A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism
•A mathematical model of brain-centered glucoregulatory system is proposed.•Effects of leptin on hyperglycemia are quantified.•Leptin administration drastically improves insulin therapy. Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glu...
Gespeichert in:
| Veröffentlicht in: | Journal of theoretical biology 2018-11, Vol.456, p.213-223 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 223 |
|---|---|
| container_issue | |
| container_start_page | 213 |
| container_title | Journal of theoretical biology |
| container_volume | 456 |
| creator | Kadota, Rei Sugita, Kazuma Uchida, Kenko Yamada, Hitoshi Yamashita, Masashi Kimura, Hidenori |
| description | •A mathematical model of brain-centered glucoregulatory system is proposed.•Effects of leptin on hyperglycemia are quantified.•Leptin administration drastically improves insulin therapy.
Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. There are growing expectations that leptin can improve the current insulin treatment for patients with type 1 diabetes. We investigated this possibility through in silico experiments based on a mathematical model of diabetes, which is currently the only mode of research that eliminates human risk. A model of the brain-centered glucoregulatory system, in which leptin plays a central role, was constructed and integrated within a conventional model of insulin/glucose dynamics. The model has been validated using experimental data from animal studies. The in silico combination experiments showed excellent therapeutic performance over insulin monotherapy. |
| doi_str_mv | 10.1016/j.jtbi.2018.08.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2087588629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022519318303813</els_id><sourcerecordid>2087588629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-2f9c4889e02df6e4e22982f7b88c1e655501db83afe425fa6bcb1c7def1b37a03</originalsourceid><addsrcrecordid>eNp9kEFrGzEQhUVJqR23fyCHoGMu64y0q7UWcjEhbQOGXNpehaQduTLalbuSDf73lbHbY-AxM4f3HsxHyB2DJQPWPu6Wu2z8kgOTSygC-YHMGXSikqJhN2QOwHklWFfPyG1KOwDomrr9RGZ1uWTNYU5-remg828sw1sd6BB7DDQ6mk97pIz2XhvMmKgfjzEc_bilAffZjxSdQ5sTjSPdhoONCemAWZsYfBo-k49Oh4RfrntBfn59-fH8vdq8fXt9Xm8qW4s2V9x1tpGyQ-C9a7FBzjvJ3cpIaRm2QghgvZG1dthw4XRrrGF21aNjpl5pqBfk4dK7n-KfA6asBp8shqBHjIekOMiVkLLlXbHyi9VOMaUJndpPftDTSTFQZ55qp8481ZmngiKQJXR_7T-YAfv_kX8Ai-HpYsDy5dHjpJL1OFrs_VTwqD769_r_Als5h2g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2087588629</pqid></control><display><type>article</type><title>A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kadota, Rei ; Sugita, Kazuma ; Uchida, Kenko ; Yamada, Hitoshi ; Yamashita, Masashi ; Kimura, Hidenori</creator><creatorcontrib>Kadota, Rei ; Sugita, Kazuma ; Uchida, Kenko ; Yamada, Hitoshi ; Yamashita, Masashi ; Kimura, Hidenori</creatorcontrib><description>•A mathematical model of brain-centered glucoregulatory system is proposed.•Effects of leptin on hyperglycemia are quantified.•Leptin administration drastically improves insulin therapy.
Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. There are growing expectations that leptin can improve the current insulin treatment for patients with type 1 diabetes. We investigated this possibility through in silico experiments based on a mathematical model of diabetes, which is currently the only mode of research that eliminates human risk. A model of the brain-centered glucoregulatory system, in which leptin plays a central role, was constructed and integrated within a conventional model of insulin/glucose dynamics. The model has been validated using experimental data from animal studies. The in silico combination experiments showed excellent therapeutic performance over insulin monotherapy.</description><identifier>ISSN: 0022-5193</identifier><identifier>EISSN: 1095-8541</identifier><identifier>DOI: 10.1016/j.jtbi.2018.08.008</identifier><identifier>PMID: 30098320</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Blood Glucose - metabolism ; Brain - metabolism ; Brain-centered glucoregulatory system ; Computer Simulation ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Endogenous glucose production ; Glucose Tolerance Test ; Humans ; Hypoglycemia ; Hypoglycemic Agents - therapeutic use ; Insulin ; Insulin sensitivity ; Leptin - physiology ; Leptin - therapeutic use ; Models, Biological</subject><ispartof>Journal of theoretical biology, 2018-11, Vol.456, p.213-223</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-2f9c4889e02df6e4e22982f7b88c1e655501db83afe425fa6bcb1c7def1b37a03</citedby><cites>FETCH-LOGICAL-c356t-2f9c4889e02df6e4e22982f7b88c1e655501db83afe425fa6bcb1c7def1b37a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022519318303813$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30098320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kadota, Rei</creatorcontrib><creatorcontrib>Sugita, Kazuma</creatorcontrib><creatorcontrib>Uchida, Kenko</creatorcontrib><creatorcontrib>Yamada, Hitoshi</creatorcontrib><creatorcontrib>Yamashita, Masashi</creatorcontrib><creatorcontrib>Kimura, Hidenori</creatorcontrib><title>A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism</title><title>Journal of theoretical biology</title><addtitle>J Theor Biol</addtitle><description>•A mathematical model of brain-centered glucoregulatory system is proposed.•Effects of leptin on hyperglycemia are quantified.•Leptin administration drastically improves insulin therapy.
Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. There are growing expectations that leptin can improve the current insulin treatment for patients with type 1 diabetes. We investigated this possibility through in silico experiments based on a mathematical model of diabetes, which is currently the only mode of research that eliminates human risk. A model of the brain-centered glucoregulatory system, in which leptin plays a central role, was constructed and integrated within a conventional model of insulin/glucose dynamics. The model has been validated using experimental data from animal studies. The in silico combination experiments showed excellent therapeutic performance over insulin monotherapy.</description><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Brain - metabolism</subject><subject>Brain-centered glucoregulatory system</subject><subject>Computer Simulation</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Endogenous glucose production</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin</subject><subject>Insulin sensitivity</subject><subject>Leptin - physiology</subject><subject>Leptin - therapeutic use</subject><subject>Models, Biological</subject><issn>0022-5193</issn><issn>1095-8541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrGzEQhUVJqR23fyCHoGMu64y0q7UWcjEhbQOGXNpehaQduTLalbuSDf73lbHbY-AxM4f3HsxHyB2DJQPWPu6Wu2z8kgOTSygC-YHMGXSikqJhN2QOwHklWFfPyG1KOwDomrr9RGZ1uWTNYU5-remg828sw1sd6BB7DDQ6mk97pIz2XhvMmKgfjzEc_bilAffZjxSdQ5sTjSPdhoONCemAWZsYfBo-k49Oh4RfrntBfn59-fH8vdq8fXt9Xm8qW4s2V9x1tpGyQ-C9a7FBzjvJ3cpIaRm2QghgvZG1dthw4XRrrGF21aNjpl5pqBfk4dK7n-KfA6asBp8shqBHjIekOMiVkLLlXbHyi9VOMaUJndpPftDTSTFQZ55qp8481ZmngiKQJXR_7T-YAfv_kX8Ai-HpYsDy5dHjpJL1OFrs_VTwqD769_r_Als5h2g</recordid><startdate>20181107</startdate><enddate>20181107</enddate><creator>Kadota, Rei</creator><creator>Sugita, Kazuma</creator><creator>Uchida, Kenko</creator><creator>Yamada, Hitoshi</creator><creator>Yamashita, Masashi</creator><creator>Kimura, Hidenori</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181107</creationdate><title>A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism</title><author>Kadota, Rei ; Sugita, Kazuma ; Uchida, Kenko ; Yamada, Hitoshi ; Yamashita, Masashi ; Kimura, Hidenori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-2f9c4889e02df6e4e22982f7b88c1e655501db83afe425fa6bcb1c7def1b37a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Brain - metabolism</topic><topic>Brain-centered glucoregulatory system</topic><topic>Computer Simulation</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Endogenous glucose production</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin</topic><topic>Insulin sensitivity</topic><topic>Leptin - physiology</topic><topic>Leptin - therapeutic use</topic><topic>Models, Biological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kadota, Rei</creatorcontrib><creatorcontrib>Sugita, Kazuma</creatorcontrib><creatorcontrib>Uchida, Kenko</creatorcontrib><creatorcontrib>Yamada, Hitoshi</creatorcontrib><creatorcontrib>Yamashita, Masashi</creatorcontrib><creatorcontrib>Kimura, Hidenori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of theoretical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadota, Rei</au><au>Sugita, Kazuma</au><au>Uchida, Kenko</au><au>Yamada, Hitoshi</au><au>Yamashita, Masashi</au><au>Kimura, Hidenori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism</atitle><jtitle>Journal of theoretical biology</jtitle><addtitle>J Theor Biol</addtitle><date>2018-11-07</date><risdate>2018</risdate><volume>456</volume><spage>213</spage><epage>223</epage><pages>213-223</pages><issn>0022-5193</issn><eissn>1095-8541</eissn><abstract>•A mathematical model of brain-centered glucoregulatory system is proposed.•Effects of leptin on hyperglycemia are quantified.•Leptin administration drastically improves insulin therapy.
Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. There are growing expectations that leptin can improve the current insulin treatment for patients with type 1 diabetes. We investigated this possibility through in silico experiments based on a mathematical model of diabetes, which is currently the only mode of research that eliminates human risk. A model of the brain-centered glucoregulatory system, in which leptin plays a central role, was constructed and integrated within a conventional model of insulin/glucose dynamics. The model has been validated using experimental data from animal studies. The in silico combination experiments showed excellent therapeutic performance over insulin monotherapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30098320</pmid><doi>10.1016/j.jtbi.2018.08.008</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5193 |
| ispartof | Journal of theoretical biology, 2018-11, Vol.456, p.213-223 |
| issn | 0022-5193 1095-8541 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2087588629 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Blood Glucose - metabolism Brain - metabolism Brain-centered glucoregulatory system Computer Simulation Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Endogenous glucose production Glucose Tolerance Test Humans Hypoglycemia Hypoglycemic Agents - therapeutic use Insulin Insulin sensitivity Leptin - physiology Leptin - therapeutic use Models, Biological |
| title | A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T18%3A57%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20mathematical%20model%20of%20type%201%20diabetes%20involving%20leptin%20effects%20on%20glucose%20metabolism&rft.jtitle=Journal%20of%20theoretical%20biology&rft.au=Kadota,%20Rei&rft.date=2018-11-07&rft.volume=456&rft.spage=213&rft.epage=223&rft.pages=213-223&rft.issn=0022-5193&rft.eissn=1095-8541&rft_id=info:doi/10.1016/j.jtbi.2018.08.008&rft_dat=%3Cproquest_cross%3E2087588629%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2087588629&rft_id=info:pmid/30098320&rft_els_id=S0022519318303813&rfr_iscdi=true |