Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage, Leading to Diminished Zidovudine Excision

Previous biochemical studies have demonstrated that synergy between non-nucleoside reverse transcriptase (RT) inhibitors (NNRTI) and nucleoside RT inhibitors (NRTIs) is due to inhibition by the NNRTI of the rate at which HIV-1 RT facilitates ATP-mediated excision of NRTIs from chain-terminated templ...

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Veröffentlicht in:	Molecular pharmacology 2008-02, Vol.73 (2), p.601-606
Hauptverfasser:	Radzio, Jessica, Sluis-Cremer, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Benzoxazines - pharmacology DNA Repair - drug effects DNA Repair - physiology HIV Reverse Transcriptase - genetics HIV Reverse Transcriptase - metabolism HIV-1 - drug effects HIV-1 - enzymology Human immunodeficiency virus 1 Humans Ribonuclease H, Human Immunodeficiency Virus - genetics Ribonuclease H, Human Immunodeficiency Virus - metabolism Zidovudine - antagonists & inhibitors Zidovudine - pharmacology
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