regenerative Medicine - methods Review Skin Skin - metabolism Skin Transplantation - methods Structure-function relationships Tissue engineering Tissue Engineering - methods Wound healing Wound Healing - drug effects |
| title | Biopolymers: Applications in wound healing and skin tissue engineering |
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