In vitro inhibition potential of mono‐n‐octyl phthalate on Mycobacterium tuberculosis H37Ra: Possibility of binding to mycobacterial PknB—An in silico approach

Fatty acids of specific chain lengths have been shown to inhibit the growth of Mycobacterium tuberculosis. In the present study, specific synthetic aromatic derivatives of n‐octyl esters were investigated for their property to inhibit the growth of M. tuberculosis H37Ra. Agar well diffusion assay in...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2018-11, Vol.65 (6), p.865-875
Hauptverfasser:	Rajiniraja, Muniyan, Sivaramakrishna, Akella, Sabareesh, Varatharajan, Jayaraman, Gurunathan
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Anhydrides antimycobacterial activity Binding Biological activity bio‐autography Derivatives Esterification Esters Fatty acids Fractionation GC–MS in situ acid hydrolysis Inhibition Kinases Magnetic resonance spectroscopy Mass spectrometry Mass spectroscopy Molecular docking Molecular dynamics Mycobacterium tuberculosis NMR spectroscopy Octanol octyl phthalate Phthalic acid Phthalic anhydride Proteins Tuberculosis
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