Cytochrome c6A is a funnel for thiol oxidation in the thylakoid lumen

Cytochrome c6A is a funnel for thiol oxidation in the thylakoid lumen

Cytochrome c6A is a dithio-cytochrome recently discovered in land plants and green algae, and believed to be derived from the well-known cytochrome c6. The function of cytochrome c6A is unclear. We propose that it catalyses the formation of disulphide bridges in thylakoid lumen proteins in a single-...

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Veröffentlicht in:FEBS letters 2006-04, Vol.580 (9), p.2166-2169
Hauptverfasser: Schlarb-Ridley, Beatrix G, Nimmo, Robert H, Purton, Saul, Howe, Christopher J, Bendall, Derek S
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creator Schlarb-Ridley, Beatrix G
Nimmo, Robert H
Purton, Saul
Howe, Christopher J
Bendall, Derek S
description Cytochrome c6A is a dithio-cytochrome recently discovered in land plants and green algae, and believed to be derived from the well-known cytochrome c6. The function of cytochrome c6A is unclear. We propose that it catalyses the formation of disulphide bridges in thylakoid lumen proteins in a single-step disulphide exchange reaction, with subsequent transfer of the reducing equivalents to plastocyanin. The haem group of cytochrome c6A acts as an electron sink, allowing rapid resolution of a radical intermediate formed during reoxidation of cytochrome c6A. Our model is consistent with previously published data on mutant plants, and the likely evolution of the protein.
doi_str_mv 10.1016/j.febslet.2006.03.052
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title Cytochrome c6A is a funnel for thiol oxidation in the thylakoid lumen
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