Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice

Ethanolic whole plant extract of Chelidonium majus, extensively used in traditional systems of medicine against various liver ailments, has been tested for its possible anti-tumor, hepato-protective and anti-genotoxic effects in p-dimethylaminoazobenzene (p-DAB) induced hepatocarcinogenesis in mice...

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Veröffentlicht in:	Food and chemical toxicology 2008-05, Vol.46 (5), p.1474-1487
Hauptverfasser:	Biswas, S.J., Bhattacharjee, N., Khuda-Bukhsh, A.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood animal models Animals Anti-carcinogen Anti-tumor anticarcinogenic activity Anticarcinogenic Agents - pharmacology Aspartate Aminotransferases - blood Biological and medical sciences biomarkers Bone Marrow Cells - drug effects Bone Marrow Cells - ultrastructure Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Chelidonium - chemistry Chelidonium majus Chemical agents Chromosome Aberrations - drug effects Gastroenterology. Liver. Pancreas. Abdomen General pharmacology Hepatocarcinogenesis hepatoprotective effect herbal medicines histopathology kidneys Lipid Peroxidation - drug effects liver neoplasms Liver Neoplasms, Experimental - prevention & control Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences medicinal plants medicinal properties Mice Micronucleus Tests Microscopy, Electron, Scanning Microscopy, Electron, Transmission Mitotic Index oral administration p-DAB p-Dimethylaminoazobenzene - toxicity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - therapeutic use Plant poisons toxicology Sperm Head - drug effects Sperm Head - ultrastructure spleen Tissue Fixation Toxicity marker enzymes Toxicology Tumors
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