Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice

Matrix metalloproteinases (MMPs) have been implicated in a variety of human diseases, including neuroimmunological disorders such as multiple sclerosis. However, the recent finding that some MMPs play paradoxical protective roles in these diseases has made necessary the detailed study of the specifi...

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Veröffentlicht in:	The Journal of biological chemistry 2008-04, Vol.283 (14), p.9465-9474
Hauptverfasser:	Folgueras, Alicia R., Fueyo, Antonio, García-Suárez, Olivia, Cox, Jennifer, Astudillo, Aurora, Tortorella, Paolo, Campestre, Cristina, Gutiérrez-Fernández, Ana, Fanjul-Fernández, Miriam, Pennington, Caroline J., Edwards, Dylan R., Overall, Christopher M., López-Otín, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System - enzymology Central Nervous System - pathology Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - enzymology Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - pathology Female Humans Matrix Metalloproteinase 8 - genetics Matrix Metalloproteinase 8 - metabolism Matrix Metalloproteinase Inhibitors Mice Mice, Knockout Multiple Sclerosis - drug therapy Multiple Sclerosis - enzymology Multiple Sclerosis - genetics Multiple Sclerosis - pathology Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use
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