1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity

1,2,3-triazole tethered Indole-3-glyoxamide derivatives demonstrated excellent anti-proliferative activities through COX-2/5-LOX dual inhibition. [Display omitted] •A series of 1,2,3-triazole tethered Indole-3-glyoxamide derivatives were synthesized.•Compounds were evaluated for their anti-prolifera...

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Veröffentlicht in:	Bioorganic chemistry 2018-12, Vol.81, p.1-20
Hauptverfasser:	Naaz, Fatima, Preeti Pallavi, M.C., Shafi, Syed, Mulakayala, Naveen, Shahar Yar, M., Sampath Kumar, H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-triazoles 5-LOX Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-proliferation Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Arachidonate 5-Lipoxygenase - metabolism Cell Line, Tumor Cell Proliferation - drug effects COX-1 COX-2 Cyclooxygenase 2 - metabolism Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Indole-3-glyoxamide derivatives Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Molecular Docking Simulation Molecular Structure Structure-Activity Relationship Sulfonylurea Compounds - chemical synthesis Sulfonylurea Compounds - chemistry Sulfonylurea Compounds - pharmacology Triazoles - chemistry Triazoles - pharmacology Tubulin Tubulin - metabolism
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