Identification of phosphatidylinositol 4-kinase type II β as HLA class II-restricted target in graft versus leukemia reactivity

Patients with hematological malignancies can be successfully treated with HLA-matched T cell-depleted allogeneic stem cell transplantation (alloSCT) and subsequent donor lymphocyte infusions (DLIs). The efficacy of DLI is mediated by donor T cells recognizing minor histocompatibility antigens (mHags...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-03, Vol.105 (10), p.3837-3842
Hauptverfasser:	Griffioen, Marieke, van der Meijden, Edith D, Slager, Elisabeth H, Honders, M. Willy, Rutten, Caroline E, van Luxemburg-Heijs, Simone A.P, von dem Borne, Peter A, van Rood, Johannes J, Willemze, Roel, Falkenburg, J.H. Frederik
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 4-Kinase - chemistry 1-Phosphatidylinositol 4-Kinase - immunology Amino Acid Sequence B lymphocytes Bacteria Base Sequence Biological Sciences Blood CD4-Positive T-Lymphocytes - immunology Cell Separation Chronic myeloid leukemia Clone Cells Complementary DNA DNA, Complementary - genetics Epitopes - chemistry Epitopes - immunology Graft vs Host Reaction - immunology Hematopoietic System - cytology Hematopoietic System - immunology Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - immunology HLA antigens HLA-DQ Antigens - immunology HLA-DQ beta-Chains Humans Leukemia - enzymology Leukemia - immunology Molecular Sequence Data Myeloid cells Organ Specificity Peptides - chemistry Peptides - immunology Reactivity T lymphocytes Tissue grafting
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