Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Abstract Aims Monocyte-mediated inflammation is a major mechanism underlying myocardial ischaemia–reperfusion (IR) injury and the healing process after acute myocardial infarction (AMI). However, no definitive anti-inflammatory therapies have been developed for clinical use. Pioglitazone, a peroxiso...

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Veröffentlicht in:	Cardiovascular research 2019-02, Vol.115 (2), p.419-431
Hauptverfasser:	Tokutome, Masaki, Matoba, Tetsuya, Nakano, Yasuhiro, Okahara, Arihide, Fujiwara, Masaki, Koga, Jun-Ichiro, Nakano, Kaku, Tsutsui, Hiroyuki, Egashira, Kensuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Disease Models, Animal Drug Carriers Injections, Intravenous Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Male Mice, Inbred C57BL Mice, Knockout Monocytes - drug effects Monocytes - metabolism Monocytes - pathology Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardium - metabolism Myocardium - pathology Nanoparticles Pioglitazone - administration & dosage Pioglitazone - chemistry Pioglitazone - pharmacology Polylactic Acid-Polyglycolic Acid Copolymer - chemistry PPAR gamma - agonists PPAR gamma - metabolism Receptors, CCR2 - genetics Receptors, CCR2 - metabolism Signal Transduction Swine Swine, Miniature Wound Healing - drug effects
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