Synthesis and Endosomolytic Properties of Poly(amidoamine) Block Copolymers

The poly(amidoamine)s (PAAs) ISA 1 and ISA 23 display pH‐dependent conformational change and pH‐dependent membrane perturbation. These properties confer potential for use as endosomolytic polymers for intracytoplasmic delivery of toxins and genes. Both polymers are relatively non‐toxic, and moreover...

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Veröffentlicht in:	Macromolecular bioscience 2004-10, Vol.4 (10), p.922-929
Hauptverfasser:	Lavignac, Nathalie, Lazenby, Michelle, Foka, Peli, Malgesini, Beatrice, Verpilio, Ilario, Ferruti, Paolo, Duncan, Ruth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Biocompatible Materials - chemistry Biological and medical sciences block copolymers Drug Carriers - chemistry endosomotropic delivery Exact sciences and technology General pharmacology Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy Medical sciences Melanoma, Experimental Mice Models, Chemical Organic polymers pH-sensitive polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Plant Proteins - chemistry poly(amidoamine)s Polyamines - chemistry Polymers - chemistry Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts random copolymers Ribosome Inactivating Proteins, Type 1 Temperature Tetrazolium Salts - pharmacology Thiazoles - pharmacology
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