The TGFβ-ERK pathway contributes to Notch3 upregulation in the renal tubular epithelial cells of patients with obstructive nephropathy

Renal interstitial fibrosis is a common renal injury resulted from a variety of chronic kidney conditions and an array of factors. We report here that Notch3 is a potential contributor. In comparison to 6 healthy individuals, a robust elevation of Notch3 expression was observed in the renal tubular...

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Veröffentlicht in:	Cellular signalling 2018-11, Vol.51, p.139-151
Hauptverfasser:	Huang, Mei, Zhang, Jin, Xu, Hui, Ding, Ting, Tang, Damu, Yuan, Qiongjing, Tao, Lijian, Ye, Zunlong
Format:	Artikel
Sprache:	eng
Schlagworte:	ERK Fibrosis, Notch3 Obstructive nephropathy TGFβ UUO model
Online-Zugang:	Volltext
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