NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-[kappa]B and JNK pathways by inducing reactive oxygen species production

NOD-like receptors (NLRs) are a family of intracellular sensors of microbial- or danger-associated molecular patterns. Here, we report the identification of NLRX1, which is a new member of the NLR family that localizes to the mitochondria. NLRX1 alone failed to trigger most of the common signalling...

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Veröffentlicht in:	EMBO reports 2008-03, Vol.9 (3), p.293-300
Hauptverfasser:	Tattoli, Ivan, Carneiro, Leticia A, Jéhanno, Muguette, Magalhaes, Joao G, Shu, Youmin, Philpott, Dana J, Arnoult, Damien, Girardin, Stephen E
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular biology Immune system Oxygen Sensors Shigella Signal transduction Virology
Online-Zugang:	Volltext
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