Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation
Abstract Mucosal addressin cell adhesion molecule–1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorp...
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| Veröffentlicht in: | Human immunology 2009-06, Vol.70 (6), p.457-460 |
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| creator | Ambruzova, Zuzana Mrazek, Frantisek Raida, Ludek Stahelova, Anna Faber, Edgar Indrak, Karel Petrek, Martin |
| description | Abstract Mucosal addressin cell adhesion molecule–1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. Three MADCAM1 gene single nucleotide polymorphisms (rs758502 C/T, rs2302217 A/G, rs3745925 G/T) were genotyped by polymerase chain reaction with sequence-specific primers in 87 Czech, HLA-identical donor-recipient aHSCT pairs. MADCAM1 rs2302217 AA homozygous recipients developed chronic GVHD more frequently than patients with other genotypes ( 65% vs. 34%; p = 0.025). Furthermore, multivariate analysis revealed the MADCAM1 rs2302217 AA genotype in recipient being also an independent factor associated with development of acute GVHD ( p = 0.036) and decreased overall survival ( p = 0.001). These data suggest that MADCAM1 gene polymorphisms may be associated with the risk of chronic GVHD and may, also, affect mortality related to aHSCT. |
| doi_str_mv | 10.1016/j.humimm.2009.03.008 |
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The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. Three MADCAM1 gene single nucleotide polymorphisms (rs758502 C/T, rs2302217 A/G, rs3745925 G/T) were genotyped by polymerase chain reaction with sequence-specific primers in 87 Czech, HLA-identical donor-recipient aHSCT pairs. MADCAM1 rs2302217 AA homozygous recipients developed chronic GVHD more frequently than patients with other genotypes ( 65% vs. 34%; p = 0.025). Furthermore, multivariate analysis revealed the MADCAM1 rs2302217 AA genotype in recipient being also an independent factor associated with development of acute GVHD ( p = 0.036) and decreased overall survival ( p = 0.001). These data suggest that MADCAM1 gene polymorphisms may be associated with the risk of chronic GVHD and may, also, affect mortality related to aHSCT.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2009.03.008</identifier><identifier>PMID: 19286444</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Allergy and Immunology ; Female ; Graft vs Host Disease - genetics ; Graft vs Host Disease - mortality ; Graft-versus-host disease ; Hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Immunoglobulins - genetics ; MAdCAM-1 ; Male ; Middle Aged ; Mucoproteins - genetics ; Multivariate Analysis ; Overall survival ; Polymorphism, Single Nucleotide ; Single nucleotide polymorphism ; Transplantation, Homologous ; Treatment Outcome ; Young Adult</subject><ispartof>Human immunology, 2009-06, Vol.70 (6), p.457-460</ispartof><rights>American Society for Histocompatibility and Immunogenetics</rights><rights>2009 American Society for Histocompatibility and Immunogenetics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-790ac4c0e487a2836d7a74ffb610714a6ca6ec4b8543c74f835e128e34a000b43</citedby><cites>FETCH-LOGICAL-c415t-790ac4c0e487a2836d7a74ffb610714a6ca6ec4b8543c74f835e128e34a000b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humimm.2009.03.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19286444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambruzova, Zuzana</creatorcontrib><creatorcontrib>Mrazek, Frantisek</creatorcontrib><creatorcontrib>Raida, Ludek</creatorcontrib><creatorcontrib>Stahelova, Anna</creatorcontrib><creatorcontrib>Faber, Edgar</creatorcontrib><creatorcontrib>Indrak, Karel</creatorcontrib><creatorcontrib>Petrek, Martin</creatorcontrib><title>Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Abstract Mucosal addressin cell adhesion molecule–1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. Three MADCAM1 gene single nucleotide polymorphisms (rs758502 C/T, rs2302217 A/G, rs3745925 G/T) were genotyped by polymerase chain reaction with sequence-specific primers in 87 Czech, HLA-identical donor-recipient aHSCT pairs. MADCAM1 rs2302217 AA homozygous recipients developed chronic GVHD more frequently than patients with other genotypes ( 65% vs. 34%; p = 0.025). Furthermore, multivariate analysis revealed the MADCAM1 rs2302217 AA genotype in recipient being also an independent factor associated with development of acute GVHD ( p = 0.036) and decreased overall survival ( p = 0.001). These data suggest that MADCAM1 gene polymorphisms may be associated with the risk of chronic GVHD and may, also, affect mortality related to aHSCT.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Female</subject><subject>Graft vs Host Disease - genetics</subject><subject>Graft vs Host Disease - mortality</subject><subject>Graft-versus-host disease</subject><subject>Hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Immunoglobulins - genetics</subject><subject>MAdCAM-1</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucoproteins - genetics</subject><subject>Multivariate Analysis</subject><subject>Overall survival</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Single nucleotide polymorphism</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-LFDEQxRtR3NnVbyCSk7duK92Z7vRFGGZ1FXZRUM8hna7eyZg_bZIW5u4HN80MCF48FaHee5X6UUXxikJFgbZvj9VhsdraqgboK2gqAP6k2FDe9SWlbfu02ADtecn5tr8qrmM8AkAHHXteXNG-5i1jbFP8_uJj1INBou0sVSJ-Ig-72_3ugZJHdEiido-56xZl0Cc9Ipm9OVkf5oOONpLkSTog8UtS3uJql8b41aoVOaCVyc9eY8qvmNAShcaQFKSLs5EuyaS9e1E8m6SJ-PJSb4rvH95_238s7z_ffdrv7kvF6DaVXQ9SMQXIeCdr3rRjJzs2TUNLoaNMtkq2qNjAt6xRucGbLdKaY8NkXn1gzU3x5pw7B_9zwZiE1XH9kHTolyhqWKn0dRays1CFjCfgJOagrQwnQUGs9MVRnOmLlb6ARmT62fb6kr8MFse_pgvuLHh3FmDe8pfGIKLS6BSOOqBKYvT6fxP-DVBGO62k-YEnjEe_BJcJCipiLUB8XS9gPQDoM4G26Zs_cKivLg</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Ambruzova, Zuzana</creator><creator>Mrazek, Frantisek</creator><creator>Raida, Ludek</creator><creator>Stahelova, Anna</creator><creator>Faber, Edgar</creator><creator>Indrak, Karel</creator><creator>Petrek, Martin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20090601</creationdate><title>Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation</title><author>Ambruzova, Zuzana ; Mrazek, Frantisek ; Raida, Ludek ; Stahelova, Anna ; Faber, Edgar ; Indrak, Karel ; Petrek, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-790ac4c0e487a2836d7a74ffb610714a6ca6ec4b8543c74f835e128e34a000b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Female</topic><topic>Graft vs Host Disease - genetics</topic><topic>Graft vs Host Disease - mortality</topic><topic>Graft-versus-host disease</topic><topic>Hematopoietic stem cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Immunoglobulins - genetics</topic><topic>MAdCAM-1</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucoproteins - genetics</topic><topic>Multivariate Analysis</topic><topic>Overall survival</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Single nucleotide polymorphism</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ambruzova, Zuzana</creatorcontrib><creatorcontrib>Mrazek, Frantisek</creatorcontrib><creatorcontrib>Raida, Ludek</creatorcontrib><creatorcontrib>Stahelova, Anna</creatorcontrib><creatorcontrib>Faber, Edgar</creatorcontrib><creatorcontrib>Indrak, Karel</creatorcontrib><creatorcontrib>Petrek, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ambruzova, Zuzana</au><au>Mrazek, Frantisek</au><au>Raida, Ludek</au><au>Stahelova, Anna</au><au>Faber, Edgar</au><au>Indrak, Karel</au><au>Petrek, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>70</volume><issue>6</issue><spage>457</spage><epage>460</epage><pages>457-460</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>Abstract Mucosal addressin cell adhesion molecule–1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. Three MADCAM1 gene single nucleotide polymorphisms (rs758502 C/T, rs2302217 A/G, rs3745925 G/T) were genotyped by polymerase chain reaction with sequence-specific primers in 87 Czech, HLA-identical donor-recipient aHSCT pairs. MADCAM1 rs2302217 AA homozygous recipients developed chronic GVHD more frequently than patients with other genotypes ( 65% vs. 34%; p = 0.025). Furthermore, multivariate analysis revealed the MADCAM1 rs2302217 AA genotype in recipient being also an independent factor associated with development of acute GVHD ( p = 0.036) and decreased overall survival ( p = 0.001). These data suggest that MADCAM1 gene polymorphisms may be associated with the risk of chronic GVHD and may, also, affect mortality related to aHSCT.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19286444</pmid><doi>10.1016/j.humimm.2009.03.008</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Allergy and Immunology Female Graft vs Host Disease - genetics Graft vs Host Disease - mortality Graft-versus-host disease Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Humans Immunoglobulins - genetics MAdCAM-1 Male Middle Aged Mucoproteins - genetics Multivariate Analysis Overall survival Polymorphism, Single Nucleotide Single nucleotide polymorphism Transplantation, Homologous Treatment Outcome Young Adult |
| title | Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation |
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