A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism

•A mathematical model of brain-centered glucoregulatory system is proposed.•Effects of leptin on hyperglycemia are quantified.•Leptin administration drastically improves insulin therapy. Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glu...

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Veröffentlicht in:	Journal of theoretical biology 2018-11, Vol.456, p.213-223
Hauptverfasser:	Kadota, Rei, Sugita, Kazuma, Uchida, Kenko, Yamada, Hitoshi, Yamashita, Masashi, Kimura, Hidenori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Brain - metabolism Brain-centered glucoregulatory system Computer Simulation Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Endogenous glucose production Glucose Tolerance Test Humans Hypoglycemia Hypoglycemic Agents - therapeutic use Insulin Insulin sensitivity Leptin - physiology Leptin - therapeutic use Models, Biological
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