Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications
As a herb of the ginger family, the turmeric plant has been used as spice and colorant in the Oriental countries. The rhizome part of the plant is rich in curcumin, which has been proven to be the main ingredient responsible for turmeric's biological effects. Most research endeavors have been u...
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| Veröffentlicht in: | Macromolecular rapid communications. 2019-03, Vol.40 (5), p.e1800216-n/a |
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| creator | Liu, Minghuan Teng, Choon Peng Win, Khin Yin Chen, Yisong Zhang, Xiaoyan Yang, Da‐Peng Li, Zibiao Ye, Enyi |
| description | As a herb of the ginger family, the turmeric plant has been used as spice and colorant in the Oriental countries. The rhizome part of the plant is rich in curcumin, which has been proven to be the main ingredient responsible for turmeric's biological effects. Most research endeavors have been upon the investigation of pharmaceutical activities of curcumin, yet the fluorescence of curcumin is a bit far from well‐studied. The major drawbacks associated with curcumin are its poor aqueous solubility and low stability. In this communication, the encapsulation of fluorescent turmeric extract into polymeric nanoparticles (NPs) for bioimaging and antibacterial applications is reported. Through poly(d,l‐lactic‐co‐glycolic acid) (PLGA) encapsulation, solubility of curcumin is greatly increased, and the biodegradable nature of PLGA further enhances the biocompatibility of curcumin. These Cur‐PLGA NPs are successfully demonstrated to be efficient fluorescence probes for bioimaging, and promising for antibacterial application.
As the major ingredient in turmeric extract, curcumin exhibits strong fluorescence and potential antibacterial activity. Poor water solubility of curcumin is overcome by incorporating into poly(d,l‐lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs). Bioimaging of live cells and the antibacterial effect against Escherichia coli and Staphylococcus aureus using curcumin‐incorporated PLGA NPs are successfully demonstrated. |
| doi_str_mv | 10.1002/marc.201800216 |
| format | Article |
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As the major ingredient in turmeric extract, curcumin exhibits strong fluorescence and potential antibacterial activity. Poor water solubility of curcumin is overcome by incorporating into poly(d,l‐lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs). Bioimaging of live cells and the antibacterial effect against Escherichia coli and Staphylococcus aureus using curcumin‐incorporated PLGA NPs are successfully demonstrated.</description><identifier>ISSN: 1022-1336</identifier><identifier>EISSN: 1521-3927</identifier><identifier>DOI: 10.1002/marc.201800216</identifier><identifier>PMID: 30085362</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Anti-Infective Agents - pharmacology ; antibacterial ; Antiinfectives and antibacterials ; Biocompatibility ; Biodegradability ; Biodegradation ; bioimaging ; Biological effects ; Cell Death - drug effects ; Cell Line, Tumor ; Curcuma - chemistry ; Curcumin ; Diagnostic Imaging ; Drug Compounding ; Encapsulation ; Escherichia coli - drug effects ; Fluorescence ; fluorescent curcumin ; Fluorescent indicators ; Ginger ; Glycolic acid ; Humans ; Medical imaging ; Microbial Sensitivity Tests ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry ; Polylactide-co-glycolide ; polymer encapsulation ; Polymers - chemistry ; Solubility ; Staphylococcus aureus - drug effects ; turmeric extract</subject><ispartof>Macromolecular rapid communications., 2019-03, Vol.40 (5), p.e1800216-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3736-59dda166f048fa9ca26b7926eb5f8749c7478729bed385545d71f76b4690a80c3</citedby><cites>FETCH-LOGICAL-c3736-59dda166f048fa9ca26b7926eb5f8749c7478729bed385545d71f76b4690a80c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmarc.201800216$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmarc.201800216$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30085362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Minghuan</creatorcontrib><creatorcontrib>Teng, Choon Peng</creatorcontrib><creatorcontrib>Win, Khin Yin</creatorcontrib><creatorcontrib>Chen, Yisong</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Yang, Da‐Peng</creatorcontrib><creatorcontrib>Li, Zibiao</creatorcontrib><creatorcontrib>Ye, Enyi</creatorcontrib><title>Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications</title><title>Macromolecular rapid communications.</title><addtitle>Macromol Rapid Commun</addtitle><description>As a herb of the ginger family, the turmeric plant has been used as spice and colorant in the Oriental countries. The rhizome part of the plant is rich in curcumin, which has been proven to be the main ingredient responsible for turmeric's biological effects. Most research endeavors have been upon the investigation of pharmaceutical activities of curcumin, yet the fluorescence of curcumin is a bit far from well‐studied. The major drawbacks associated with curcumin are its poor aqueous solubility and low stability. In this communication, the encapsulation of fluorescent turmeric extract into polymeric nanoparticles (NPs) for bioimaging and antibacterial applications is reported. Through poly(d,l‐lactic‐co‐glycolic acid) (PLGA) encapsulation, solubility of curcumin is greatly increased, and the biodegradable nature of PLGA further enhances the biocompatibility of curcumin. These Cur‐PLGA NPs are successfully demonstrated to be efficient fluorescence probes for bioimaging, and promising for antibacterial application.
As the major ingredient in turmeric extract, curcumin exhibits strong fluorescence and potential antibacterial activity. Poor water solubility of curcumin is overcome by incorporating into poly(d,l‐lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs). Bioimaging of live cells and the antibacterial effect against Escherichia coli and Staphylococcus aureus using curcumin‐incorporated PLGA NPs are successfully demonstrated.</description><subject>Anti-Infective Agents - pharmacology</subject><subject>antibacterial</subject><subject>Antiinfectives and antibacterials</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>bioimaging</subject><subject>Biological effects</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Curcuma - chemistry</subject><subject>Curcumin</subject><subject>Diagnostic Imaging</subject><subject>Drug Compounding</subject><subject>Encapsulation</subject><subject>Escherichia coli - drug effects</subject><subject>Fluorescence</subject><subject>fluorescent curcumin</subject><subject>Fluorescent indicators</subject><subject>Ginger</subject><subject>Glycolic acid</subject><subject>Humans</subject><subject>Medical imaging</subject><subject>Microbial Sensitivity Tests</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Polylactic Acid-Polyglycolic Acid Copolymer - chemistry</subject><subject>Polylactide-co-glycolide</subject><subject>polymer encapsulation</subject><subject>Polymers - chemistry</subject><subject>Solubility</subject><subject>Staphylococcus aureus - drug effects</subject><subject>turmeric extract</subject><issn>1022-1336</issn><issn>1521-3927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LwzAYh4Mobk6vHqXgxUtnPtp8HOeYHzBRRA-eQpqmEmmbmrTo_nszNxW8eMob8uTh_f0AOEZwiiDE543yeooh4vGC6A4YoxyjlAjMduMMMU4RIXQEDkJ4hRDyDOJ9MCJxygnFY_B87-pVY7zVyaLVqgtDrXrr2sRVyePgty8fvVe6TyrnkwvrbKNebPuSqLZMZm1vG6u9K6yqk1nX1VZ_CcIh2KtUHczR9pyAp8vF4_w6Xd5d3cxny1QTRmiai7JUiNIKZrxSQitMCyYwNUVecZYJzTLGGRaFKQnP8ywvGaoYLTIqoOJQkwk423g7794GE3rZ2KBNXavWuCFIHEMLDBmCET39g766wbdxO4kRZ4ILxtbUdEPFVCF4U8nOx8h-JRGU69LlunT5U3r8cLLVDkVjyh_8u-UIiA3wbmuz-kcnb2cP81_5J4LxjWI</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Liu, Minghuan</creator><creator>Teng, Choon Peng</creator><creator>Win, Khin Yin</creator><creator>Chen, Yisong</creator><creator>Zhang, Xiaoyan</creator><creator>Yang, Da‐Peng</creator><creator>Li, Zibiao</creator><creator>Ye, Enyi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>JG9</scope><scope>JQ2</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201903</creationdate><title>Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications</title><author>Liu, Minghuan ; Teng, Choon Peng ; Win, Khin Yin ; Chen, Yisong ; Zhang, Xiaoyan ; Yang, Da‐Peng ; Li, Zibiao ; Ye, Enyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3736-59dda166f048fa9ca26b7926eb5f8749c7478729bed385545d71f76b4690a80c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anti-Infective Agents - pharmacology</topic><topic>antibacterial</topic><topic>Antiinfectives and antibacterials</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>bioimaging</topic><topic>Biological effects</topic><topic>Cell Death - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Curcuma - chemistry</topic><topic>Curcumin</topic><topic>Diagnostic Imaging</topic><topic>Drug Compounding</topic><topic>Encapsulation</topic><topic>Escherichia coli - drug effects</topic><topic>Fluorescence</topic><topic>fluorescent curcumin</topic><topic>Fluorescent indicators</topic><topic>Ginger</topic><topic>Glycolic acid</topic><topic>Humans</topic><topic>Medical imaging</topic><topic>Microbial Sensitivity Tests</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Polylactic Acid-Polyglycolic Acid Copolymer - chemistry</topic><topic>Polylactide-co-glycolide</topic><topic>polymer encapsulation</topic><topic>Polymers - chemistry</topic><topic>Solubility</topic><topic>Staphylococcus aureus - drug effects</topic><topic>turmeric extract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Minghuan</creatorcontrib><creatorcontrib>Teng, Choon Peng</creatorcontrib><creatorcontrib>Win, Khin Yin</creatorcontrib><creatorcontrib>Chen, Yisong</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Yang, Da‐Peng</creatorcontrib><creatorcontrib>Li, Zibiao</creatorcontrib><creatorcontrib>Ye, Enyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular rapid communications.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Minghuan</au><au>Teng, Choon Peng</au><au>Win, Khin Yin</au><au>Chen, Yisong</au><au>Zhang, Xiaoyan</au><au>Yang, Da‐Peng</au><au>Li, Zibiao</au><au>Ye, Enyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications</atitle><jtitle>Macromolecular rapid communications.</jtitle><addtitle>Macromol Rapid Commun</addtitle><date>2019-03</date><risdate>2019</risdate><volume>40</volume><issue>5</issue><spage>e1800216</spage><epage>n/a</epage><pages>e1800216-n/a</pages><issn>1022-1336</issn><eissn>1521-3927</eissn><abstract>As a herb of the ginger family, the turmeric plant has been used as spice and colorant in the Oriental countries. The rhizome part of the plant is rich in curcumin, which has been proven to be the main ingredient responsible for turmeric's biological effects. Most research endeavors have been upon the investigation of pharmaceutical activities of curcumin, yet the fluorescence of curcumin is a bit far from well‐studied. The major drawbacks associated with curcumin are its poor aqueous solubility and low stability. In this communication, the encapsulation of fluorescent turmeric extract into polymeric nanoparticles (NPs) for bioimaging and antibacterial applications is reported. Through poly(d,l‐lactic‐co‐glycolic acid) (PLGA) encapsulation, solubility of curcumin is greatly increased, and the biodegradable nature of PLGA further enhances the biocompatibility of curcumin. These Cur‐PLGA NPs are successfully demonstrated to be efficient fluorescence probes for bioimaging, and promising for antibacterial application.
As the major ingredient in turmeric extract, curcumin exhibits strong fluorescence and potential antibacterial activity. Poor water solubility of curcumin is overcome by incorporating into poly(d,l‐lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs). Bioimaging of live cells and the antibacterial effect against Escherichia coli and Staphylococcus aureus using curcumin‐incorporated PLGA NPs are successfully demonstrated.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30085362</pmid><doi>10.1002/marc.201800216</doi><tpages>7</tpages></addata></record> |
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| subjects | Anti-Infective Agents - pharmacology antibacterial Antiinfectives and antibacterials Biocompatibility Biodegradability Biodegradation bioimaging Biological effects Cell Death - drug effects Cell Line, Tumor Curcuma - chemistry Curcumin Diagnostic Imaging Drug Compounding Encapsulation Escherichia coli - drug effects Fluorescence fluorescent curcumin Fluorescent indicators Ginger Glycolic acid Humans Medical imaging Microbial Sensitivity Tests Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Plant Extracts - chemistry Plant Extracts - pharmacology Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polylactide-co-glycolide polymer encapsulation Polymers - chemistry Solubility Staphylococcus aureus - drug effects turmeric extract |
| title | Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications |
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