Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia

Three new glabretal-type triperpenoids, aglaiaglabretols A–C, and nine known compounds, were isolated from the bark of Aglaia crassinervia. The cytotoxic activity of all isolates and several chemical transformation products was evaluated. The known cyclopenta[ b]benzofuran, rocaglaol, was found to b...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-02, Vol.14 (4), p.960-972
Hauptverfasser:	Su, Bao-Ning, Chai, Heebyung, Mi, Qiuwen, Riswan, Soedarsono, Kardono, Leonardus B.S., Afriastini, Johar J., Santarsiero, Bernard D., Mesecar, Andrew D., Farnsworth, Norman R., Cordell, Geoffrey A., Swanson, Steven M., Kinghorn, A. Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aglaia - chemistry Aglaia crassinervia Aglaiaglabretols A–C Animals Biological and medical sciences Cells, Cultured Cytotoxicity General pharmacology Glabretal triperpenoids Hollow fiber assay Humans Indonesia Magnetic Resonance Spectroscopy Medical sciences Meliaceae Mice Molecular Structure Mosher ester method Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Plant Extracts - isolation & purification Plant Extracts - toxicity Single-crystal X-ray analysis Stereoisomerism
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