New steroidal alkaloid and furostanol glycosides isolated from Solanum lyratum with cytotoxicity
Two previously undescribed steroidal compounds, 16, 23-epoxy-22, 26-epimino-cholest-22(N), 23, 25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-(25R)-5α-furost-20(22)-en-3β, 26-diol (2), together with 7 known ones includin...
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| Veröffentlicht in: | Chinese journal of natural medicines 2018-07, Vol.16 (7), p.499-504 |
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| creator | XU, Yun-Ling LV, Jia WANG, Wei-Fang LIU, Yue XU, Ya-Juan XU, Tun-Hai |
| description | Two previously undescribed steroidal compounds, 16, 23-epoxy-22, 26-epimino-cholest-22(N), 23, 25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-(25R)-5α-furost-20(22)-en-3β, 26-diol (2), together with 7 known ones including 26-O-β-D-glucopyranosyl-(25R)-5, 20(22)-dien-furost-3β, 26-diol (3), (25R)-5-en-spirost-3β-ol-O-β-D-glucopyranosyl-(1→4)-[α-L-rhmanopyranosyl-(1→2)]-β-D-galactopyranoside (4), funkioside D (5), aspidistrin (6), tigogenin-3-O-β-D-lucotrioside (7), desglucolanatigonin II (8), and degalactotigonin (9), were isolated from Solanum lyratum Thunb. Their cytotoxic activities were tested in two cancer cell lines by MTT method. One of the steroidal glycosides (6) showed significant cytotoxic activity against gastric cancer SGC7901 and liver cancer BEL-7402 cells. |
| doi_str_mv | 10.1016/S1875-5364(18)30085-2 |
| format | Article |
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Their cytotoxic activities were tested in two cancer cell lines by MTT method. One of the steroidal glycosides (6) showed significant cytotoxic activity against gastric cancer SGC7901 and liver cancer BEL-7402 cells.</description><identifier>ISSN: 1875-5364</identifier><identifier>EISSN: 1875-5364</identifier><identifier>DOI: 10.1016/S1875-5364(18)30085-2</identifier><identifier>PMID: 30080648</identifier><language>eng</language><publisher>China: Elsevier B.V</publisher><subject>Cytotoxic activity ; Furostanol glycoside ; Solanum lyratum ; Steroidal alkaloid</subject><ispartof>Chinese journal of natural medicines, 2018-07, Vol.16 (7), p.499-504</ispartof><rights>2018 China Pharmaceutical University</rights><rights>Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. 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Their cytotoxic activities were tested in two cancer cell lines by MTT method. One of the steroidal glycosides (6) showed significant cytotoxic activity against gastric cancer SGC7901 and liver cancer BEL-7402 cells.</description><subject>Cytotoxic activity</subject><subject>Furostanol glycoside</subject><subject>Solanum lyratum</subject><subject>Steroidal alkaloid</subject><issn>1875-5364</issn><issn>1875-5364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkM1OxSAQhYnRqFEfQcNSF1UohbYrY4x_idGFukZKB0XpRYGqfXu5XjXuZDMzcM4M8yG0Tck-JVQc3NCm5gVnotqlzR4jpOFFuYTWf6-X_-RraCvGJ5KP4JRRsYrW5g4iqmYd3V_BO44Jgre9cli5Z-VyitWsx2YMPiY18w4_uEn7aHuI2EbvVIL8HPyAb3IxGwfspqBSju82PWI9JZ_8h9U2TZtoxSgXYes7bqC705Pb4_Pi8vrs4vjostBM8FTUnSjrnilRsppXTc1Ia8qWmlyS0piecW4IAGs7JhjQTpVGiE7XpGGMV1SxDbS76PsS_OsIMcnBRg0ufw_8GGVJmqqlbUvLLOULqc77xQBGvgQ7qDBJSuScr_ziK-fwJG3kF1859-18jxi7Afpf1w_NLDhcCCAv-mYhyKgtzDT0NoBOsvf2nxGfmJeK3g</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>XU, Yun-Ling</creator><creator>LV, Jia</creator><creator>WANG, Wei-Fang</creator><creator>LIU, Yue</creator><creator>XU, Ya-Juan</creator><creator>XU, Tun-Hai</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201807</creationdate><title>New steroidal alkaloid and furostanol glycosides isolated from Solanum lyratum with cytotoxicity</title><author>XU, Yun-Ling ; LV, Jia ; WANG, Wei-Fang ; LIU, Yue ; XU, Ya-Juan ; XU, Tun-Hai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-7b627d3a62375487309f291f23702ffd355f0ee39b363e1ba2f66bc70833541a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cytotoxic activity</topic><topic>Furostanol glycoside</topic><topic>Solanum lyratum</topic><topic>Steroidal alkaloid</topic><toplevel>online_resources</toplevel><creatorcontrib>XU, Yun-Ling</creatorcontrib><creatorcontrib>LV, Jia</creatorcontrib><creatorcontrib>WANG, Wei-Fang</creatorcontrib><creatorcontrib>LIU, Yue</creatorcontrib><creatorcontrib>XU, Ya-Juan</creatorcontrib><creatorcontrib>XU, Tun-Hai</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chinese journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>XU, Yun-Ling</au><au>LV, Jia</au><au>WANG, Wei-Fang</au><au>LIU, Yue</au><au>XU, Ya-Juan</au><au>XU, Tun-Hai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New steroidal alkaloid and furostanol glycosides isolated from Solanum lyratum with cytotoxicity</atitle><jtitle>Chinese journal of natural medicines</jtitle><addtitle>Chin J Nat Med</addtitle><date>2018-07</date><risdate>2018</risdate><volume>16</volume><issue>7</issue><spage>499</spage><epage>504</epage><pages>499-504</pages><issn>1875-5364</issn><eissn>1875-5364</eissn><abstract>Two previously undescribed steroidal compounds, 16, 23-epoxy-22, 26-epimino-cholest-22(N), 23, 25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-(25R)-5α-furost-20(22)-en-3β, 26-diol (2), together with 7 known ones including 26-O-β-D-glucopyranosyl-(25R)-5, 20(22)-dien-furost-3β, 26-diol (3), (25R)-5-en-spirost-3β-ol-O-β-D-glucopyranosyl-(1→4)-[α-L-rhmanopyranosyl-(1→2)]-β-D-galactopyranoside (4), funkioside D (5), aspidistrin (6), tigogenin-3-O-β-D-lucotrioside (7), desglucolanatigonin II (8), and degalactotigonin (9), were isolated from Solanum lyratum Thunb. Their cytotoxic activities were tested in two cancer cell lines by MTT method. One of the steroidal glycosides (6) showed significant cytotoxic activity against gastric cancer SGC7901 and liver cancer BEL-7402 cells.</abstract><cop>China</cop><pub>Elsevier B.V</pub><pmid>30080648</pmid><doi>10.1016/S1875-5364(18)30085-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Cytotoxic activity Furostanol glycoside Solanum lyratum Steroidal alkaloid |
| title | New steroidal alkaloid and furostanol glycosides isolated from Solanum lyratum with cytotoxicity |
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