Sequential Biochemical and Mechanical Stimulation in the Development of Tissue-Engineered Ligaments

Application of stimuli in sequence to developing cultures in vitro offers the potential to intricately direct cell development and differentiation by following the template of native tissue behavior. We hypothesize that administration of mechanical stimulation at the peak of growth factor-induced ce...

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Veröffentlicht in:	Tissue engineering. Part A 2008-07, Vol.14 (7), p.1161-1172
Hauptverfasser:	Moreau, Jodie E., Bramono, Diah S., Horan, Rebecca L., Kaplan, David L., Altman, Gregory H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biochemistry Biomechanics Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell culture Cell Culture Techniques Cell differentiation Cell Differentiation - drug effects Cell growth Cells, Cultured Epidermal Growth Factor - pharmacology Extracellular Matrix - metabolism Extracellular Matrix Proteins - biosynthesis Female Fibroblast Growth Factor 2 - pharmacology Fibroblasts - cytology Fibroblasts - metabolism Health aspects Humans Ligaments Male Methods Physiological aspects Silk Stress, Mechanical Stromal Cells - cytology Stromal Cells - metabolism Time Factors Tissue engineering Tissue Engineering - methods
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