Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme

The purified Pseudomonas aeruginosa cell wall biosynthesis MurD amide ligase enzyme was used to screen C-7-C and 12 mers peptides from phage display libraries using competitive biopanning approaches with the specific substrates d-glutamate and ATP. From the 60 phage-encoded peptides identified, DNA...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2006-07, Vol.27 (7), p.1693-1700
Hauptverfasser:	Paradis-Bleau, Catherine, Beaumont, Mélanie, Boudreault, Lydia, Lloyd, Adrian, Sanschagrin, François, Bugg, Timothy D.H., Levesque, Roger C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Binding Sites Biological and medical sciences Computational Biology - methods Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Inhibitory Concentration 50 Inhibitory peptides Ligases - antagonists & inhibitors Ligases - chemistry Models, Chemical Molecular Sequence Data MurD Peptide Library Peptides - chemistry Phage display Protein Binding Protein Conformation Pseudomonas aeruginosa Pseudomonas aeruginosa - metabolism Sequence Analysis, DNA Sequence Homology, Amino Acid Spectrophotometry UDP- N-acetylmuramyl- l-alanine: d-glutamate ligase Vertebrates: endocrinology
Online-Zugang:	Volltext
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