Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo( a)pyrene and their mode of action
In recent years, rocket plant ( Eruca sativa) has gained greater importance as a vegetable and spice, especially among Europeans. E. sativa is a member of the Brassicaceae, which is considered to be an important chemopreventive plant family. In the present study, we assessed the chemopreventive pote...
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| Veröffentlicht in: | Food and chemical toxicology 2008-07, Vol.46 (7), p.2415-2421 |
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| creator | Lamy, Evelyn Schröder, Julia Paulus, Stefanie Brenk, Peter Stahl, Thorsten Mersch-Sundermann, Volker |
| description | In recent years, rocket plant (
Eruca sativa) has gained greater importance as a vegetable and spice, especially among Europeans.
E. sativa is a member of the Brassicaceae, which is considered to be an important chemopreventive plant family. In the present study, we assessed the chemopreventive potency and underlying mechanisms of extracts of
E. sativa in HepG2 cells. No genotoxic effect could be observed in HepG2 cells treated with up to 50
μl/ml plant juice for 24
h when using the comet assay. In antigenotoxicity experiments,
E. sativa extract reduced the benzo(
a)pyrene-induced genotoxicity in a U-shaped manner. This effect was accompanied by a significant induction of glutathione
S-transferase. No significant suppression of B(
a)P-induced CYP1A1 protein expression or enzyme activity could be observed. Chemical analysis of the plant material by gas chromatography identified the isothiocyanates erucin, sulforaphane, erysolin and phenylethyl isothiocyanate. Results derived with the single ITC compounds support the assumption that their synergistic interaction is responsible for the strong antigenotoxicity of the plant material. The present study provided an assessment of the bioactive effects of rocket plant extract in a human cell culture system. This could help to evaluate the balance between beneficial vs. possible adverse effects of rocket plant consumption. |
| doi_str_mv | 10.1016/j.fct.2008.03.022 |
| format | Article |
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Eruca sativa) has gained greater importance as a vegetable and spice, especially among Europeans.
E. sativa is a member of the Brassicaceae, which is considered to be an important chemopreventive plant family. In the present study, we assessed the chemopreventive potency and underlying mechanisms of extracts of
E. sativa in HepG2 cells. No genotoxic effect could be observed in HepG2 cells treated with up to 50
μl/ml plant juice for 24
h when using the comet assay. In antigenotoxicity experiments,
E. sativa extract reduced the benzo(
a)pyrene-induced genotoxicity in a U-shaped manner. This effect was accompanied by a significant induction of glutathione
S-transferase. No significant suppression of B(
a)P-induced CYP1A1 protein expression or enzyme activity could be observed. Chemical analysis of the plant material by gas chromatography identified the isothiocyanates erucin, sulforaphane, erysolin and phenylethyl isothiocyanate. Results derived with the single ITC compounds support the assumption that their synergistic interaction is responsible for the strong antigenotoxicity of the plant material. The present study provided an assessment of the bioactive effects of rocket plant extract in a human cell culture system. This could help to evaluate the balance between beneficial vs. possible adverse effects of rocket plant consumption.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2008.03.022</identifier><identifier>PMID: 18479797</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>anticarcinogenic activity ; Antigenotoxicity ; Antimutagenic Agents - analysis ; Antimutagenic Agents - pharmacology ; Benzo(a)pyrene - antagonists & inhibitors ; Benzo(a)pyrene - toxicity ; Biological and medical sciences ; Brassicaceae ; Brassicaceae - chemistry ; Carcinoma, Hepatocellular - drug therapy ; Cell Line, Tumor ; cell lines ; Chromatography, Gas ; Comet Assay ; cytochrome P-450 ; Cytochrome P-450 CYP1A1 - antagonists & inhibitors ; Cytochrome P-450 CYP1A1 - drug effects ; DNA Damage - drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; enzyme activity ; Enzyme Induction ; Eruca sativa ; erucin ; erysolin ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Regulation, Enzymologic ; genotoxicity ; glutathione transferase ; Glutathione Transferase - antagonists & inhibitors ; Glutathione Transferase - drug effects ; hepatoma ; HepG2 cells ; human diseases ; Humans ; isothiocyanates ; Liver Neoplasms - drug therapy ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mutagens ; phenylethyl isothiocyanate ; plant extracts ; Plant Extracts - analysis ; Plant Extracts - pharmacology ; Plant poisons toxicology ; protein synthesis ; Rocket plant ; Sulfides - analysis ; Sulfides - pharmacology ; Sulfones - analysis ; Sulfones - pharmacology ; sulforaphane ; synergism ; Thiocyanates - analysis ; Thiocyanates - pharmacology ; Toxicology ; Tumors</subject><ispartof>Food and chemical toxicology, 2008-07, Vol.46 (7), p.2415-2421</ispartof><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-fe22d7a35b0771075a972ebcda73875b3a1bad10f5c46038ea4a844c486243ed3</citedby><cites>FETCH-LOGICAL-c436t-fe22d7a35b0771075a972ebcda73875b3a1bad10f5c46038ea4a844c486243ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2008.03.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20444270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18479797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamy, Evelyn</creatorcontrib><creatorcontrib>Schröder, Julia</creatorcontrib><creatorcontrib>Paulus, Stefanie</creatorcontrib><creatorcontrib>Brenk, Peter</creatorcontrib><creatorcontrib>Stahl, Thorsten</creatorcontrib><creatorcontrib>Mersch-Sundermann, Volker</creatorcontrib><title>Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo( a)pyrene and their mode of action</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>In recent years, rocket plant (
Eruca sativa) has gained greater importance as a vegetable and spice, especially among Europeans.
E. sativa is a member of the Brassicaceae, which is considered to be an important chemopreventive plant family. In the present study, we assessed the chemopreventive potency and underlying mechanisms of extracts of
E. sativa in HepG2 cells. No genotoxic effect could be observed in HepG2 cells treated with up to 50
μl/ml plant juice for 24
h when using the comet assay. In antigenotoxicity experiments,
E. sativa extract reduced the benzo(
a)pyrene-induced genotoxicity in a U-shaped manner. This effect was accompanied by a significant induction of glutathione
S-transferase. No significant suppression of B(
a)P-induced CYP1A1 protein expression or enzyme activity could be observed. Chemical analysis of the plant material by gas chromatography identified the isothiocyanates erucin, sulforaphane, erysolin and phenylethyl isothiocyanate. Results derived with the single ITC compounds support the assumption that their synergistic interaction is responsible for the strong antigenotoxicity of the plant material. The present study provided an assessment of the bioactive effects of rocket plant extract in a human cell culture system. This could help to evaluate the balance between beneficial vs. possible adverse effects of rocket plant consumption.</description><subject>anticarcinogenic activity</subject><subject>Antigenotoxicity</subject><subject>Antimutagenic Agents - analysis</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>Benzo(a)pyrene - antagonists & inhibitors</subject><subject>Benzo(a)pyrene - toxicity</subject><subject>Biological and medical sciences</subject><subject>Brassicaceae</subject><subject>Brassicaceae - chemistry</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Cell Line, Tumor</subject><subject>cell lines</subject><subject>Chromatography, Gas</subject><subject>Comet Assay</subject><subject>cytochrome P-450</subject><subject>Cytochrome P-450 CYP1A1 - antagonists & inhibitors</subject><subject>Cytochrome P-450 CYP1A1 - drug effects</subject><subject>DNA Damage - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>enzyme activity</subject><subject>Enzyme Induction</subject><subject>Eruca sativa</subject><subject>erucin</subject><subject>erysolin</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>genotoxicity</subject><subject>glutathione transferase</subject><subject>Glutathione Transferase - antagonists & inhibitors</subject><subject>Glutathione Transferase - drug effects</subject><subject>hepatoma</subject><subject>HepG2 cells</subject><subject>human diseases</subject><subject>Humans</subject><subject>isothiocyanates</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mutagens</subject><subject>phenylethyl isothiocyanate</subject><subject>plant extracts</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant poisons toxicology</subject><subject>protein synthesis</subject><subject>Rocket plant</subject><subject>Sulfides - analysis</subject><subject>Sulfides - pharmacology</subject><subject>Sulfones - analysis</subject><subject>Sulfones - pharmacology</subject><subject>sulforaphane</subject><subject>synergism</subject><subject>Thiocyanates - analysis</subject><subject>Thiocyanates - pharmacology</subject><subject>Toxicology</subject><subject>Tumors</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEoqXwAGzAG1BHYobrn8SJWFVVaZEqsYCurRvnpvWQxKntKQzvwrviYUawQ7b8I3_n-tinKF5yWHHg1fv1qrdpJQDqFcgVCPGoOOa1lstKlvxxcQxC18uq4eVR8SzGNQBorqunxRGvlW5yOy5-nU3J3dLkk__hLJuDnykkR5H5nl2EjUUWMbkHZKfB22-U2DzglBbvGOVDNzGcurzcRj_kTe53mxHzSDMmP2bVFc2XYsEsDUNkyX_H0EXW0vTTnzJczNtAE_0pku7IBTb6jnZXo03OT8-LJz0OkV4c5pPi5uPF1_Or5fXny0_nZ9dLq2SVlj0J0WmUZQtac9AlNlpQazvUstZlK5G32HHoS6sqkDWhwlopq-pKKEmdPCne7uvm999vKCYzurizjBP5TTQCatVUoskg34M2-BgD9WYObsSwNRzMLhOzNjkTs8vEgDQ5k6x5dSi-aUfq_ikOIWTgzQHAaHHoA07Wxb-cAKWU0JC513uuR2_wNmTm5osALgEaUTVqZ-_DnqD8WQ-OgonW0WSpc4Gyrc67_xj9DTZwtBk</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Lamy, Evelyn</creator><creator>Schröder, Julia</creator><creator>Paulus, Stefanie</creator><creator>Brenk, Peter</creator><creator>Stahl, Thorsten</creator><creator>Mersch-Sundermann, Volker</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20080701</creationdate><title>Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo( a)pyrene and their mode of action</title><author>Lamy, Evelyn ; Schröder, Julia ; Paulus, Stefanie ; Brenk, Peter ; Stahl, Thorsten ; Mersch-Sundermann, Volker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-fe22d7a35b0771075a972ebcda73875b3a1bad10f5c46038ea4a844c486243ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>anticarcinogenic activity</topic><topic>Antigenotoxicity</topic><topic>Antimutagenic Agents - analysis</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>Benzo(a)pyrene - antagonists & inhibitors</topic><topic>Benzo(a)pyrene - toxicity</topic><topic>Biological and medical sciences</topic><topic>Brassicaceae</topic><topic>Brassicaceae - chemistry</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Cell Line, Tumor</topic><topic>cell lines</topic><topic>Chromatography, Gas</topic><topic>Comet Assay</topic><topic>cytochrome P-450</topic><topic>Cytochrome P-450 CYP1A1 - antagonists & inhibitors</topic><topic>Cytochrome P-450 CYP1A1 - drug effects</topic><topic>DNA Damage - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>enzyme activity</topic><topic>Enzyme Induction</topic><topic>Eruca sativa</topic><topic>erucin</topic><topic>erysolin</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>genotoxicity</topic><topic>glutathione transferase</topic><topic>Glutathione Transferase - antagonists & inhibitors</topic><topic>Glutathione Transferase - drug effects</topic><topic>hepatoma</topic><topic>HepG2 cells</topic><topic>human diseases</topic><topic>Humans</topic><topic>isothiocyanates</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Mutagens</topic><topic>phenylethyl isothiocyanate</topic><topic>plant extracts</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant poisons toxicology</topic><topic>protein synthesis</topic><topic>Rocket plant</topic><topic>Sulfides - analysis</topic><topic>Sulfides - pharmacology</topic><topic>Sulfones - analysis</topic><topic>Sulfones - pharmacology</topic><topic>sulforaphane</topic><topic>synergism</topic><topic>Thiocyanates - analysis</topic><topic>Thiocyanates - pharmacology</topic><topic>Toxicology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamy, Evelyn</creatorcontrib><creatorcontrib>Schröder, Julia</creatorcontrib><creatorcontrib>Paulus, Stefanie</creatorcontrib><creatorcontrib>Brenk, Peter</creatorcontrib><creatorcontrib>Stahl, Thorsten</creatorcontrib><creatorcontrib>Mersch-Sundermann, Volker</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamy, Evelyn</au><au>Schröder, Julia</au><au>Paulus, Stefanie</au><au>Brenk, Peter</au><au>Stahl, Thorsten</au><au>Mersch-Sundermann, Volker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo( a)pyrene and their mode of action</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>46</volume><issue>7</issue><spage>2415</spage><epage>2421</epage><pages>2415-2421</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>In recent years, rocket plant (
Eruca sativa) has gained greater importance as a vegetable and spice, especially among Europeans.
E. sativa is a member of the Brassicaceae, which is considered to be an important chemopreventive plant family. In the present study, we assessed the chemopreventive potency and underlying mechanisms of extracts of
E. sativa in HepG2 cells. No genotoxic effect could be observed in HepG2 cells treated with up to 50
μl/ml plant juice for 24
h when using the comet assay. In antigenotoxicity experiments,
E. sativa extract reduced the benzo(
a)pyrene-induced genotoxicity in a U-shaped manner. This effect was accompanied by a significant induction of glutathione
S-transferase. No significant suppression of B(
a)P-induced CYP1A1 protein expression or enzyme activity could be observed. Chemical analysis of the plant material by gas chromatography identified the isothiocyanates erucin, sulforaphane, erysolin and phenylethyl isothiocyanate. Results derived with the single ITC compounds support the assumption that their synergistic interaction is responsible for the strong antigenotoxicity of the plant material. The present study provided an assessment of the bioactive effects of rocket plant extract in a human cell culture system. This could help to evaluate the balance between beneficial vs. possible adverse effects of rocket plant consumption.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>18479797</pmid><doi>10.1016/j.fct.2008.03.022</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2008-07, Vol.46 (7), p.2415-2421 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20849629 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | anticarcinogenic activity Antigenotoxicity Antimutagenic Agents - analysis Antimutagenic Agents - pharmacology Benzo(a)pyrene - antagonists & inhibitors Benzo(a)pyrene - toxicity Biological and medical sciences Brassicaceae Brassicaceae - chemistry Carcinoma, Hepatocellular - drug therapy Cell Line, Tumor cell lines Chromatography, Gas Comet Assay cytochrome P-450 Cytochrome P-450 CYP1A1 - antagonists & inhibitors Cytochrome P-450 CYP1A1 - drug effects DNA Damage - drug effects Dose-Response Relationship, Drug Drug Synergism enzyme activity Enzyme Induction Eruca sativa erucin erysolin Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Enzymologic genotoxicity glutathione transferase Glutathione Transferase - antagonists & inhibitors Glutathione Transferase - drug effects hepatoma HepG2 cells human diseases Humans isothiocyanates Liver Neoplasms - drug therapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mutagens phenylethyl isothiocyanate plant extracts Plant Extracts - analysis Plant Extracts - pharmacology Plant poisons toxicology protein synthesis Rocket plant Sulfides - analysis Sulfides - pharmacology Sulfones - analysis Sulfones - pharmacology sulforaphane synergism Thiocyanates - analysis Thiocyanates - pharmacology Toxicology Tumors |
| title | Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo( a)pyrene and their mode of action |
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