Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study
Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities.In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a...
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| Veröffentlicht in: | The European respiratory journal 2018-10, Vol.52 (4), p.1701972 |
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| creator | Mônico-Neto, Marcos Moreira Antunes, Hanna Karen Dos Santos, Ronaldo Vagner Thomatieli D'Almeida, Vânia Alves Lino de Souza, Altay Azeredo Bittencourt, Lia Rita Tufik, Sergio |
| description | Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities.In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the incidence of cardiometabolic diseases, in an 8-9-year follow-up study. We analysed data of 658 volunteers from the São Paulo Epidemiologic Sleep Study (EPISONO), a cohort study of individuals aged 20-80 years, collected through polysomnography, the International Physical Activity Questionnaire and an assessment of cardiometabolic profile.Active subjects had a lower risk of developing OSA compared with nonactive subjects (relative risk 0.877, 95% CI 0.296-0.855) and there was a reduced risk of developing type 2 diabetes mellitus in active/apnoeic subjects (relative risk 0.493, 95% CI 0.252-0.961) compared with nonactive subjects. Metabolic equivalent was negatively associated to cardiometabolic markers, such as C-reactive protein (exp(
)=0.720; p=0.001), interleukin-6 (exp(
)=0.991; p=0.03), insulin (exp(
)=0.982; p=0.03), triglycerides (exp(
)=0.997; p |
| doi_str_mv | 10.1183/13993003.01972-2017 |
| format | Article |
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)=0.720; p=0.001), interleukin-6 (exp(
)=0.991; p=0.03), insulin (exp(
)=0.982; p=0.03), triglycerides (exp(
)=0.997; p<0.001), homeostasis model assessment for insulin resistance (exp(
)≤0.946; p<0.024), quantitative insulin sensitivity check index (exp(
)=992.4; p<0.001) and mean arterial pressure (exp(
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)=0.720; p=0.001), interleukin-6 (exp(
)=0.991; p=0.03), insulin (exp(
)=0.982; p=0.03), triglycerides (exp(
)=0.997; p<0.001), homeostasis model assessment for insulin resistance (exp(
)≤0.946; p<0.024), quantitative insulin sensitivity check index (exp(
)=992.4; p<0.001) and mean arterial pressure (exp(
)=0.987; p=0.001).Physical activity was a protective factor against type 2 diabetes mellitus in apnoeic individuals; moreover, being active reduced the risk of developing OSA and was associated with a better cardiometabolic profile.</description><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNo9kElrwzAQhUVpadLlFxSKjr041RLZ0rGELoHQFJq7GctjqsaOUkku5N_X7nYYZnjz3gx8hFxxNuNcy1sujZGMyRnjphCZYLw4ItNRzUb5mEyZYTLjRuYTchbjO2M8n0t-SibD3khViCnZvrwdorPQUrDJfbp0oBAp0M7XGCD5QJuhfBVT6EcD0tgi7insdx6Bwq6mFkLtfIcJKt86S4OLW-p2NL0hvX9Zvq6f1zSmvj5ckJMG2oiXv_2cbB7uN4unbLV-XC7uVpmViqVMVKaxMM8bpVQFqBsGwIVgYo6FLoYJdaWVlZjzAhUYLuY2x4I3DRqWM3lObn7O7oP_6DGmsnPRYtvCDn0fS8F0obTWQg1W-WO1wccYsCn3wXUQDiVn5Qi5_INcfkMuR8hD6vr3QV91WP9n_qjKL92qd64</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Mônico-Neto, Marcos</creator><creator>Moreira Antunes, Hanna Karen</creator><creator>Dos Santos, Ronaldo Vagner Thomatieli</creator><creator>D'Almeida, Vânia</creator><creator>Alves Lino de Souza, Altay</creator><creator>Azeredo Bittencourt, Lia Rita</creator><creator>Tufik, Sergio</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study</title><author>Mônico-Neto, Marcos ; Moreira Antunes, Hanna Karen ; Dos Santos, Ronaldo Vagner Thomatieli ; D'Almeida, Vânia ; Alves Lino de Souza, Altay ; Azeredo Bittencourt, Lia Rita ; Tufik, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-2b9fca46f555bae8f0aa122024e787122e8b85c3e617e5a9124c6e71ffe90603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mônico-Neto, Marcos</creatorcontrib><creatorcontrib>Moreira Antunes, Hanna Karen</creatorcontrib><creatorcontrib>Dos Santos, Ronaldo Vagner Thomatieli</creatorcontrib><creatorcontrib>D'Almeida, Vânia</creatorcontrib><creatorcontrib>Alves Lino de Souza, Altay</creatorcontrib><creatorcontrib>Azeredo Bittencourt, Lia Rita</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mônico-Neto, Marcos</au><au>Moreira Antunes, Hanna Karen</au><au>Dos Santos, Ronaldo Vagner Thomatieli</au><au>D'Almeida, Vânia</au><au>Alves Lino de Souza, Altay</au><au>Azeredo Bittencourt, Lia Rita</au><au>Tufik, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2018-10</date><risdate>2018</risdate><volume>52</volume><issue>4</issue><spage>1701972</spage><pages>1701972-</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities.In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the incidence of cardiometabolic diseases, in an 8-9-year follow-up study. We analysed data of 658 volunteers from the São Paulo Epidemiologic Sleep Study (EPISONO), a cohort study of individuals aged 20-80 years, collected through polysomnography, the International Physical Activity Questionnaire and an assessment of cardiometabolic profile.Active subjects had a lower risk of developing OSA compared with nonactive subjects (relative risk 0.877, 95% CI 0.296-0.855) and there was a reduced risk of developing type 2 diabetes mellitus in active/apnoeic subjects (relative risk 0.493, 95% CI 0.252-0.961) compared with nonactive subjects. Metabolic equivalent was negatively associated to cardiometabolic markers, such as C-reactive protein (exp(
)=0.720; p=0.001), interleukin-6 (exp(
)=0.991; p=0.03), insulin (exp(
)=0.982; p=0.03), triglycerides (exp(
)=0.997; p<0.001), homeostasis model assessment for insulin resistance (exp(
)≤0.946; p<0.024), quantitative insulin sensitivity check index (exp(
)=992.4; p<0.001) and mean arterial pressure (exp(
)=0.987; p=0.001).Physical activity was a protective factor against type 2 diabetes mellitus in apnoeic individuals; moreover, being active reduced the risk of developing OSA and was associated with a better cardiometabolic profile.</abstract><cop>England</cop><pmid>30093572</pmid><doi>10.1183/13993003.01972-2017</doi><oa>free_for_read</oa></addata></record> |
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| title | Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study |
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