Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization

Abstract We have expressed A-FOS, an inhibitor of activator protein-1 (AP-1) DNA binding, in adult mouse striatal neurons. We observed normal behavior including locomotion and exploratory activities. Following a single injection of cocaine, locomotion increased similarly in both the A-FOS expressing...

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Veröffentlicht in:	Neuroscience 2008-04, Vol.152 (4), p.1040-1053
Hauptverfasser:	Paletzki, R.F, Myakishev, M.V, Polesskaya, O, Orosz, A, Hyman, S.E, Vinson, C
Format:	Artikel
Sprache:	eng
Schlagworte:	A-FOS addiction Age Factors Animals Animals, Newborn Behavior, Animal - drug effects Biological and medical sciences Chromosome Mapping - methods Cocaine - pharmacology Cocaine-Related Disorders - genetics Cocaine-Related Disorders - physiopathology Corpus Striatum - drug effects Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Exploratory Behavior - drug effects Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Locomotion - drug effects Medical sciences Mice Mice, Transgenic Microarray Analysis - methods Neurology Neuropharmacology Pharmacology. Drug treatments Phosphopyruvate Hydratase - genetics Phosphopyruvate Hydratase - metabolism Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Replication Protein C - genetics Replication Protein C - metabolism RNA, Messenger - metabolism sensitization Time Factors Vertebrates: nervous system and sense organs
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