Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case–control study

Aim of this work was to assess the predictive value of micronuclei (MN) frequency in peripheral blood lymphocytes (PBL) for the risk of cancer death in disease-free individuals. Blood samples from 1650 subjects selected from the general population of Pisa, Italy, were collected between June 1991 and...

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Veröffentlicht in:	Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 2008-03, Vol.639 (1), p.27-34
Hauptverfasser:	Murgia, Elena, Ballardin, Michela, Bonassi, Stefano, Rossi, Anna Maria, Barale, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological markers Cancer risk Case-Control Studies Case–control study Cause of Death Early Diagnosis Female Follow-Up Studies Gene Frequency Humans Italy Lymphocytes - metabolism Male Micronuclei, Chromosome-Defective Micronucleus test Middle Aged Neoplasms - blood Neoplasms - diagnosis Neoplasms - genetics Neoplasms - mortality Prognosis Sensitivity and Specificity Survival Analysis Validation
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