In vivo photochemical skin micronucleus test using a sunlight simulator: Detection of 8-methoxypsoralen and benzo[a]pyrene in hairless mice

Evaluating in vivo photochemical genotoxicity (photogenotoxicity) or photochemical carcinogenicity (photocarcinogenicity) in the skin that is actually exposed to light is important for estimating the risk of human exposure to chemicals under sunlight. With regard to the skin micronucleus test, Nishi...

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Veröffentlicht in:	Mutation research 2007-07, Vol.631 (1), p.1-8
Hauptverfasser:	Hara, Takumi, Nishikawa, Takashi, Sui, Hajime, Kawakami, Kumiko, Matsumoto, Hirotaka, Tanaka, Noriho
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Methoxypsoralen Animals Benzo(a)pyrene - toxicity Benzo[a]pyrene Biological and medical sciences Dermatitis, Phototoxic - genetics Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Humans Male Medical sciences Methoxsalen - toxicity Mice Mice, Hairless Micronucleus Tests Mutagens - toxicity Photobiology Photochemical genotoxicity Skin - drug effects Skin - radiation effects Skin micronucleus test Sunlight - adverse effects Toxicology
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